Bladder cancer in a young patient: Undiscovered risk factors.

abstract：:Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...

journal_title：Oncology letters

authors： Yuan YJ,Zhou P,Xia F,Zhang XB,He SS,Guo DY,Xing YH,Zhao HW

更新日期：2020-10-01 00:00:00

abstract：:Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-as...

journal_title：Oncology letters

authors： Gao B,Li S,Tan Z,Ma L,Liu J

更新日期：2019-02-01 00:00:00

abstract：:Gastric cancer is one of leading causes of cancer-related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern tech...

journal_title：Oncology letters

authors： Jin Z,Jiang W,Wang L

更新日期：2015-04-01 00:00:00

abstract：:Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...

journal_title：Oncology letters

authors： Ke X,Chen C,Song Y,Cai Q,Li J,Tang Y,Han X,Qu W,Chen A,Wang H,Xu G,Liu D

更新日期：2019-12-01 00:00:00

abstract：:Arteriosclerosis poses a significant risk to human health and involves the thickening and hardening of the walls of arteries. Accumulated evidence demonstrates that aberrant proliferation of vascular smooth muscle cells (VSMCs) accounts for the onset and progression of arteriosclerosis. Suppression of their proliferat...

journal_title：Oncology letters

authors： Han D,Zhang X,Zhang J,Guo X,Zheng Y,Sui S,Zheng J

更新日期：2016-11-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of cancer-associated mortality in the world. In previous years, almost no significant advancements have been made towards the molecular characterization of NSCLC, which highlights the requirement for novel target genes. Hypoxia inducibl...

journal_title：Oncology letters

authors： Qian J,Bai H,Gao Z,Dong YU,Pei J,Ma M,Han B

更新日期：2016-03-01 00:00:00

abstract：:The present study aimed to investigate the association between excision repair cross-complementation group 1 (ERCC1) expression and clinical resistance to platinum-based chemotherapy or clinical characteristics, including survival time, in patients with epithelial ovarian cancer (EOC). ERCC1 expression was determined ...

journal_title：Oncology letters

authors： Du P,Wang Y,Chen L,Gan Y,Wu Q

更新日期：2016-08-01 00:00:00

abstract：:Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...

journal_title：Oncology letters

authors： Liu Z,Tian Q,Xia S,Yin H,Yao D,Xiu Y

更新日期：2016-02-01 00:00:00

abstract：:Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...

journal_title：Oncology letters

authors： Köllermann J,Albrecht H,Schlomm T,Huland H,Graefen M,Bokemeyer C,Simon R,Sauter G,Wilczak W

更新日期：2010-07-01 00:00:00

abstract：:Gastric cancer is a common malignancy in China, with the second highest mortality rate worldwide. Advanced gastric cancer usually exhibits a poor prognosis with a low 5-year survival rate. Therefore, developing novel drugs for the treatment of this cancer will be beneficial for patients. Demethylzeylasteral, an extrac...

journal_title：Oncology letters

authors： Yang Y,Zhao M,Hu T,Su F,Qian F,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:Plant secondary metabolites including alkaloids, demonstrate a complex diversity in their molecular scaffolds and exhibit tremendous pharmacological potential as anti-cancerous therapeutics. The present study aimed to evaluate the anticancer activity of a natural alkaloid, mecambridine, against human oral squamous cel...

journal_title：Oncology letters

authors： Lin N,Li Z,Wang D,Zheng K,Wu Y,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...

journal_title：Oncology letters

authors： Lu K,Shen H,Zhu S,Bi S,Wu S

更新日期：2018-08-01 00:00:00

abstract：:Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologi...

journal_title：Oncology letters

authors： Antohe M,Nedelcu RI,Nichita L,Popp CG,Cioplea M,Brinzea A,Hodorogea A,Calinescu A,Balaban M,Ion DA,Diaconu C,Bleotu C,Pirici D,Zurac SA,Turcu G

更新日期：2019-05-01 00:00:00

abstract：:MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...

journal_title：Oncology letters

authors： Wang G,Zhao R,Zhao X,Chen XI,Wang D,Jin Y,Liu XI,Zhao CI,Zhu Y,Ren C,Li M,Jin X,Zhang F,Zhong Z,Wang T,Li X

更新日期：2015-11-01 00:00:00

abstract：:The standard treatment for advanced hepatocellular carcinoma (HCC) is sorafenib, a multikinase inhibitor of tumor cell proliferation and angiogenesis. Hyperthermia inhibits angiogenesis and promotes apoptosis. Potential synergic antiangiogenic and proapoptotic effects represent the rationale for combining sorafenib wi...

journal_title：Oncology letters

authors： Gadaleta-Caldarola G,Infusino S,Galise I,Ranieri G,Vinciarelli G,Fazio V,Divella R,Daniele A,Filippelli G,Gadaleta CD

更新日期：2014-10-01 00:00:00

abstract：:Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in ...

journal_title：Oncology letters

authors： Yamamoto M,Suzuki SO,Himeno M

更新日期：2010-05-01 00:00:00

abstract：:Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosp...

journal_title：Oncology letters

authors： Gan Y,Chen Q,Lei Y

更新日期：2017-10-01 00:00:00

abstract：:Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...

journal_title：Oncology letters

authors： Mendoza-Almanza G,Ortíz-Sánchez E,Rocha-Zavaleta L,Rivas-Santiago C,Esparza-Ibarra E,Olmos J

更新日期：2019-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide; therefore, there is an emerging need for novel experimental models that allow for the identification and validation of biomarkers for CRC-specific progression. In the present study, a repeated sphere-forming assay was used as a strate...

journal_title：Oncology letters

authors： Lai PL,Chen TC,Feng CY,Lin H,Ng CH,Chen Y,Hsiao M,Lu J,Huang HC

更新日期：2020-09-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:The correlation between expression and prognosis of thyroid transcription factor-1 (TTF-1) and CD44v6 in undifferentiated lung carcinoma was investigated. There were 116 cases with large cell undifferentiated carcinoma in group A, 120 cases with small cell undifferentiated carcinoma in group B and 80 normal individual...

journal_title：Oncology letters

authors： Wu Y,Yu X,Liang M,Wang B

更新日期：2019-10-01 00:00:00

abstract：:Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...

journal_title：Oncology letters

authors： Liu H,Li WZ,Wang XY,Pei YG,Long XY,Chen CY,Hu YB

更新日期：2015-02-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible...

journal_title：Oncology letters

authors： Morimoto T,Takenaka S,Hashimoto N,Araki N,Myoui A,Yoshikawa H

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...

journal_title：Oncology letters

authors： Huang JX,Shen SL,Lin M,Xiao W,Chen WC,Lin MS,Yu H,Chen P,Qian RY

更新日期：2012-10-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a ...

journal_title：Oncology letters

authors： Peng Y,Liu Q,Wang Y,Song A,Duan H,Qiu Y,Li Q,Cui HJ

更新日期：2019-08-01 00:00:00

abstract：:Although a combination of platinum- and taxane-based chemotherapy is recommended for at least 70% patients with ovarian cancer as treatment subsequent to surgery, the initial response to the chemotherapy is not durable and tumors become resistant. Histone deacetylase and proteasome inhibitors are novel therapeutic age...

journal_title：Oncology letters

authors： Jin X,Fang Y,Hu Y,Chen J,Liu W,Chen G,Gong M,Wu P,Zhu T,Wang S,Zhou J,Wang H,Ma D,Li K

更新日期：2017-06-01 00:00:00

abstract：:Sarcomatoid carcinomas exhibit features that are common to epithelial and mesenchymal tumors. These carcinomas are rare, particularly in the small intestine. In the current case report, we describe a case of an intestinal sarcomatoid carcinoma in a 70-year-old Chinese female. Sarcomatoid carcinoma was confirmed based ...

journal_title：Oncology letters

authors： Han N,Han QH,Liu YZ,Li ZC,Li J

更新日期：2013-08-01 00:00:00

abstract：:In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...

journal_title：Oncology letters

authors： Yan Y,Wu Q,Li ZY,Bu ZD,Ji JF

更新日期：2019-03-01 00:00:00

abstract：:Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...

journal_title：Oncology letters

authors： Kadochi Y,Mori S,Fujiwara-Tani R,Luo Y,Nishiguchi Y,Kishi S,Fujii K,Ohmori H,Kuniyasu H

更新日期：2017-07-01 00:00:00