Intranasal dexmedetomidine combined with local anesthesia for conscious sedation during breast lumpectomy: A prospective randomized trial.

Abstract:

:Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious sedation with intranasal dexmedetomidine combined with local anesthesia in breast lumpectomy, and to identify its optimal dose. A prospective randomized, double-blinded, placebo-controlled, single-center study was designed, and patients undergoing breast lumpectomies were recruited based on the inclusion and exclusion criteria. All patients were randomly allocated to four groups: i) Local anesthesia with 0.9% intranasal saline (placebo); local anesthesia with ii) 1 µg.kg-1; iii) 1.5 µg.kg-1; or iv) 2 µg.kg-1 intranasal dexmedetomidine. The sedation status, pain relief, vital signs, adverse events, and satisfaction of patient and surgeon were recorded. Patients in the three dexmedetomidine groups were significantly more sedated and experienced less pain compared with the placebo group 45 min after intranasal dexmedetomidine administration and during 30 min in the post-anesthesia care unit. Patients in the 1.5 µg.kg-1 group were more sedated compared with the 1 µg.kg-1 group (without reaching statistical significance), whereas the 1.5 µg.kg-1 group exhibited a similar level of sedation 45 min after intranasal dexmedetomidine administration compared with the 2 µg.kg-1 group. In addition, patients in the 1 and 1.5 µg.kg-1 group experienced no adverse hemodynamic effects. Patient and surgeon satisfaction were greater in the 1.5 µg.kg-1 group compared with the 1 and 2 µg.kg-1 groups. Taken together, the results of the present study suggested that conscious sedation with intranasal dexmedetomidine and local anesthesia may be an effective anesthetic for breast lumpectomy surgery, and that the optimal dose for intranasal dexmedetomidine administration may be 1.5 µg.kg-1, as it resulted in good sedation and patient satisfaction without adverse effects.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Yuan YJ,Zhou P,Xia F,Zhang XB,He SS,Guo DY,Xing YH,Zhao HW

doi

10.3892/ol.2020.11938

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

77

issue

4

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-11938

journal_volume

20

pub_type

杂志文章
  • KLF5 promotes apoptosis induced by phorbol ester as an effector of the autocrine factor TNFα in LNCaP prostate cancer cells.

    abstract::Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6293

    authors: Shi Q,Jia J,Hui K,Gao Y,Xu S,Guan B,Tang X,Wang X,He D,Guo P

    更新日期:2017-08-01 00:00:00

  • Low neutrophil-lymphocyte ratio correlates with extended survival in patients with metastatic breast cancer who achieved clinically complete response following multidisciplinary therapy: A retrospective study.

    abstract::The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8145

    authors: Takuwa H,Tsuji W,Yamamoto Y,Shintaku M,Yotsumoto F

    更新日期:2018-05-01 00:00:00

  • Trisomy chromosome 5 is a recurrent cytogenetic lesion in mammary tumors from parous MMTV-erbB-2 transgenic mice.

    abstract::erbB-2 is amplified or overexpressed in approximately 30% of human breast cancers, and has been associated with poor prognosis and therapeutic resistance. Previous studies have suggested that erbB-2 overexpression in transgenic mice induces genomic instability; however, the patterns of genetic lesions vary with indivi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.373

    authors: Kim YM,Ma Z,Lee S,Lee J,Li S,Yang X

    更新日期:2011-11-01 00:00:00

  • Inflammatory biomarkers in prognostic analysis for patients with glioma and the establishment of a nomogram.

    abstract::Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the pr...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9870

    authors: Yang T,Mao P,Chen X,Niu X,Xu G,Bai X,Xie W

    更新日期:2019-02-01 00:00:00

  • Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade.

    abstract::The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). A total of 99 patients with early T-stage tongue SCC of any clinical N status who receiv...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11358

    authors: Hamada M,Ebihara Y,Nagata K,Yano M,Kogashiwa Y,Nakahira M,Sugasawa M,Nagatsuka H,Yasuda M

    更新日期:2020-04-01 00:00:00

  • Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung.

    abstract::In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent c...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1763

    authors: Imura J,Abe K,Uchida Y,Shibata M,Tsunematsu K,Sathoh M,Miwa S,Nakajima T,Nomoto K,Hayashi S,Tsuneyama K

    更新日期:2014-03-01 00:00:00

  • Tricholemmal carcinoma of the head and neck region: A report of 15 cases.

    abstract::Tricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 pati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1726

    authors: Feng Z,Zhu HG,Wang LZ,Zheng JW,Chen WT,Zhang Z,Dong W,Qu W,Wang YA

    更新日期:2014-02-01 00:00:00

  • Reduced tissue inhibitor of metalloproteinase-2 expression is associated with advanced medullary thyroid carcinoma.

    abstract::Matrix metalloproteinases (MMPs) are enzymes for extracellular matrix remodeling that are involved in tumor growth, progression and metastasis. Among them, MMP-9 has been implicated in tumor angiogenesis. Tissue inhibitor of matrix metalloproteinase (TIMP)-2, a member of the family of MMP inhibitors, induces apoptosis...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1767

    authors: Wajner SM,Capp C,Brasil BA,Meurer L,Maia AL

    更新日期:2014-03-01 00:00:00

  • Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21.

    abstract::Nordihydroguaiaretic acid (NDGA) and its derivatives possess anti-cancer effects on various types of cancer via the induction of apoptosis or cell cycle arrest. This study proved that NDGA inhibited cervical cancer SiHa cell growth and induced cell cycle arrest at the G(1) phase, which may be a consequence of cell cyc...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2010.205

    authors: Gao P,Zhai F,Guan L,Zheng J

    更新日期:2011-01-01 00:00:00

  • All-trans retinoic acid enhances the effect of 5-aza-2'-deoxycytidine on p16INK4a demethylation, and the two drugs synergistically activate retinoic acid receptor β gene expression in the human erythroleukemia K562 cell line.

    abstract::The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2133

    authors: Xiang L,Dong W,Wang R,Wei J,Qiu G,Cen J,Chen Z,Zheng X,Hu S,Xie X,Cao X,Gu W

    更新日期:2014-07-01 00:00:00

  • Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study.

    abstract::The transforming growth factor-β (TGFβ) pathway plays an important role in various types of human cancer. However, the role of TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms in gastric cancer is controversial. We aimed to investigate the associations between these polymorphisms and gastric cancer susceptibility, clini...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.249

    authors: Xu L,Zeng Z,Chen B,Wu X,Yu J,Xue L,Tian L,Wang Y,Chen M,Sung JJ,Hu P

    更新日期:2011-03-01 00:00:00

  • Application of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry technology for the diagnosis of colorectal adenoma.

    abstract::The aim of the present study was to identify a specific biological marker for the diagnosis of colorectal adenomas through the analysis of variations in serum protein profiling in colorectal adenoma patients. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between September 2011 and M...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1304

    authors: Zhou ZY,Tao DD,Cao JW,Luo HS

    更新日期:2013-06-01 00:00:00

  • Biological intensity-modulated radiotherapy plus neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer: A case report.

    abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2820

    authors: Huang S,Dang Y,Li F,Wei W,Ma Y,Qiao S,Wang Q

    更新日期:2015-03-01 00:00:00

  • MicroRNA-183 inhibits A375 human melanoma cell migration and invasion by targeting Ezrin and MMP-9.

    abstract::To assess the influence of microRNA-183 (miR-183) on the migration and invasion of A375 human melanoma cells, an A375 cell line with stable miR-183 overexpression or knockdown was constructed using lentiviral transfection. The change of miR-183 expression in these cells and in non-transfected controls was verified usi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9603

    authors: Zhang Y,Wang G

    更新日期:2019-01-01 00:00:00

  • microRNA-497 overexpression decreases proliferation, migration and invasion of human retinoblastoma cells via targeting vascular endothelial growth factor A.

    abstract::The expression level and roles of microRNA-497 (miR-497) have been frequently reported in previous studies on cancer. However, its expression, function and associated molecular mechanisms in retinoblastoma remain unknown. In the present study, miR-497 expression levels in human retinoblastoma tissues, normal retinal t...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6083

    authors: Li J,Zhang Y,Wang X,Zhao R

    更新日期:2017-06-01 00:00:00

  • Morphological response contributes to patient selection for rescue liver resection in chemotherapy patients with initially un-resectable colorectal liver metastasis.

    abstract::Morphological response is considered an improved surrogate to the Response Evaluation Criteria in Solid Tumors (RECIST) model with regard to predicting the prognosis for patients with colorectal liver metastases. However, its use as a decision-making tool for surgical intervention has not been examined. The present st...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6338

    authors: Suzuki K,Muto Y,Ichida K,Fukui T,Takayama Y,Kakizawa N,Kato T,Hasegawa F,Watanabe F,Kaneda Y,Kikukawa R,Saito M,Tsujinaka S,Futsuhara K,Takata O,Noda H,Miyakura Y,Kiyozaki H,Konishi F,Rikiyama T

    更新日期:2017-08-01 00:00:00

  • Clinical and computed tomography imaging features of renal medullary carcinoma: A report of six cases.

    abstract::Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literatur...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3891

    authors: Shi Z,Zhuang Q,You R,Li Y,Li J,Cao D

    更新日期:2016-01-01 00:00:00

  • Prognostic value of ATAD3 gene cluster expression in hepatocellular carcinoma.

    abstract::ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10454

    authors: Liu X,Li G,Ai L,Ye Q,Yu T,Yang B

    更新日期:2019-08-01 00:00:00

  • Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review.

    abstract::Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3511

    authors: Hu J,Hong X,Li Z,Lu Q

    更新日期:2015-10-01 00:00:00

  • miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer.

    abstract::There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8997

    authors: Jiang X,Wang Z

    更新日期:2018-09-01 00:00:00

  • Development of hepatocellular carcinoma in patients with chronic hepatitis C more than 10 years after sustained virological response to interferon therapy.

    abstract::The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol_00000075

    authors: Nojiri K,Sugimoto K,Shiraki K,Kusagawa S,Tanaka J,Beppu T,Yamamoto N,Takei Y,Hashimoto A,Shimizu A,Omori S,Tameda M,Takase K

    更新日期:2010-05-01 00:00:00

  • Conversion to monotherapy with luteinizing-hormone releasing hormone agonist or orchiectomy after reaching PSA nadir following maximal androgen blockade is able to prolong progression-free survival in patients with metastatic prostate cancer: A propensity

    abstract::The present study evaluated androgen deprivation methods to determine the approach that most improves the progression-free survival (PFS) of patients with metastatic prostate cancer. Patients had received continuous maximal androgen blockade (MAB) or monotherapy [luteinizing-hormone releasing hormone (LHRH) agonist or...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6056

    authors: Min GE,Ahn H

    更新日期:2017-06-01 00:00:00

  • Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro.

    abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.644

    authors: Tong N,Zhang J,Chen Y,Li Z,Luo Y,Zuo H,Zhao X

    更新日期:2012-06-01 00:00:00

  • Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.

    abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9322

    authors: Zhang F,Zhu Y,Fan G,Hu S

    更新日期:2018-10-01 00:00:00

  • Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells.

    abstract::Andrographolide (Andro), a natural compound isolated from Andrographis paniculata, has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7941

    authors: Liu G,Chu H

    更新日期:2018-04-01 00:00:00

  • SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.

    abstract::Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in col...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7989

    authors: Liu W,Wu M,Du H,Shi X,Zhang T,Li J

    更新日期:2018-04-01 00:00:00

  • DMSO exhibits similar cytotoxicity effects to thalidomide in mouse breast cancer cells.

    abstract::The purpose of this study was to evaluate the cytotoxic effect of thalidomide on 4T1 and 4THMpc mouse breast cancer cell lines. Mouse breast cancer cells (4T1) and cells derived from metastatic lesions (4THMpc) were treated with various doses of thalidomide [10(-2)-100 µM dissolved in dimethyl sulfoxide (DMSO) as reco...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.559

    authors: Oz ES,Aydemir E,Fışkın K

    更新日期:2012-04-01 00:00:00

  • Clinical significance of chromatin remodeling factor CHD5 expression in gastric cancer.

    abstract::Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer. CHD5 expression was evaluated using immunohistochemis...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.11138

    authors: Hashimoto T,Kurokawa Y,Wada N,Takahashi T,Miyazaki Y,Tanaka K,Makino T,Yamasaki M,Nakajima K,Mori M,Doki Y

    更新日期:2020-01-01 00:00:00

  • Clinical value of magnetic resonance imaging in preoperative T staging of gastric cancer and postoperative pathological diagnosis.

    abstract::The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2135

    authors: Huo X,Yuan K,Shen Y,Li M,Wang Q,Xing L,Shi G

    更新日期:2014-07-01 00:00:00

  • Age is a prognostic factor affecting survival in lung cancer patients.

    abstract::Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1566

    authors: Tas F,Ciftci R,Kilic L,Karabulut S

    更新日期:2013-11-01 00:00:00