MicroRNA-497-5p inhibits proliferation and invasion of non-small cell lung cancer by regulating FGF2.

abstract：:Ilex kudingcha C.J. Tseng (Kudingcha) is a traditional Chinese drink consumed in East Asia. The present study evaluated the in vitro anticancer effects of Kudingcha in MCF-7 human breast adenocarcinoma cells using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay. At a concentration of 200 μg/...

journal_title：Oncology letters

authors： Zhao X,Wang Q,Qian Y,Song JL

更新日期：2013-05-01 00:00:00

abstract：:A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...

journal_title：Oncology letters

authors： Nickelsen MN,VON Holstein S,Hansen AB,Prause JU,Heegaard S

更新日期：2015-08-01 00:00:00

abstract：:Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...

journal_title：Oncology letters

authors： Nishihara K,Suekane S,Ueda K,Nakiri M,Matsuo M,Igawa T

更新日期：2019-06-01 00:00:00

abstract：:Although hepatocellular carcinoma (HCC) is associated with poor prognosis worldwide, the molecular mechanisms underlying the carcinogenesis and progression of this disease remain unclear. Several tumor characteristics have previously been demonstrated to be prognostic factors of survival following hepatic resection, o...

journal_title：Oncology letters

authors： Inokawa Y,Inaoka K,Sonohara F,Hayashi M,Kanda M,Nomoto S

更新日期：2016-11-01 00:00:00

abstract：:A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...

journal_title：Oncology letters

authors： Kim DD,Yang CS,Chae HD,Kwak SG,Jeon CH

更新日期：2017-07-01 00:00:00

abstract：:Targeted therapy of non-small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated with improved prognosis. However, there is a shortage on data from real-world clinical practice in management of EGFR-positive NSCLC patients in Poland. The present stu...

journal_title：Oncology letters

authors： Ramlau R,Krawczyk P,Dziadziuszko R,Chmielewska I,Milanowski J,Olszewski W,Stencel K,Ramlau-Piątek K,Segiet A,Skroński M,Grudny J,Chorostowska-Wynimko J

更新日期：2017-11-01 00:00:00

abstract：:Gastric cancer is a common malignancy in China, with the second highest mortality rate worldwide. Advanced gastric cancer usually exhibits a poor prognosis with a low 5-year survival rate. Therefore, developing novel drugs for the treatment of this cancer will be beneficial for patients. Demethylzeylasteral, an extrac...

journal_title：Oncology letters

authors： Yang Y,Zhao M,Hu T,Su F,Qian F,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2017.5668.]. ...

journal_title：Oncology letters

authors： Lee J,Kim DS,Lee HS,Choi SI,Cho YG

更新日期：2017-11-01 00:00:00

abstract：:Increasing evidence has confirmed that long non-coding RNAs (lncRNAs) serve critical roles in the development of a large number of human malignancies, including glioma. Several previously published studies have reported that the lncRNA retinal non-coding RNA3 (RNCR3; also termed LINC00599) exerts important roles in ce...

journal_title：Oncology letters

authors： Zhu B,Zhang S,Meng N,Zhang H,Yuan S,Zhang J

更新日期：2019-12-01 00:00:00

abstract：:Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...

journal_title：Oncology letters

authors： Liu J,Mi B,Wang Y,Shi C,Mi X,Lu Y,Yu P

更新日期：2018-06-01 00:00:00

abstract：:Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is currently approved in Japan for treatment of breast cancer. However, apart from phase I clinical trials, data regarding Japanese patients are scant. In the present study, the efficacy and safety of nab-paclitaxel therapy were retrospectively analyzed in 22 pati...

journal_title：Oncology letters

authors： Takashima S,Kiyoto S,Takahashi M,Hara F,Aogi K,Ohsumi S,Mukai R,Fujita Y

更新日期：2015-04-01 00:00:00

abstract：:The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...

journal_title：Oncology letters

authors： Wang G,Cheng B,Jia R,Tan B,Liu W

更新日期：2021-01-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy affecting pediatric and adult populations. Although the outcomes of ALL in children have improved markedly in previous years, limited treatment strategies are available at present for adult patients with ALL. Wee1 is a crucial cell cycle checkp...

journal_title：Oncology letters

authors： Duan Y,Dong X,Nie J,Li P,Lu F,Ma D,Ji C

更新日期：2018-10-01 00:00:00

abstract：:Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...

journal_title：Oncology letters

authors： Huang J,Peng X,Zhang K,Li C,Su B,Zhang Y,Yu W

更新日期：2017-11-01 00:00:00

abstract：:The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...

journal_title：Oncology letters

authors： Chen L,Liu Y,Wang W,Liu K

更新日期：2015-07-01 00:00:00

abstract：:Congenital leukemia is rare disease with an incidence of one to five cases per million births. Transient abnormal myelopoiesis (TAM), also called transient myeloproliferative disorder, is a pre-leukemia disorder that may occur in Down syndrome (DS) or non-DS infants. TAM may enter spontaneous remission; however, conti...

journal_title：Oncology letters

authors： Salvatori G,Foligno S,Sirleto P,Genovese S,Russo S,Coletti V,Dotta A,Luciani M

更新日期：2017-01-01 00:00:00

abstract：:The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...

journal_title：Oncology letters

authors： Rivas M,Rojas E,Araya MC,Calaf GM

更新日期：2015-10-01 00:00:00

abstract：:The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...

journal_title：Oncology letters

authors： Zhao Y,Jiang H,Gu M,Zu C,Zheng X

更新日期：2020-11-01 00:00:00

abstract：:Propofol is an intravenous anesthetic, which is widely used in clinical anesthesia induction and maintenance and is critical in the sedation of patients. However, the functions and mechanisms of propofol on apoptosis of melanoma cells remain unclear. The present study investigated whether propofol promotes cell apopto...

journal_title：Oncology letters

authors： Shang Z,Feng H,Cui L,Wang W,Fu H

更新日期：2018-01-01 00:00:00

abstract：:Fatty acid-binding protein 5 (FABP5), which participates in mediating the biological properties of tumor cells, has been recognized in several neoplasms. The present study aims to investigate FABP5 transcriptional expression profiles, reveal its underlying biological interaction networks and define its prognostic valu...

journal_title：Oncology letters

authors： Xu Y,Xu WH,Yang XL,Zhang HL,Zhang XF

更新日期：2020-03-01 00:00:00

abstract：:Dendrobium candidum Wall ex Lindl. (D. candidum) is a traditional Chinese medicine widely used in Asia. The present study has showed that D. candidum exerted an anti-metastatic effect in mice injected with 26-M3.1 colon carcinoma cells. D. candidum showed the most marked tumor inhibitory rate of 64.5% at a dose of 400...

journal_title：Oncology letters

authors： Li G,Sun P,Zhou Y,Zhao X,Chen F

更新日期：2014-10-01 00:00:00

abstract：:The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...

journal_title：Oncology letters

authors： Tane S,Nishio W,Ogawa H,Hokka D,Tane K,Tanaka Y,Tauchi S,Uchino K,Sakai Y,Ohbayashi C,Yoshimura M,Maniwa Y

更新日期：2014-09-01 00:00:00

abstract：:Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...

journal_title：Oncology letters

authors： Lu K,Shen H,Zhu S,Bi S,Wu S

更新日期：2018-08-01 00:00:00

abstract：:Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative com...

journal_title：Oncology letters

authors： Yoon KB,Cho SY,An SJ,Park KR,Lee HJ,Yoon HS,Lee SM,Kim YC,Han SY

更新日期：2017-08-01 00:00:00

abstract：:The RAS/RAF and PI3K/PTEN signaling pathways play central roles in hepatocarcinogenesis. KRAS, NRAS, HRAS, BRAF, PIK3CA, PIK3R1 and PTEN are key cancer-related genes in the RAS/RAF and PI3K/PTEN signaling pathways. Genetic alterations in these genes often lead to the dysregulation of the two cascades. Little is known ...

journal_title：Oncology letters

authors： Hou W,Liu J,Chen P,Wang H,Ye BC,Qiang F

更新日期：2014-09-01 00:00:00

abstract：:It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the hu...

journal_title：Oncology letters

authors： Cheng L,Kong B,Zhao Y,Jiang J

更新日期：2018-03-01 00:00:00

abstract：:The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...

journal_title：Oncology letters

authors： Zhang Z,Zou J,Li Y,Liu Z,Xu R,Tian W,Zhao Z,Sun H,Han J,Wang J,Zhang B,Ju Y

更新日期：2015-05-01 00:00:00

abstract：:Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investig...

journal_title：Oncology letters

authors： Li Y,Huang N,Wang C,Ma H,Zhou M,Lin L,Huang Z,Sun L,Shi M,Liao W

更新日期：2018-09-01 00:00:00

abstract：:Cervical carcinoma expressed PCNA regulatory long non-coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regul...

journal_title：Oncology letters

authors： Wang X,Zhou L,Zhang H,Ou H,Long W,Liu X

更新日期：2020-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...

journal_title：Oncology letters

authors： Li BS,Huang JY,Guan J,Chen LH

更新日期：2018-07-01 00:00:00