Abstract:
:Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologic response. Melanoma has been historically considered an immunogenic malignancy. It often contains great amount of immune cells (different subsets of T-cells, dendritic cells, macrophages, neutrophils, mast cells, B lymphocytes), which may reflect a continuous intercommunication between host and tumor. It is not established if tumor-infiltrating lymphocytes (TILs) are induced by tumor cells or by other components of the microenvironment or when they are a host direct immunologic reaction. It has been observed that in many cases, the presence of a dense TIL is associated with good prognosis. The pattern and activation state of the cells which constitute TIL is variable and modulates the clinical outcome. An important step in the understanding of tumor immunobiology is the analysis of the populations and subsets of immune cells that form TIL. Besides its prognostic significance, after approval of cytotoxic T lymphocyte antigen 4, programmed cell death-1 and programmed death-1 ligand antibodies for the treatment of melanoma, the assessment of immune infiltrate composition has become even more captivating, as it could provide new target molecules and new biomarkers for predicting the effect of the treatment and disease outcome in patients treated with immunotherapy. In this review we discuss current state of knowledge in the field of immune cells that infiltrate melanoma, resuming the potential of TIL components to become prognostic markers for natural evolution, for response to drugs or valuable targets for new medication.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Antohe M,Nedelcu RI,Nichita L,Popp CG,Cioplea M,Brinzea A,Hodorogea A,Calinescu A,Balaban M,Ion DA,Diaconu C,Bleotu C,Pirici D,Zurac SA,Turcu Gdoi
10.3892/ol.2019.9940subject
Has Abstractpub_date
2019-05-01 00:00:00pages
4155-4161issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-9940journal_volume
17pub_type
杂志文章,评审相关文献
Oncology Letters文献大全abstract::Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8369
更新日期:2018-06-01 00:00:00
abstract::The Na+/K+-ATPase α subunit is highly expressed in malignant cells. Ouabain, a cardioactive glycoside, binds to the Na+/K+-ATPase α subunit and inhibits the activity of Na+/K+-ATPase. In the present study, the effect of ouabain on the migration of A549 cells was analyzed using the wound healing and transwell chamber m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1406
更新日期:2013-08-01 00:00:00
abstract::Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5185
更新日期:2016-11-01 00:00:00
abstract::The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4176
更新日期:2016-03-01 00:00:00
abstract::Gemcitabine (GCB), which functions via the inhibition of DNA synthesis, is commonly used in the treatment of bladder cancer; however, its response rate is not satisfactory due to the development of drug resistance. The potential for phytochemicals to reverse drug resistance in bladder cancer tumor cells was evaluated....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11023
更新日期:2019-12-01 00:00:00
abstract::We investigated the possible association between DLKI gene promoter region methylation and the increased invasion capacity of non-small cell lung cancer (NSCLC). Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells....
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2017.6019
更新日期:2017-06-01 00:00:00
abstract::Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully under...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12235
更新日期:2020-12-01 00:00:00
abstract::The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The pote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6042
更新日期:2017-06-01 00:00:00
abstract::The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2626
更新日期:2015-01-01 00:00:00
abstract::The present study aimed to retrospectively review the contribution of 18F-fluorodeoxygluose-positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of biochemical recurrence in patients with a diagnosis of local-stage prostate cancer (PCa) who underwent radical prostatectomy (RP) or receive...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3903
更新日期:2016-01-01 00:00:00
abstract::The present study evaluated androgen deprivation methods to determine the approach that most improves the progression-free survival (PFS) of patients with metastatic prostate cancer. Patients had received continuous maximal androgen blockade (MAB) or monotherapy [luteinizing-hormone releasing hormone (LHRH) agonist or...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6056
更新日期:2017-06-01 00:00:00
abstract::Patients with longstanding ulcerative colitis have an increased risk of colorectal cancer. Mouse models for colitis-associated tumors are indispensable for the development of novel strategies for prevention and intervention, as well as an improved understanding of the mechanisms underlying tumor formation. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6645
更新日期:2017-09-01 00:00:00
abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2738
更新日期:2015-02-01 00:00:00
abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.522
更新日期:2012-03-01 00:00:00
abstract::The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10293
更新日期:2019-07-01 00:00:00
abstract::Discovering the underlying signalling pathways that control cancer cells is crucial for understanding their biology and to develop therapeutic regimens. Thus, the aim of the present study was to determine the effect of Cripto-1 on pathways controlling glioblastoma (GBM) cell function. To this end, changes in protein p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10626
更新日期:2019-09-01 00:00:00
abstract::Anesthetic effect of propofol combined with remifentanil or sevoflurane intravenous anesthesia on patients undergoing radical gastrectomy was evaluated. The clinical data of 516 cancer patients who received radical gastrectomy in the First Bethune Hospital of Jilin University between January 2011 and December 2017 wer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10238
更新日期:2019-06-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00
abstract::Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6178
更新日期:2017-07-01 00:00:00
abstract::As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7432
更新日期:2018-01-01 00:00:00
abstract::The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6692
更新日期:2017-10-01 00:00:00
abstract::The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1348
更新日期:2013-07-01 00:00:00
abstract::Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2488
更新日期:2014-11-01 00:00:00
abstract::There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (U...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4945
更新日期:2016-10-01 00:00:00
abstract::Increasing number of microRNAs (miRNAs) have been reported to play an important role in the development and progression of non-small cell lung cancer (NSCLC). In particular, microRNA-497-5p (miR-497-5p) has been proposed as a tumor suppressor miRNA in human cancers. However, the role of miR-497-5p and its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9954
更新日期:2019-03-01 00:00:00
abstract::TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8262
更新日期:2018-05-01 00:00:00
abstract::LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10473
更新日期:2019-08-01 00:00:00
abstract::Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6898
更新日期:2017-11-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2135
更新日期:2014-07-01 00:00:00
abstract::In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1660
更新日期:2014-01-01 00:00:00