Abstract:
:Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous reports. A endoscopist proficient in ACF counting performed high-magnification chromoscopic colonoscopy in 45 subjects and investigated the distribution of ACF in four bowel segments (middle Houston valve to the dentate line and distal rectum 0-5, 5-10 and 10-15 cm). We also investigated whether the patient physique might affect the distance from the middle Houston valve to the dentate line. The prevalence of ACF was 84% and most of the ACF (170/210, 81%) were located in the bowel segment from the middle Houston valve to the dentate line. The number of ACF was significantly correlated with the bowel segment in which the counting was performed: Dentate line to the middle Houston valve and distal rectum within 0-15 cm (r=0.94, P<0.001). The patient physique did not affect the distance from the middle Houston valve to the dentate line. In conclusion, the definition of the ACF counting area may not affect the results of ACF counting.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Fujii T,Sakai E,Takahashi H,Yamada E,Ohkubo H,Higurashi T,Nakajima Adoi
10.3892/ol.2017.6003subject
Has Abstractpub_date
2017-06-01 00:00:00pages
4501-4504issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-6003journal_volume
13pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11829
更新日期:2020-09-01 00:00:00
abstract::Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10956
更新日期:2019-12-01 00:00:00
abstract::Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000086
更新日期:2010-05-01 00:00:00
abstract::Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD1...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.981
更新日期:2013-01-01 00:00:00
abstract::The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3515
更新日期:2015-10-01 00:00:00
abstract::Xeroderma pigmentosum variant (XP-V) is a subtype of xeroderma pigmentosum (XP) disease with typical pigmentation and types of cancer in the oral maxillofacial and other sun-exposed regions. Few factors of tumor proneness in XP-V have been completely elucidated with the exception of the POLH [which encodes DNA polymer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1604
更新日期:2013-12-01 00:00:00
abstract::It is crucial to classify cervical lesions into high-grade squamous intraepithelial lesions (HSILs) and low-grade SILs (LSILs), as LSILs are conservatively treated by observation, based on an expectation of natural regression, whereas HSILs usually require electrosurgical excision. In the present study, peripheral blo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11779
更新日期:2020-09-01 00:00:00
abstract::Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6479
更新日期:2017-09-01 00:00:00
abstract::Small cell carcinoma of the rectum is extremely rare. The present study aimed to improve the recognition of computed tomography (CT) and magnetic resonance imaging (MRI) features observed in patients with small cell carcinoma of the rectum. A total of 4 cases of patients with histologically confirmed small cell carcin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4136
更新日期:2016-03-01 00:00:00
abstract::MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8557
更新日期:2018-06-01 00:00:00
abstract::Several previous studies have shown that mutations in B-Raf proto-oncogene (BRAF) and telomerase reverse transcriptase (TERT) can be used for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). However, whether mutations in BRAF and the TERT promoter may improve the accurate identification and risk strat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11904
更新日期:2020-10-01 00:00:00
abstract::Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10696
更新日期:2019-10-01 00:00:00
abstract::The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5477
更新日期:2017-02-01 00:00:00
abstract::The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9119
更新日期:2018-09-01 00:00:00
abstract::Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5906
更新日期:2017-05-01 00:00:00
abstract::An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1492
更新日期:2013-10-01 00:00:00
abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9322
更新日期:2018-10-01 00:00:00
abstract::To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5281
更新日期:2016-12-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy affecting pediatric and adult populations. Although the outcomes of ALL in children have improved markedly in previous years, limited treatment strategies are available at present for adult patients with ALL. Wee1 is a crucial cell cycle checkp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9291
更新日期:2018-10-01 00:00:00
abstract::Epithelial ovarian cancer has the highest mortality of all gynecological cancers, and its progression is often without symptoms. Clinical outcome and survival may be improved if the disease is identified in the early stages. The objective of the study was to evaluate the utility of the serum biomarkers human epididymi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.757
更新日期:2012-09-01 00:00:00
abstract::High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11170
更新日期:2020-01-01 00:00:00
abstract::Increasing number of microRNAs (miRNAs) have been reported to play an important role in the development and progression of non-small cell lung cancer (NSCLC). In particular, microRNA-497-5p (miR-497-5p) has been proposed as a tumor suppressor miRNA in human cancers. However, the role of miR-497-5p and its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9954
更新日期:2019-03-01 00:00:00
abstract::LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10473
更新日期:2019-08-01 00:00:00
abstract::Breast cancer is the second leading cause of cancer-associated mortality in females in the USA. Hsa-miR-599 was demonstrated to function as a tumour suppressor during cancer progression. However, the function and mechanism of the hsa-miR-599 in human breast cancer remain elusive. Thus, the aim of the present study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6651
更新日期:2017-09-01 00:00:00
abstract::The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8202
更新日期:2018-05-01 00:00:00
abstract::The present study aimed to investigate the expression levels and clinical value of miR-365 and miR-25 in serum of patients with non-small cell lung cancer (NSCLC). Patients (180) diagnosed with NSCLC at the Affiliated Hospital of Guangdong Medical University from July 2011 to December 2013 were used as the experimenta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12053
更新日期:2020-11-01 00:00:00
abstract::Bladder cancer is one of the most common forms of malignancies involving the urinary system and multiple risk factors have been associated with its etiology. The most common of which include cigarette smoking and various occupational or chemical exposures. It is usually diagnosed in older individuals with an average a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4355
更新日期:2016-05-01 00:00:00
abstract::The present study aims to quantitatively measure adiposity-related image features and to test the feasibility of applying multivariate statistical data analysis-based prediction models to generate a novel clinical marker and predict the benefit of epithelial ovarian cancer (EOC) patients with and without maintenance b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4648
更新日期:2016-07-01 00:00:00
abstract::Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves an important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression of RACK1 in gastric cancer (GC), and its association with the occurrence and development of GC. In ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6741
更新日期:2017-10-01 00:00:00
abstract::The aim of this study was to construct the eukaryotic expression vector pEGFP-N1-hPer2 and assess its expression in the human osteosarcoma cell line MG63. Total mRNA was extracted from human osteosarcoma MG63 cells, the human period 2 (hPer2) gene was obtained by reverse transcription-polymerase chain reaction (RT-PCR...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4291
更新日期:2016-04-01 00:00:00