Increased expression of hepcidin and associated upregulation of JAK/STAT3 signaling in human gastric cancer.

abstract：:The present study investigated the potential anticancer activity of the bark of Mangifera zeylanica, an endemic plant in Sri Lanka that has been traditionally used for cancer therapy. Cytotoxic and apoptotic effects were investigated in vitro using sulphorodamine assay, acridine orange and ethidium bromide staining, c...

journal_title：Oncology letters

authors： Ediriweera MK,Tennekoon KH,Samarakoon SR,Thabrew I,Dilip DE Silva E

更新日期：2016-02-01 00:00:00

abstract：:The clinicopathological value and exploration of the potential molecular mechanism of microRNA-183-5p (miR-183-5p) have been investigated in various cancers; however, to the best of the author's knowledge, no similar research has been reported for bladder cancer. In the present study, it was revealed that the expressi...

journal_title：Oncology letters

authors： Gao JM,Huang LZ,Huang ZG,He RQ

更新日期：2018-04-01 00:00:00

abstract：:The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...

journal_title：Oncology letters

authors： Zhou Z,Ware JH,Kennedy AR

更新日期：2011-09-01 00:00:00

abstract：:Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...

journal_title：Oncology letters

authors： Wang Y,Qian H,Wang J

更新日期：2015-12-01 00:00:00

abstract：:Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uter...

journal_title：Oncology letters

authors： Wang Y,Ikeda JI,Rahadiani N,Mamat S,Ueda Y,Tian T,Enomoto T,Kimura T,Aozasa K,Morii E

更新日期：2012-01-01 00:00:00

abstract：:Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...

journal_title：Oncology letters

authors： He D,Yan L,Ma X,Cheng Y,Wu S,Zuo J,Park EJ,Liu J,Wu M,Choi JI,Tong H

更新日期：2020-10-01 00:00:00

abstract：:Human lactoferrin (hLF) is a multifunctional glycoprotein that inhibits cancer growth. However, the inhibitory effect of this glycoprotein in cervical cancer remains inconclusive. This study investigated the efficacy of hLF on the inhibition of U14 cervical cancer in vivo. Recombinant adenovirus carrying hLF (Ad-hLF) ...

journal_title：Oncology letters

authors： Shi H,Li W

更新日期：2014-03-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...

journal_title：Oncology letters

authors： Haralambiev L,Wien L,Gelbrich N,Lange J,Bakir S,Kramer A,Burchardt M,Ekkernkamp A,Gümbel D,Stope MB

更新日期：2020-01-01 00:00:00

abstract：:KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...

journal_title：Oncology letters

authors： Lee HS,Hwang DY,Han HS

更新日期：2020-07-01 00:00:00

abstract：:Cross-talk between competing endogenous RNAs (ceRNAs) play key roles in tumor development. In this study, we performed exon-level expression profiling on 26 glioblastomas (GBMs) and 6 controls to identify long non-coding RNAs (lncRNAs) of GBM initiation and progression using lncRNA-mediated ceRNA network (LMCN). The m...

journal_title：Oncology letters

authors： Zan XY,Li L

更新日期：2019-05-01 00:00:00

abstract：:The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...

journal_title：Oncology letters

authors： Yin SP,Gao Y,Xie XS,Xu DD,Riabov V,Du WD

更新日期：2020-03-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous report...

journal_title：Oncology letters

authors： Fujii T,Sakai E,Takahashi H,Yamada E,Ohkubo H,Higurashi T,Nakajima A

更新日期：2017-06-01 00:00:00

abstract：:Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

journal_title：Oncology letters

authors： Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:Plant secondary metabolites including alkaloids, demonstrate a complex diversity in their molecular scaffolds and exhibit tremendous pharmacological potential as anti-cancerous therapeutics. The present study aimed to evaluate the anticancer activity of a natural alkaloid, mecambridine, against human oral squamous cel...

journal_title：Oncology letters

authors： Lin N,Li Z,Wang D,Zheng K,Wu Y,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it exerts several ben...

journal_title：Oncology letters

authors： Aziz MY,Omar AR,Subramani T,Yeap SK,Ho WY,Ismail NH,Ahmad S,Alitheen NB

更新日期：2014-05-01 00:00:00

abstract：:The present study aimed to assess the feasibility, safety and efficiency of ultrasound-guided percutaneous microwave ablation (MWA) on liver metastases from colon or rectal cancer. Patients who received MWA therapy for liver metastases from colon or rectal cancer between June 2009 and May 2012 were enrolled in the stu...

journal_title：Oncology letters

authors： Wang J,Liang P,Yu J,Yu MA,Liu F,Cheng Z,Yu X

更新日期：2014-07-01 00:00:00

abstract：:5,7-dihydroxy-3',4',6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidate...

journal_title：Oncology letters

authors： Li YY,Wu H,Dong YG,Lin BO,Xu G,Ma YB

更新日期：2015-10-01 00:00:00

abstract：:In recent decades, thyroid cancer (TC) has become one of the most common endocrine malignancies. Next-generation sequencing of paired TC and adjacent healthy thyroid tissues demonstrated that polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) may serve as a tumour suppressor gene in thyroid cancer. However, the ...

journal_title：Oncology letters

authors： Zheng C,Quan R,Xia EJ,Bhandari A,Zhang X

更新日期：2019-09-01 00:00:00

abstract：:Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...

journal_title：Oncology letters

authors： Huang J,Peng X,Zhang K,Li C,Su B,Zhang Y,Yu W

更新日期：2017-11-01 00:00:00

abstract：:The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...

journal_title：Oncology letters

authors： Xiang L,Dong W,Wang R,Wei J,Qiu G,Cen J,Chen Z,Zheng X,Hu S,Xie X,Cao X,Gu W

更新日期：2014-07-01 00:00:00

abstract：:Linked color imaging (LCI) is a novel endoscopic system used to increase color contrast. As LCI does not decrease luminal brightness, it may improve the detection of colonic neoplasms. However, the extent to which LCI improves the visibility of colonic polyps has not yet been determined. Between December 2016 and May ...

journal_title：Oncology letters

authors： Tanaka Y,Inoue T,Kakimoto K,Nakazawa K,Tawa H,Hirata Y,Okada T,Nouda S,Kawakami K,Takeuchi T,Egashira Y,Higuchi K

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and function of forkhead box protein 3 (FOXP3) in gastric cancer using a rat model. A total of 92 Wistar rats were divided into two groups: An experimental group (n=46) and a control group (n=46). In the experimental group, sarcosine ethyl ester hydrochlor...

journal_title：Oncology letters

authors： Guo G,He Z,Shi Z

更新日期：2016-08-01 00:00:00

abstract：:Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...

journal_title：Oncology letters

authors： Gao X,Wang M,Zhang Y,Xu Z,Ding J,Tang J

更新日期：2019-09-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...

journal_title：Oncology letters

authors： Tanaka K,Oshikawa G,Akiyama H,Ishida S,Nagao T,Yamamoto M,Miura O

更新日期：2017-07-01 00:00:00

abstract：:A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...

journal_title：Oncology letters

authors： Kim DD,Yang CS,Chae HD,Kwak SG,Jeon CH

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to compare the clinical characteristics of acute lymphoblastic leukemia (ALL) that occurred in male and female patients at one institution in Southern China. The medical electronic records of Nanfang Hospital, affiliated to Southern Medical University, were searched for patients with a...

journal_title：Oncology letters

authors： Li SY,Ye JY,Meng FY,Li CF,Yang MO

更新日期：2015-07-01 00:00:00

abstract：:The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...

journal_title：Oncology letters

authors： Xu L,Zeng Z,Chen B,Wu X,Yu J,Xue L,Tian L,Wang Y,Chen M,Sung JJ,Hu P

更新日期：2011-03-01 00:00:00

abstract：:In the present study, we analyzed the supra-additive effect of oxaliplatin in combination with gemcitabine on terminal colorectal cancer and its influence on high-mobility group box 1 (HMGB1) expression. A total of 86 patients with terminal colorectal cancer were enrolled in this study. Patients received oxaliplatin i...

journal_title：Oncology letters

authors： Wen S,Du X,Gou Y,Jiang L

更新日期：2016-11-01 00:00:00