Conversion to monotherapy with luteinizing-hormone releasing hormone agonist or orchiectomy after reaching PSA nadir following maximal androgen blockade is able to prolong progression-free survival in patients with metastatic prostate cancer: A propensity

abstract：:Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...

journal_title：Oncology letters

authors： Jia K,Wu Y,Huang J,Chen J,Wei H,Wu H

更新日期：2020-08-01 00:00:00

abstract：:Breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (NPC) following curative treatment. The present study reported two patients with breast metastasis from NPC and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagn...

journal_title：Oncology letters

authors： Xiao W,He Z,Xing C,Zhen W,Wang S,Lin H

更新日期：2015-12-01 00:00:00

abstract：:Xeroderma pigmentosum group C (XPC) is a DNA-damage-recognition gene active at the early stage of DNA repair. XPC also participates in regulation of cell-cycle checkpoint and DNA-damage-induced apoptosis. In the present study, the expression levels of genes involved in nucleotide excision repair (NER) were assessed in...

journal_title：Oncology letters

authors： Zhang Y,Cao J,Meng Y,Qu C,Shen F,Xu L

更新日期：2018-05-01 00:00:00

abstract：:Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...

journal_title：Oncology letters

authors： Liu J,Mi B,Wang Y,Shi C,Mi X,Lu Y,Yu P

更新日期：2018-06-01 00:00:00

abstract：:Cancer cachexia is a syndrome that impairs the quality of life and overall survival of patients, and thus the effectiveness of anticancer agents. There are no effective therapies for cancer cachexia due to the complexity of the syndrome, and insufficient knowledge of its pathogenesis results in difficulty establishing...

journal_title：Oncology letters

authors： Morimoto M,Aikawa K,Hara T,Yamaoka M

更新日期：2017-12-01 00:00:00

abstract：:The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affi...

journal_title：Oncology letters

authors： Göstring L,Lindegren S,Gedda L

更新日期：2016-10-01 00:00:00

abstract：:Cell migration potency is essential in cancer metastasis and is often regulated by extracellular stimuli. Oral squamous cell carcinoma cell lines include those that are sensitive, as well as resistant, to the effects of the epidermal growth factor receptor (EGFR) inhibitor cetuximab on cell migration. In the present s...

journal_title：Oncology letters

authors： Ohnishi Y,Yasui H,Kakudo K,Nozaki M

更新日期：2017-02-01 00:00:00

abstract：:The present study aimed to examine whether serum microRNA (miR)-22 may be considered a potential biomarker to differentiate patients with papillary thyroid cancer (PTC) from healthy controls. Reverse transcription-quantitative polymerase chain reaction demonstrated that serum miR-22 expression was significantly enhanc...

journal_title：Oncology letters

authors： Wang D,Guo C,Kong T,Mi G,Li J,Sun Y

更新日期：2019-03-01 00:00:00

abstract：:The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...

journal_title：Oncology letters

authors： Nakashoji A,Matsui A,Nagayama A,Iwata Y,Sasahara M,Murata Y

更新日期：2017-10-01 00:00:00

abstract：:2',4'-dihydroxy-6'-methoxychalcone (cardamonin) is a natural compound with anti-proliferative effects on several cancer types including nasopharyngeal carcinoma. The effects of cardamonin on melanoma cells are unknown. The present study investigated the anti-proliferative effect of cardamonin on human melanoma cell li...

journal_title：Oncology letters

authors： Yue Y,Liu L,Liu P,Li Y,Lu H,Li Y,Zhang G,Duan X

更新日期：2020-02-01 00:00:00

abstract：:Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentra...

journal_title：Oncology letters

authors： Wang Q,Wei J,Wang C,Zhang T,Huang D,Wei F,He F,Cai W,Yang P,Zeng S,Li W,Cao J

更新日期：2018-08-01 00:00:00

abstract：:Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, a...

journal_title：Oncology letters

authors： Karashima T,Udaka K,Niimura M,Suzuki K,Osakabe H,Shimamoto T,Fukata S,Inoue K,Kuroda N,Seiki M,Shuin T

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...

journal_title：Oncology letters

authors： Yan W,Chen S,Zhao Y,Ye X

更新日期：2018-06-01 00:00:00

abstract：:The Na+/K+-ATPase α subunit is highly expressed in malignant cells. Ouabain, a cardioactive glycoside, binds to the Na+/K+-ATPase α subunit and inhibits the activity of Na+/K+-ATPase. In the present study, the effect of ouabain on the migration of A549 cells was analyzed using the wound healing and transwell chamber m...

journal_title：Oncology letters

authors： Liu N,Li Y,Su S,Wang N,Wang H,Li J

更新日期：2013-08-01 00:00:00

abstract：:microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

journal_title：Oncology letters

authors： Li L,Jia L,Ding Y

更新日期：2018-09-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are the most frequent entity of solid parotid tumors. Nonetheless, their genetics is not yet well understood. Thus, the current study characterized 14 PAs using a unique combination of cytogenetic, molecular cytogenetic and/or molecular karyotyping based approaches. The cu...

journal_title：Oncology letters

authors： Thielker J,Weise A,Othman MAK,Carreria IM,Melo JB,Von Eggeling F,Guntinas-Lichius O,Ziegler M,Liehr T

更新日期：2020-02-01 00:00:00

abstract：:Glucose Transporter 1 (GLUT1) belongs to the expanding mammalian facilitative glucose transporter family. Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. Whereas malignant cells have an accelerated metabolism with inc...

journal_title：Oncology letters

authors： Reis H,Tschirdewahn S,Szarvas T,Rübben H,Schmid KW,Grabellus F

更新日期：2011-11-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:The characteristics of the proliferation of B-cell activating factor (BAFF) and the proliferation-inducing ligand (APRIL) mRNA expression in mononuclear cell in multiple myeloma patients were detected, and the correlation was analyzed between the BAFF and APRIL concentrations in plasma and tumor burden parameters of m...

journal_title：Oncology letters

authors： Pan J,Sun Y,Zhang N,Li J,Ta F,Wei W,Yu S,Ai L

更新日期：2017-09-01 00:00:00

abstract：:The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...

journal_title：Oncology letters

authors： Peng J,Liu R,Peng L,Jia H

更新日期：2018-09-01 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication characterized by intimal proliferation in pulmonary small arteries and arterioles with or without tumor emboli. In the majority of cases, the causative lesion is gastric poorly differentiated adenocarcinoma. In the present stu...

journal_title：Oncology letters

authors： Hotta M,Ishida M,Kojima F,Iwai Y,Okabe H

更新日期：2011-05-01 00:00:00

abstract：:With the continuous advancement of clinical diagnostic techniques, including imaging technology, the incidence of confirmed multiple primary cancers or double primary carcinoma increases yearly. However, studies reporting synchronization surgery performed for primary dual esophageal gastric cancer are rare. The presen...

journal_title：Oncology letters

authors： Zhang XT,Wang W,Zhu Q,Cao M,Jiang ZM,Zang QI

更新日期：2015-08-01 00:00:00

abstract：:Emerging evidence has revealed that mitochondrial DNA (mtDNA) is encapsulated in plasma extracellular vesicles (EVs). However, the characteristics of mtDNA in EVs from patients with cancer remain largely unexplored, which greatly limits its clinical application. Whole genome and capture-based sequencing found that EV ...

journal_title：Oncology letters

authors： Li Y,Guo X,Guo S,Wang Y,Chen L,Liu Y,Jia M,An J,Tao K,Xing J

更新日期：2020-09-01 00:00:00

abstract：:Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...

journal_title：Oncology letters

authors： Zhao Y,Han F,Zhang X,Zhou C,Huang D

更新日期：2020-10-01 00:00:00

abstract：:Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...

journal_title：Oncology letters

authors： Cui L,Xu L,Wang G,Wen J,Luo L,Zhao H,Chen S,Zheng M,Sun C,Jin X,Yang L

更新日期：2020-10-01 00:00:00

abstract：:The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...

journal_title：Oncology letters

authors： Kobayashi J,Fujimoto D,Murakami M,Hirono Y,Goi T

更新日期：2018-06-01 00:00:00

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of overexpression of interferon-induced transmembrane protein 5 (IFITM5) and IFITM5 c.-14C>T mutation on osteogenic differentiation, and the proliferation, migration and invasion of SaOS2 cells. SaOS2 cells were transfected with plasmids containing wild type IFITM5 (W...

journal_title：Oncology letters

authors： Liu BY,Lu YQ,Han F,Wang Y,Mo XK,Han JX

更新日期：2017-01-01 00:00:00

abstract：:The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...

journal_title：Oncology letters

authors： Cai LL,Wang J

更新日期：2019-06-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00