17AAG-induced internalisation of HER2-specific Affibody molecules.

abstract：:Breast cancer is the most common malignant tumor in women in the majority of countries, such as China, Britain and Australia, and its morbidity and mortality rates remain very high. Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) >200 nucleotides in length that lack open reading frames. LncRNA H19 is a tra...

journal_title：Oncology letters

authors： Wang J,Sun J,Yang F

更新日期：2020-01-01 00:00:00

abstract：:Notch signaling is well-known for its role in regulating cell self-renewal and differentiation. Within the cancer research field, it has been identified that dysregulated Notch signaling is involved directly with various types of cancer. Although Notch signaling is generally considered as oncogenic, it sometimes acts ...

journal_title：Oncology letters

authors： Jia D,Underwood J,Xu Q,Xie Q

更新日期：2019-06-01 00:00:00

abstract：:This study investigated whether microRNA-183 and microRNA-141 in nasopharyngeal carcinoma (NPC) lesions are potential risk factors for poor prognosis. A total of 317 NPC patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2010 to March 2015 were included. Reverse transcripti...

journal_title：Oncology letters

authors： Lian J,Li Y,Yu M

更新日期：2019-01-01 00:00:00

abstract：:Personalized chemotherapy with the use of biomarkers helps to maximize clinical efficiency. Therefore, the present study aimed to identify a potential method for identifying biomarkers in esophageal cancer. A total of 49 freshly resected tumor tissues and 72 paraffin-embedded specimens from patients with esophageal ca...

journal_title：Oncology letters

authors： Wei B,Wang J,Zhang X,Qian Z,Wu J,Sun Y,Han Q,Wan L,Zhu J,Gao Y,Chen X

更新日期：2017-12-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, including head and neck squamous cell carcinoma (HNSCC). Previously, TGFβ ligands were al...

journal_title：Oncology letters

authors： Bae WJ,Lee SH,Rho YS,Koo BS,Lim YC

更新日期：2016-12-01 00:00:00

abstract：:The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...

journal_title：Oncology letters

authors： Xiao YD,Paudel R,Liu H,Zhang B,Ma C,Zhou SK

更新日期：2015-03-01 00:00:00

abstract：:The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restrictio...

journal_title：Oncology letters

authors： Ma X,Yang C,Tang R,Xu Z,Zhang Z,Wang Y,Zhang J,Yang LI

更新日期：2015-07-01 00:00:00

abstract：:The present study aimed to investigate the association between excision repair cross-complementation group 1 (ERCC1) expression and clinical resistance to platinum-based chemotherapy or clinical characteristics, including survival time, in patients with epithelial ovarian cancer (EOC). ERCC1 expression was determined ...

journal_title：Oncology letters

authors： Du P,Wang Y,Chen L,Gan Y,Wu Q

更新日期：2016-08-01 00:00:00

abstract：:Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4...

journal_title：Oncology letters

authors： Zhao JA,Sang MX,Geng CZ,Wang SJ,Shan BE

更新日期：2016-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are enzymes for extracellular matrix remodeling that are involved in tumor growth, progression and metastasis. Among them, MMP-9 has been implicated in tumor angiogenesis. Tissue inhibitor of matrix metalloproteinase (TIMP)-2, a member of the family of MMP inhibitors, induces apoptosis...

journal_title：Oncology letters

authors： Wajner SM,Capp C,Brasil BA,Meurer L,Maia AL

更新日期：2014-03-01 00:00:00

abstract：:Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Que RS,Zhou CB,Zhan CN,Zhao JG,Chen LI

更新日期：2015-07-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

journal_title：Oncology letters

authors： He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

更新日期：2014-05-01 00:00:00

abstract：:The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...

journal_title：Oncology letters

authors： Higashiura Y,Kajihara H,Shigetomi H,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：:Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...

journal_title：Oncology letters

authors： Liu H,Li Y,Li J,Liu Y,Cui B

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to examine the impact of sarcopenia, defined as low muscle mass on computed tomography (CT), prior to sorafenib therapy on the clinical outcomes of patients with hepatocellular carcinoma (HCC) receiving sorafenib therapy. In total, 232 patients with unresectable HCC (median age, 72 years) were ...

journal_title：Oncology letters

authors： Nishikawa H,Nishijima N,Enomoto H,Sakamoto A,Nasu A,Komekado H,Nishimura T,Kita R,Kimura T,Iijima H,Nishiguchi S,Osaki Y

更新日期：2017-08-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and exp...

journal_title：Oncology letters

authors： Gu HZ,Lin RR,Wang HC,Zhu XJ,Hu Y,Zheng FY

更新日期：2017-05-01 00:00:00

abstract：:Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 ...

journal_title：Oncology letters

authors： Li M,Zhang XL,Deng F,Qian LT,Meng SP,Shan WL,Wang BL

更新日期：2016-11-01 00:00:00

abstract：:The outcomes of matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) remain controversial. The clinical outcome in patients that undergo transplantation following failed IST is typically poorer when compared with ...

journal_title：Oncology letters

authors： Hsu SN,Chen JH,Kao WY

更新日期：2014-10-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benig...

journal_title：Oncology letters

authors： Hong LZ,Wei XW,Chen JF,Shi Y

更新日期：2013-12-01 00:00:00

abstract：:Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...

journal_title：Oncology letters

authors： Chen X,Zhang Y,Wang F,Wang M,Teng W,Lin Y,Han X,Jin F,Xu Y,Cao P,Fang J,Zhu P,Tong C,Liu H

更新日期：2017-11-01 00:00:00

abstract：:Small supernumerary maker chromosome (sSMC) is a type of structurally abnormal chromosome. In order to identify the origin, morphology and other characteristics of sSMCs in children with mos 45,X/46,X,+mar karyotype, 17 patients (16 females and 1 male) were analyzed. All patients underwent general physical examination...

journal_title：Oncology letters

authors： Wang H,Wang T,Yang N,He Y,Chen L,Hong L,Shao X,Li H,Zhu H,Li H

更新日期：2017-06-01 00:00:00

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

journal_title：Oncology letters

authors： Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

更新日期：2012-10-01 00:00:00

abstract：:The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analys...

journal_title：Oncology letters

authors： Liu W,Liang Y,Bian C,Jiang L,Zheng G,Dong J

更新日期：2018-01-01 00:00:00

abstract：:Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...

journal_title：Oncology letters

authors： Guan N,Wang R,Feng X,Li C,Guo W

更新日期：2020-09-01 00:00:00

abstract：:Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...

journal_title：Oncology letters

authors： Togashi Y,Masago K,Ito Y,Sakamori Y,Okuda C,Fukuhara A,Nagai H,Kim YH,Mishima M

更新日期：2013-02-01 00:00:00

abstract：:The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expres...

journal_title：Oncology letters

authors： Kim HS,Hwang IG,Min HY,Bang YJ,Kim WH

更新日期：2019-05-01 00:00:00

abstract：:Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...

journal_title：Oncology letters

authors： Jiang L,Liu M,Cai X,Xie L,She F,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00