Semi-automated evaluation of Ki-67 index in invasive ductal carcinoma of the breast.

abstract：:MicroRNA (miRNA or miR)-298 has been reported to be downregulated and to modify the expression of the polycomb protein enhancer of zeste 2 (EZH2) in recurrent epithelial ovarian cancer (EOC). To date, no functional evidence of a miR-298-EZH2 axis in EOC has been documented. The present study aimed to investigate the a...

journal_title：Oncology letters

authors： Zhou F,Chen J,Wang H

更新日期：2016-11-01 00:00:00

abstract：:Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in col...

journal_title：Oncology letters

authors： Liu W,Wu M,Du H,Shi X,Zhang T,Li J

更新日期：2018-04-01 00:00:00

abstract：:Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle ...

journal_title：Oncology letters

authors： Nakamura Y,Ishigaki Y

更新日期：2014-12-01 00:00:00

abstract：:Peritumoral edema (PTE), one of the main characteristics of malignant glioma, is a significant contributor to the morbidity and mortality from glioma, however, a recent systematic review suggested that controversy remains with regard to its prognostic value. To further determine whether PTE was a potential prognostic ...

journal_title：Oncology letters

authors： Wu CX,Lin GS,Lin ZX,Zhang JD,Chen L,Liu SY,Tang WL,Qiu XX,Zhou CF

更新日期：2015-11-01 00:00:00

abstract：:The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...

journal_title：Oncology letters

authors： Liu P,Yao Q,Li NA,Liu Y,Wang Y,Li M,Li Z,Li J,Li G

更新日期：2016-05-01 00:00:00

abstract：:Heterogeneous radiological responses (HRRs) among tumor lesions are usually observed following chemotherapy or radiation treatment in cancer patients. When HRR is observed after chemotherapy or radiation treatment, a change in anticancer treatment is recommended due to the clinically high suspicion of resistance in th...

journal_title：Oncology letters

authors： Ryu JS,Kim L,Kim WC,Kim JS,Memon A,Yi BR,Kim HJ

更新日期：2015-11-01 00:00:00

abstract：:SIRT6, is a member of the NAD-dependent sirtuin family of enzymes, and has been reported as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However, the role of SIRT6 in osteosarcoma has not been investigated. The present study demonstrated that the expression of SIRT6 was downregulated in ...

journal_title：Oncology letters

authors： Gao Y,Qu Y,Zhou Q,Ma Y

更新日期：2019-01-01 00:00:00

abstract：:Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...

journal_title：Oncology letters

authors： Fu C,Wang L,Tian G,Zhang C,Zhao Y,Xu H,Su M,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated to be involved in epigenetic r...

journal_title：Oncology letters

authors： Litwin M,Szczepańska-Buda A,Piotrowska A,Dzięgiel P,Witkiewicz W

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...

journal_title：Oncology letters

authors： Al-Muhtaseb SI

更新日期：2014-12-01 00:00:00

abstract：:Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...

journal_title：Oncology letters

authors： Al-Qasem A,Toulimat M,Tulbah A,Elkum N,Al-Tweigeri T,Aboussekhra A

更新日期：2012-04-01 00:00:00

abstract：:With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes...

journal_title：Oncology letters

authors： Jeon YH,Ha M,Kim SW,Kim MJ,Lee CS,Oh CK,Han ME,Oh SO,Kim YH

更新日期：2019-05-01 00:00:00

abstract：:The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...

journal_title：Oncology letters

authors： Ogose A,Hotta T,Shibata M,Kawashima H,Endo N

更新日期：2010-01-01 00:00:00

abstract：:LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...

journal_title：Oncology letters

authors： Zhang F,Qin S,Xiao X,Tan Y,Hao P,Xu Y

更新日期：2019-08-01 00:00:00

abstract：:Clinical application value was investigated of transvaginal color Doppler ultrasound (TV-CDS) combined with serum tumor markers carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF) and osteopontin (OPN) in the diagnosis of ovarian cancer (OC). One hundred and six patients with OC [malignant tumo...

journal_title：Oncology letters

authors： Yu C,Dou T,Liu Y,Liu R

更新日期：2020-08-01 00:00:00

abstract：:The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

journal_title：Oncology letters

authors： Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

更新日期：2016-07-01 00:00:00

abstract：:Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated...

journal_title：Oncology letters

authors： Wu Y,Zhu Y,Li S,Zeng M,Chu J,Hu P,Li J,Guo Q,Lv XB,Huang G

更新日期：2017-04-01 00:00:00

abstract：:The clinical resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been linked to EGFR T790M resistance mutations or MET amplifications. Additional mechanisms underlying EGFR-TKI drug resistance remain unclear. The present study demonstrated t...

journal_title：Oncology letters

authors： Zhai Y,Zhang Y,Nan K,Liang X

更新日期：2017-05-01 00:00:00

abstract：:There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (U...

journal_title：Oncology letters

authors： Hartmann S,Brisam M,Rauthe S,Driemel O,Brands RC,Rosenwald A,Kübler AC,Müller-Richter UD

更新日期：2016-10-01 00:00:00

abstract：:ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...

journal_title：Oncology letters

authors： Liu X,Li G,Ai L,Ye Q,Yu T,Yang B

更新日期：2019-08-01 00:00:00

abstract：:Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...

journal_title：Oncology letters

authors： Wang B,Li J,Li X,Ou Y

更新日期：2019-10-01 00:00:00

abstract：:The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...

journal_title：Oncology letters

authors： Zheng Y,Li YF,Wang W,Chen YM,Wang DD,Zhao JJ,Pan QZ,Jiang SS,Zhang XF,Yuan SQ,Qiu HB,Huang CY,Zhao BW,Zhou ZW,Xia JC

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have revealed the aberrant expression of a number of microRNAs (miRNA/miRs) in the blood circulation of patients with breast cancer (BC). The aim of the present study was to assess the effect of neoadjuvant chemotherapy on the levels of a panel of BC-associated miRNAs, which are at relatively low (let...

journal_title：Oncology letters

authors： Gezer U,Keskin S,Iğci A,Tükenmez M,Tiryakioğlu D,Cetinkaya M,Dişci R,Dalay N,Eralp Y

更新日期：2014-08-01 00:00:00

abstract：:The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18F-FDG PE...

journal_title：Oncology letters

authors： Jiang L,Huang Y,Tang Q,Zhao Q,Li Y,Wu X,Wang H

更新日期：2018-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...

journal_title：Oncology letters

authors： Kim JB,Lee S,Kim HR,Park SY,Lee M,Yoon JH,Kim YJ

更新日期：2018-06-01 00:00:00

abstract：:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...

journal_title：Oncology letters

authors： Wan S,Zhao H

更新日期：2020-11-01 00:00:00

abstract：:Urothelial carcinoma (UC) is the most common type of cancer of the bladder and upper urinary tract, and is characterized by a high risk of recurrence and progression. Urine fluorescence in situ hybridization (FISH) is a technique that detects genetic aberrations in exfoliated cells in the urine, with specific probes f...

journal_title：Oncology letters

authors： Lin T,Liu Z,Liu L,Yang L,Han P,Zhang P,Wei Q

更新日期：2017-05-01 00:00:00

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...

journal_title：Oncology letters

authors： Nakashoji A,Matsui A,Nagayama A,Iwata Y,Sasahara M,Murata Y

更新日期：2017-10-01 00:00:00

abstract：:Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human e...

journal_title：Oncology letters

authors： Teng C,Li LI,Shen W,Li J,Liu Y,Jiang Q,Xin T,Huang D,Song X,Lv Y,Jin Y

更新日期：2015-08-01 00:00:00