Gemcitabine resistance in triple-negative breast cancer cells can be reverted by Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.

abstract：:Pancreatic cancer is one of the most lethal cancers. Transmembrane 4 superfamily member 5 protein (TM4SF5) is one of the candidate molecular targets used for the prevention and treatment of TM4SF5-expressing cancers, including hepatocellular carcinoma, colon cancer and pancreatic cancer. Recently, a previous study rep...

journal_title：Oncology letters

authors： Park S,Kim D,Park JA,Kwon HJ,Lee Y

更新日期：2020-01-01 00:00:00

abstract：:The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...

journal_title：Oncology letters

authors： Xiang L,Dong W,Wang R,Wei J,Qiu G,Cen J,Chen Z,Zheng X,Hu S,Xie X,Cao X,Gu W

更新日期：2014-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...

journal_title：Oncology letters

authors： Hu Z,Xie F,Hu A,Xu M,Liu Y,Zhang J,Xiao J,Song Y,Zhong J,Chen B

更新日期：2020-11-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Wang P,Zhao JG,Wang ZF,Chen LI

更新日期：2016-05-01 00:00:00

abstract：:Radiotherapy is the primary treatment for nasopharyngeal carcinoma (NPC), but radioresistance often remains an obstacle to successful treatment. In our previous study, it was demonstrated that Annexin A1 (ANXA1) was involved in the p53-mediated radioresponse in NPC cells, which suggested that it may be associated with...

journal_title：Oncology letters

authors： Huang L,Liao L,Wan Y,Cheng A,Li M,Chen S,Li M,Tan X,Zeng G

更新日期：2016-12-01 00:00:00

abstract：:Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...

journal_title：Oncology letters

authors： Ma J,Liang L,Liu H

更新日期：2012-09-01 00:00:00

abstract：:Severe hemorrhage following a prostatectomy is a rare and serious complication. A 63-year-old male with severe hemorrhage following radical prostatectomy which led to hypovolemic shock presented at our department and was treated with superselective internal iliac arterial embolization. At 6 months follow-up, the patie...

journal_title：Oncology letters

authors： Cheng S,Xu L,Li G,Chen Y,Hu H,Zhang Z,Ding G

更新日期：2012-09-01 00:00:00

abstract：:Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...

journal_title：Oncology letters

authors： Khamwut A,Jevapatarakul D,Reamtong O,T-Thienprasert NP

更新日期：2019-09-01 00:00:00

abstract：:Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...

journal_title：Oncology letters

authors： Schcolnik-Cabrera A,Dominguez-Gómez G,Chávez-Blanco A,Ramírez-Yautentzi M,Morales-Bárcenas R,Chávez-Díaz J,Taja-Chayeb L,Dueáas-González A

更新日期：2019-12-01 00:00:00

abstract：:This study was designed to explore the expression of phosphoinositide-dependent protein kinase 1 (PDK-1), deleted in malignant brain tumors (DMBT1) in the thyroid carcinoma. A total of 87 fresh samples of thyroid carcinoma from surgical resection in The Second People's Hospital of Lianyungang from June 2016 to March 2...

journal_title：Oncology letters

authors： Sun Z,Xu L

更新日期：2019-09-01 00:00:00

abstract：:AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...

journal_title：Oncology letters

authors： Zhou R,Wu J,Tang X,Wei X,Ju C,Zhang F,Sun J,Shuai D,Zhang Z,Liu Q,Lv XB

更新日期：2018-08-01 00:00:00

abstract：:Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologi...

journal_title：Oncology letters

authors： Antohe M,Nedelcu RI,Nichita L,Popp CG,Cioplea M,Brinzea A,Hodorogea A,Calinescu A,Balaban M,Ion DA,Diaconu C,Bleotu C,Pirici D,Zurac SA,Turcu G

更新日期：2019-05-01 00:00:00

abstract：:Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B-cell primary non-Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7-year period of complete ...

journal_title：Oncology letters

authors： Hu JY,Yu D,Wu YH

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitor...

journal_title：Oncology letters

authors： Zhong L,Chen J,Huang X,Li Y,Jiang T

更新日期：2018-08-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...

journal_title：Oncology letters

authors： Zhang Y,Guan X,Wang H,Wang Y,Yue D,Chen R

更新日期：2020-10-01 00:00:00

abstract：:Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Yin Y,Hu X,Cui Y

更新日期：2018-01-01 00:00:00

abstract：:Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Pre...

journal_title：Oncology letters

authors： Ju X,Huang P,Chen M,Wang Q

更新日期：2017-12-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell ...

journal_title：Oncology letters

authors： Kita H,Okamoto K,Kushima R,Kawauchi A,Chano T

更新日期：2015-08-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to s...

journal_title：Oncology letters

authors： Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjacent tissues from pa...

journal_title：Oncology letters

authors： Ling B,Yao M,Li G,Liu J,Liu B,Wang W,Jiang B

更新日期：2020-08-01 00:00:00

abstract：:Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...

journal_title：Oncology letters

authors： Shen A,Ma J,Hu X,Cui X

更新日期：2020-06-01 00:00:00

abstract：:The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV...

journal_title：Oncology letters

authors： Loizou C,Laurell G,Lindquist D,Öfverman C,Stefansson K,Nylander K,Olofsson K

更新日期：2015-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains the third leading cause of cancer-associated mortality. The present study aimed to fully elucidate the pathogenesis of CRC and identify associated genes in tumor development. Microarray GSE44076, GSE41328 and GSE44861 datasets were...

journal_title：Oncology letters

authors： Shen X,Yue M,Meng F,Zhu J,Zhu X,Jiang Y

更新日期：2016-11-01 00:00:00

abstract：:Esophageal cancer is one of the most prevalent forms of cancer and has a particularly high mortality rate due to early metastasis; however, the underlying mechanisms of its formation and progression remain unclear. The present study performed immunohistochemical analysis and observed that the expression of activating ...

journal_title：Oncology letters

authors： Li J,Yang Z,Chen Z,Bao Y,Zhang H,Fang X,Yang W

更新日期：2016-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the cytotoxic effect of thalidomide on 4T1 and 4THMpc mouse breast cancer cell lines. Mouse breast cancer cells (4T1) and cells derived from metastatic lesions (4THMpc) were treated with various doses of thalidomide [10(-2)-100 µM dissolved in dimethyl sulfoxide (DMSO) as reco...

journal_title：Oncology letters

authors： Oz ES,Aydemir E,Fışkın K

更新日期：2012-04-01 00:00:00

abstract：:Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...

journal_title：Oncology letters

authors： Yang L,Huang M,Tan J,Hou J,He J,Wang F,Cui H,Yi L

更新日期：2017-06-01 00:00:00

abstract：:KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...

journal_title：Oncology letters

authors： Lee HS,Hwang DY,Han HS

更新日期：2020-07-01 00:00:00

abstract：:Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...

journal_title：Oncology letters

authors： Cinque L,Sparaneo A,Cetani F,Coco M,Clemente C,Chetta M,Balsamo T,Battista C,Sanpaolo E,Pardi E,D'Agruma L,Marcocci C,Maiello E,Hendy GN,Cole DEC,Scillitani A,Guarnieri V

更新日期：2017-07-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00