Identification of multiple pathways involved in the malignant transformation of endometriosis (Review).

abstract：:Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations...

journal_title：Oncology letters

authors： Hua B,Xu JY,Jiang L,Wang Z

更新日期：2015-09-01 00:00:00

abstract：:Factor that binds to the inducer of short transcripts of the human immunodeficiency virus-1 (FBI-1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI-1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI-1 express...

journal_title：Oncology letters

authors： Wang CJ,Chao CR,Liu HM,Zhu YY,Adell G,Jarlsfelt I,Zhang H,Sun XF

更新日期：2019-11-01 00:00:00

abstract：:Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...

journal_title：Oncology letters

authors： Ma J,Liang L,Liu H

更新日期：2012-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogene...

journal_title：Oncology letters

authors： Yang Y,Shen Z,Yan Y,Wang B,Zhang J,Shen C,Li T,Ye C,Gao Z,Peng G,Ye Y,Jiang K,Wang S

更新日期：2017-05-01 00:00:00

abstract：:Pleural effusion (PE) is a common manifestation associated with certain chest diseases. However, there is no effective diagnostic marker with high sensitivity and specificity. The aim of the present study was to evaluate the diagnostic performance of several biomarkers in the use of detecting malignant pleural disorde...

journal_title：Oncology letters

authors： Ji M,Zhu X,Dong J,Qian S,Meng F,Gu W,Qiu W

更新日期：2018-08-01 00:00:00

abstract：:DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the associati...

journal_title：Oncology letters

authors： Feng Y,Zhang H,Gao W,Wen S,Huangfu H,Sun R,Bai W,Wang B

更新日期：2014-10-01 00:00:00

abstract：:It has previously been reported that KU60019, as a highly effective radiosensitizer, inhibits the DNA damage response and blocks radiation-induced phosphorylation of key ataxia telangiectasia mutated targets in human glioma cells. The present study investigated whether KU60019 affects cell physiological activities and...

journal_title：Oncology letters

authors： Zhu Y,Mao C,Wu J,Li S,Ma R,Cao H,Ji M,Jing C,Tang J

更新日期：2014-11-01 00:00:00

abstract：:Multiple myeloma is defined as a malignant proliferation of a single clone of plasma cells resulting in monoclonal immunoglobulin production. Due to the number of plasma cell morphological variants, difficulty is often faced during morphological diagnosis. The current study describes the case of a 49-year-old woman pr...

journal_title：Oncology letters

authors： Jiang P,Xia W,Sun X,Dai X,Li L

更新日期：2016-03-01 00:00:00

abstract：:Changes in the expression of regulator of G protein signaling 2 (RGS2) are involved in the genesis and development of a number of malignancies. However, the association between changes in the expression of RGS2 and breast invasive carcinoma of no special type (BIC-NST) remains unknown. The present study found that, in...

journal_title：Oncology letters

authors： Wang C,Ye Q,Cao Y,Tan J,Wang F,Jiang J,Cao Y

更新日期：2018-01-01 00:00:00

abstract：:Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Breast imagi...

journal_title：Oncology letters

authors： Benej R,Mečiarová I,Pohlodek K

更新日期：2017-08-01 00:00:00

abstract：:Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...

journal_title：Oncology letters

authors： Öztürk H

更新日期：2015-03-01 00:00:00

abstract：:The use of 5α-reductase inhibitors (5α-RIs) as prostate cancer chemoprevention agents is controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial, have both shown a decreased incidence of prostate cancer in patient...

journal_title：Oncology letters

authors： Lacy JM,Kyprianou N

更新日期：2014-10-01 00:00:00

abstract：:Cancer and embryo expression protein 65 (CEP65) is a centrosomal protein that is expressed at relatively high levels in embryonic tissue and different cancerous tissues, but its role in tumorigenesis remains unknown. In the present study, CEP65 was stably expressed in AGS gastric cancer cells. CEP65 was found to promo...

journal_title：Oncology letters

authors： Jin G,Peng L,Zhang J,Qu L,Shou C

更新日期：2015-04-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...

journal_title：Oncology letters

authors： Meng L,Liu B,Ji R,Jiang X,Yan X,Xin Y

更新日期：2019-02-01 00:00:00

abstract：:Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...

journal_title：Oncology letters

authors： Wang ZP,Tian Y,Lin J

更新日期：2017-10-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...

journal_title：Oncology letters

authors： Tian W,Hu W,Shi X,Liu P,Ma X,Zhao W,Qu L,Zhang S,Shi W,Liu A,Cao J

更新日期：2020-04-01 00:00:00

abstract：:This study aimed to investigate the clinicopathological characteristics, differential diagnosis and prognosis of pulmonary epithelioid hemangioendothelioma (PEH). PEH is a rare low-grade malignant vascular tumor. The cause of PEH remains unclear. Patient prognosis is unpredictable, with life expectancy ranging from 1 ...

journal_title：Oncology letters

authors： Shao J,Zhang J

更新日期：2014-12-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Primary smooth muscle tumors of the thyroid gland are extremely rare neoplasms. Due to their rarity, clinical case studies concerning management are lacking. According to a literature review, only 19 cases of primary thyroid leiomyosarcomas (TLs) have been reported. In the majority of patients, the prognosis is poor s...

journal_title：Oncology letters

authors： Conzo G,Candela G,Tartaglia E,Gambardella C,Mauriello C,Pettinato G,Bellastella G,Esposito K,Santini L

更新日期：2014-04-01 00:00:00

abstract：:MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellul...

journal_title：Oncology letters

authors： Wang W,Zhang H,Tang M,Liu L,Zhou Z,Zhang S,Wang L

更新日期：2017-05-01 00:00:00

abstract：:Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the pr...

journal_title：Oncology letters

authors： Yang T,Mao P,Chen X,Niu X,Xu G,Bai X,Xie W

更新日期：2019-02-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...

journal_title：Oncology letters

authors： Banik BK,Mukhopadhyay C,Becker FF

更新日期：2010-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally considered one of the most common gastrointestinal malignant tumors, characterized by high invasiveness and metastatic rate, as well as insidious onset. A relationship between carcinogenicity and aberrant microRNA-139-5p (miR-139-5p) expression has been identified in multipl...

journal_title：Oncology letters

authors： Qin H,Wen DY,Que Q,Zhou CY,Wang XD,Peng YT,He Y,Yang H,Liao BM

更新日期：2019-12-01 00:00:00

abstract：:Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosp...

journal_title：Oncology letters

authors： Gan Y,Chen Q,Lei Y

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to examine the associations between the protein and mRNA expression levels of ovarian cancer gene 1 (OVCA1), cyclin D1 and p16 and high-risk human papillomavirus (HR-HPV) infection in cervical lesions. The protein expression levels of OVCA1, cyclin D1 and p16 in 66 cases of cervical cancer, 64 ...

journal_title：Oncology letters

authors： Tong R,Yang Q,Wang C,Bi F,Jiang B

更新日期：2017-05-01 00:00:00

abstract：:Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painles...

journal_title：Oncology letters

authors： Gong Z,Zhang Y,Chu H,Lian P,Zhang L,Sun P,Chen J

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between H-ras mutation and primary hepatocellular carcinoma (HCC) and to describe the role of H-ras mutation in carcinogenesis. Clinical samples of 69 patients were collected and the expression levels of H-ras in HCC and the surrounding normal tissues were exami...

journal_title：Oncology letters

authors： Sui G,Ma X,Liu S,Niu H,Dong Q

更新日期：2012-10-01 00:00:00

abstract：:Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated the functional role of miR-525 in CHS tissues and cells. In the present study, it was discovered that miR-525 levels were decreased in CHS tissues ...

journal_title：Oncology letters

authors： Liu B,Song X,Yan Z,Yang H,Shi Y,Wu J

更新日期：2019-01-01 00:00:00

abstract：:Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...

journal_title：Oncology letters

authors： Jaœkiewicz K,Iżycka-Œwieszewska E,Janiak M,Lysiak-Szydłowska W,Adrych K,Reinartz J,Jankun J,Skrzypczak-Jankun E

更新日期：2010-09-01 00:00:00