Abstract:
:Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also, it was prominently associated with clinicopathological features. Functional assays showed that RB cell proliferation, invasion and migration can be promoted by miR-494 overexpression. Besides, phosphatase and tensin homolog (PTEN) was verified as a possible target of miR-494 by a luciferase assay, western blot and qRT-PCR assay in RB. miR-494 and PTEN expression was negatively related in a correlation analysis on tumor tissues of 66 patients. In addition, PTEN was proved to reverse miR-494 effect on RB cell progression. Moreover, PI3K/AKT signaling pathway was validated to take part in RB progression. Taken together, the current study proposes that miR-494 might function as a tumor promoter and regulates RB progression through targeting PTEN.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xu F,Liu G,Wang L,Wang X,Jin X,Bo Wdoi
10.3892/ol.2020.11749subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1952-1960issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-11749journal_volume
20pub_type
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