Abstract:
:There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (Union for International Cancer Control stage I or IV) by immunohistochemistry. MAGE-A1, -A6, -A8, -A9 and -A11 were expressed at significantly higher levels at the tumor front of stage IV specimens compared with the tumor front of stage I specimens. In stage I cancer, the tumor center and front ratio (C/F ratio) for each subgroup was >1.0. In stage IV cancer, the C/F ratio was <1.0 in 9/11 subgroups. The most significant change in the expression pattern was observed for MAGE-A11. These results indicated that there is a marked alteration and shift to the invasive front of almost all MAGE-A subgroups, but particularly MAGE-A11, during the progression of head and neck squamous cell carcinoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Hartmann S,Brisam M,Rauthe S,Driemel O,Brands RC,Rosenwald A,Kübler AC,Müller-Richter UDdoi
10.3892/ol.2016.4945subject
Has Abstractpub_date
2016-10-01 00:00:00pages
2942-2947issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-4945journal_volume
12pub_type
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