Abstract:
:Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investigated, and the results revealed that CRA significantly inhibited the viability of MG-63 cells in a dose- and time-dependent manner. A typical apoptotic hallmark such as DNA ladder was detected by agarose gel electrophoresis following treatment with CRA. Further experiments demonstrated that CRA induced apoptosis of MG-63 cells by flow cytometry using propidium iodide and annexin V staining. In addition, it was observed that the apoptosis of MG-63 cells induced by CRA was closely associated with activation of caspase-3 and caspase-9, loss of mitochondrial membrane potential, and release of cytochrome c from mitochondria, suggesting that CRA may trigger the activation of the mitochondria-mediated apoptosis pathway. In addition, the inhibition of caspase activity attenuated the CRA-induced apoptosis of MG-63 cells, which further confirmed the role of the mitochondrial pathway in CRA-induced apoptosis. These results indicated that CRA could induce the apoptosis of osteosarcoma cells through activating the mitochondrial pathway, which provides an evidence that CRA may be a useful chemotherapeutic agent for osteosarcoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jia Y,Yuan H,Shan S,Xu G,Yu J,Zhao C,Mou Xdoi
10.3892/ol.2016.5185subject
Has Abstractpub_date
2016-11-01 00:00:00pages
4187-4194issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-5185journal_volume
12pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Inhibition of nuclear factor-κB (NF-κB) results in antitumor activity in leukemia cells, and may be a potential therapeutic strategy for the treatment of leukemia. However, a significant limitation of NF-κB inhibition in the treatment of leukemia is the low efficiency of this technique. NF-κB inhibitor treatment induc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3786
更新日期:2015-12-01 00:00:00
abstract::The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2256
更新日期:2014-09-01 00:00:00
abstract::Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6195
更新日期:2017-07-01 00:00:00
abstract::In patients with diffuse large B-cell lymphoma (DLBCL) classified as high-intermediate risk or high risk using the International Prognosis Index, the efficacy of high-dose chemotherapy combined with upfront autologous stem cell transplantation (HDT/ASCT) remains controversial in the rituximab era. In the present study...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6589
更新日期:2017-09-01 00:00:00
abstract::Certain internal malignancies, including colon cancer, can develop endobronchial metastasis. The present study reports a case of colon cancer with superficial-type endobronchial metastases in a 76-year-old male. Chest computed tomography revealed small masses and infiltrates in each lung, with bilateral hilar lymph no...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2473
更新日期:2014-11-01 00:00:00
abstract::In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.641
更新日期:2012-06-01 00:00:00
abstract::With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10113
更新日期:2019-05-01 00:00:00
abstract::The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000014
更新日期:2010-01-01 00:00:00
abstract::Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6329
更新日期:2017-08-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been reported to participate in multiple biological processes, including tumorigenesis. In the current study, the function of a novel lncRNA LINC00887 was investigated in lung carcinoma. For this purpose, LINC00887 expression was assessed by reverse-transcription quantitative PCR. C...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12348
更新日期:2021-02-01 00:00:00
abstract::The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7940
更新日期:2018-04-01 00:00:00
abstract::Autophagy is a lysosomal degradation process which is key for the regulation of the turnover of long-lived or damaged proteins and organelles and which promotes cell survival during nutrient deprivation or other microenvironmental stresses. Current evidence supports the hypothesis that autophagy suppresses tumorigenes...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1015
更新日期:2013-02-01 00:00:00
abstract::The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant che...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1792
更新日期:2014-03-01 00:00:00
abstract::Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10958
更新日期:2019-12-01 00:00:00
abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.522
更新日期:2012-03-01 00:00:00
abstract::The present study aimed to identify the level of programmed death-1 (PD-1) expression in infiltrating cluster of differentiation (CD)4+ and CD8+ T cells isolated from lung cancer tissues, and investigated whether the level of PD-1 expression may be directly regulated by lung cancer cells via prostaglandin E2 (PGE2)-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7279
更新日期:2018-01-01 00:00:00
abstract::Effects of miR-135a-5p and miR-141 on the biological function of colorectal cancer SW620 cells were investigated. Fifty-four specimens of cancer tissues and 54 specimens of corresponding adjacent tissues in colon cancer patients who were treated in The Central Hospital of Wuhan from March 2014 to March 2015 were colle...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11598
更新日期:2020-07-01 00:00:00
abstract::Retroperitoneal tumors are lesions with diverse pathological subtypes that originate from the retroperitoneal space; ~40% of these tumors are benign. Due to such lesions often surrounding and associating with vital abdominal blood vessels, a complete surgical resection is difficult. The current study presents a novel ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4395
更新日期:2016-05-01 00:00:00
abstract::The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9897
更新日期:2019-03-01 00:00:00
abstract::The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1608
更新日期:2013-12-01 00:00:00
abstract::Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12275
更新日期:2021-01-01 00:00:00
abstract::The present study aimed to investigate the impact of overexpression of long noncoding RNA PEG10 (lncRNA PEG10) on the proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma (HSCC). Quantitative reverse transcription polymerase chain reaction was used to quantify lncRNA PEG10 expression levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6498
更新日期:2017-09-01 00:00:00
abstract::Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8207
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2521
更新日期:2014-11-01 00:00:00
abstract::Endotracheal intubation (ETI) and laryngeal mask airway (LMA) in terms of hemodynamics and reaction were compared. A total of 54 general anesthesia patients were randomized into two groups with 27 cases in each group. Acceleration index (ACI), cardiac index (CI), cardiac output (CO), left cardiac work (LCW), systemic ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9813
更新日期:2019-02-01 00:00:00
abstract::Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3676
更新日期:2015-11-01 00:00:00
abstract::The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9788
更新日期:2019-02-01 00:00:00
abstract::Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5552
更新日期:2017-03-01 00:00:00
abstract::KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.709
更新日期:2012-08-01 00:00:00
abstract::The causes of lung cancer in never-smokers remain unclear. The potential contribution of human papillomavirus (HPV) to the carcinogenesis of non-small cell lung cancer (NSCLC) has been reported. In 2008, a prospective registry of never-smokers with NSCLC was established at the Kinki-Chuo Chest Medical Center, Sakai, O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2713
更新日期:2015-02-01 00:00:00