Co-expression and significance of Dok2 and Ras p21 protein activator 1 in breast cancer.

abstract：:Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...

journal_title：Oncology letters

authors： Lin YH,Hu C,Chuang HW,Lin MY

更新日期：2015-07-01 00:00:00

abstract：:Increasing evidence has confirmed that long non-coding RNAs (lncRNAs) serve critical roles in the development of a large number of human malignancies, including glioma. Several previously published studies have reported that the lncRNA retinal non-coding RNA3 (RNCR3; also termed LINC00599) exerts important roles in ce...

journal_title：Oncology letters

authors： Zhu B,Zhang S,Meng N,Zhang H,Yuan S,Zhang J

更新日期：2019-12-01 00:00:00

abstract：:Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...

journal_title：Oncology letters

authors： Kochi T,Shimizu M,Ohno T,Baba A,Sumi T,Kubota M,Shirakami Y,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2014-07-01 00:00:00

abstract：:Primary hepatic lymphoma (PHL) is an uncommon lymphoid tumor with varied clinical features and treatment outcome. In the present study, the case of a 56-year-old patient with PHL and no clinical presentation was reported. During a routine physical examination, multiple hypodense nodules were incidentally detected in r...

journal_title：Oncology letters

authors： Zhang KJ,Chen S,Chen JL,Dong LH

更新日期：2015-04-01 00:00:00

abstract：:Berberine is sourced from multiple medicinal herb resources and is easy to extract. With the advantages of low price, safety and convenience, berberine may have potential for wide clinical use. The present study aimed to investigate whether berberine inhibited the viability of colon cancer and whether it regulated the...

journal_title：Oncology letters

authors： Lü Y,Han B,Yu H,Cui Z,Li Z,Wang J

更新日期：2018-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...

journal_title：Oncology letters

authors： Lai PL,Chen TC,Feng CY,Lin H,Ng CH,Chen Y,Hsiao M,Lu J,Huang HC

更新日期：2020-09-01 00:00:00

abstract：:We investigated whether treatment package time was significantly associated with survival outcomes of resectable locally-advanced laryngeal squamous cell carcinoma in patients who consecutively underwent various treatments, including surgery alone and salvage surgery for residual tumor. A total of 100 patients with cl...

journal_title：Oncology letters

authors： Suzuki H,Terada H,Hanai N,Nishikawa D,Koide Y,Beppu S,Kodaira T,Tachibana H,Koide Y,Tanaka H,Hasegawa Y

更新日期：2019-01-01 00:00:00

abstract：:MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...

journal_title：Oncology letters

authors： Lin MH,Chen YZ,Lee MY,Weng KP,Chang HT,Yu SY,Dong BJ,Kuo FR,Hung LT,Liu LF,Chen WS,Tsai KW

更新日期：2018-06-01 00:00:00

abstract：:A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...

journal_title：Oncology letters

authors： Suciu C,Muresan A,Cornea R,Suciu O,Dema A,Raica M

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...

journal_title：Oncology letters

authors： Chen S,Wang Y,Ruan W,Wang X,Pan C

更新日期：2014-11-01 00:00:00

abstract：:C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was ex...

journal_title：Oncology letters

authors： Yang Y,Hou J,Shao M,Zhang W,Qi Y,E S,Wang S,Sui H,Meng D,Wang B,Wang M,Han Y,Cao Y,Huang X,Li Y,Zhang P,Wang W

更新日期：2017-12-01 00:00:00

abstract：:The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

journal_title：Oncology letters

authors： Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

更新日期：2018-04-01 00:00:00

abstract：:The purpose of the present study was to explore the targets of forkhead box D3 (FOXD3) in lung cancer, and thus contribute to the diagnosis and therapy of the disease. The gene expression profile of GSE64513 was downloaded from the Gene Expression Omnibus database. The dataset contained 3 FOXD3 knockout A549 lung canc...

journal_title：Oncology letters

authors： Jiang W,Liu P,Li X

更新日期：2018-03-01 00:00:00

abstract：:Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyse...

journal_title：Oncology letters

authors： Li CY,Liang GY,Yao WZ,Sui J,Shen X,Zhang YQ,Ma SM,Ye YC,Zhang ZY,Zhang WH,Yin LH,Pu YP

更新日期：2018-06-01 00:00:00

abstract：:The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pa...

journal_title：Oncology letters

authors： Chen Y,Shi D,Dong F,Han SG,Qian ZH,Yang LI,Wang Y,Yu RS,Li QH,Fu YB

更新日期：2015-10-01 00:00:00

abstract：:Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summari...

journal_title：Oncology letters

authors： Höres T,Wendelin K,Schaefer-Eckart K

更新日期：2018-01-01 00:00:00

abstract：:In colorectal cancer (CRC), KRAS and BRAF mutations in primary tumors are associated with resistance to anti-epidermal growth factor receptor (anti-EGFR)-based therapies. However, the correlation between KRAS/BRAF mutation in primary tumors and serum has not been well studied. To evaluate the degree of concordance of ...

journal_title：Oncology letters

authors： Pu X,Pan Z,Huang Y,Tian Y,Guo H,Wu L,He X,Chen X,Zhang S,Lin T

更新日期：2013-01-01 00:00:00

abstract：:Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investi...

journal_title：Oncology letters

authors： Jia Y,Yuan H,Shan S,Xu G,Yu J,Zhao C,Mou X

更新日期：2016-11-01 00:00:00

abstract：:The epithelial cell adhesion molecule (EpCAM) is overexpressed in the majority of human epithelial carcinomas, and its overexpression is associated with proliferation and neoplastic transformation. However, the precise molecular mechanism involved in EpCAM-related proliferation and metastasis in hypopharyngeal carcino...

journal_title：Oncology letters

authors： Mu Y,Sa N,Yu L,Lu S,Wang H,Xu W

更新日期：2014-07-01 00:00:00

abstract：:The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian can...

journal_title：Oncology letters

authors： Selle F,Emile G,Pautier P,Asmane I,Soares DG,Khalil A,Alexandre J,Lhommé C,Ray-Coquard I,Lotz JP,Goldwasser F,Tazi Y,Heudel P,Pujade-Lauraine E,Gouy S,Tredan O,Barbaza MO,Ady-Vago N,Dubot C

更新日期：2016-03-01 00:00:00

abstract：:Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...

journal_title：Oncology letters

authors： Ning D,Jin M,Xv T,Sun J,Li M

更新日期：2018-09-01 00:00:00

abstract：:The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...

journal_title：Oncology letters

authors： Zhou Z,Ware JH,Kennedy AR

更新日期：2011-09-01 00:00:00

abstract：:Human four-and-a-half LIM domains protein 1 (FHL1) is a member of the FHL protein family, which serves an important role in multiple cellular events by interacting with transcription factors using its cysteine-rich zinc finger motifs. A previous study indicated that FHL1 was downregulated in several types of human can...

journal_title：Oncology letters

authors： Li SZ,Hu YY,Zhao JL,Zang J,Fei Z,Han H,Qin HY

更新日期：2020-06-01 00:00:00

abstract：:Ovarian cancer is the most fatal gynecological cancer, with a 5-year survival rate of only 30%. Lysophosphatidic acid (LPA), which possesses growth factor-like functions, is a major regulatory factor in the peritoneal metastasis of ovarian cancer. LPA stimulates the expression of numerous genes that are associated wit...

journal_title：Oncology letters

authors： Wang H,Liu W,Wei D,Hu K,Wu X,Yao Y

更新日期：2014-05-01 00:00:00

abstract：:The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC ...

journal_title：Oncology letters

authors： Aoun F,Kourie HR,El Rassy E,van Velthoven R

更新日期：2016-09-01 00:00:00

abstract：:Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...

journal_title：Oncology letters

authors： Qin J,Li Q,Zeng Z,Wu P,Jiang Y,Luo T,Ji X,Zhang Q,Hao Y,Chen L

更新日期：2018-06-01 00:00:00

abstract：:Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC), but radioresistance often remains an obstacle to successful treatment. In our previous study, it was demonstrated that Annexin A1 (ANXA1) was involved in the p53-mediated radioresponse in NPC cells, which suggested that it may be associated with...

journal_title：Oncology letters

authors： Huang L,Liao L,Wan Y,Cheng A,Li M,Chen S,Li M,Tan X,Zeng G

更新日期：2016-12-01 00:00:00

abstract：:The long non-coding RNA (lncRNA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular ...

journal_title：Oncology letters

authors： Zhang L,Li Y,Sona L

更新日期：2020-01-01 00:00:00

abstract：:The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...

journal_title：Oncology letters

authors： A Y,Li Y,Zhao S

更新日期：2018-02-01 00:00:00

abstract：:Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...

journal_title：Oncology letters

authors： Liu YZ,Wang TT,Zhang YZ

更新日期：2016-02-01 00:00:00