Overexpression of carbohydrate sulfotransferase 15 in pancreatic cancer stroma is associated with worse prognosis.

abstract：:The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...

journal_title：Oncology letters

authors： Yang J,Ma JP,Xiao S,Zhang XH,Xu JB,Chen CQ,Cai SR,He YL

更新日期：2018-05-01 00:00:00

abstract：:Nucleobindin 2 (NUCB-2) is a multifunctional protein that contains several functional domains and is associated with a wide variety of biological processes, such as food intake and energy homeostasis. NUCB-2 has been demonstrated to be associated with worse malignant outcomes and cell migration in breast and prostate ...

journal_title：Oncology letters

authors： Tao R,Niu WB,Dou PH,Ni SB,Yu YP,Cai LC,Wang XY,Li SY,Zhang C,Luo ZG

更新日期：2020-06-01 00:00:00

abstract：:Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the featur...

journal_title：Oncology letters

authors： Hori T,Yasuda T,Suzuki K,Kanamori M,Kimura T

更新日期：2012-05-01 00:00:00

abstract：:Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...

journal_title：Oncology letters

authors： Liu F,Pan Z,Zhang J,Ni J,Wang C,Wang Z,Gu F,Dong W,Zhou W,Liu H

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...

journal_title：Oncology letters

authors： Al-Muhtaseb SI

更新日期：2014-12-01 00:00:00

abstract：:Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its unde...

journal_title：Oncology letters

authors： Feng D,Liu M,Liu Y,Zhao X,Sun H,Zheng X,Zhu J,Shang F

更新日期：2020-10-01 00:00:00

abstract：:Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...

journal_title：Oncology letters

authors： Qin J,Li Q,Zeng Z,Wu P,Jiang Y,Luo T,Ji X,Zhang Q,Hao Y,Chen L

更新日期：2018-06-01 00:00:00

abstract：:The present study reports a case of hemorrhage from branches of the right obturator artery following laparoscopic radical prostatectomy. On post-operative day 9, the patient complained of lower abdominal pain, and the hemoglobin and hematocrit levels had decreased. Emergency computed tomography angiography showed a la...

journal_title：Oncology letters

authors： Hiroshige T,Matsuo M,Ueda K,Nakiri M,Nishihara K,Igawa T

更新日期：2015-09-01 00:00:00

abstract：:The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and prolife...

journal_title：Oncology letters

authors： Han L,Jiang Y,Han D,Tan W

更新日期：2018-10-01 00:00:00

abstract：:The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...

journal_title：Oncology letters

authors： Wei ZT,Yu XW,He JX,Liu Y,Zhang SL

更新日期：2017-09-01 00:00:00

abstract：:Choroidal melanoma is the most common primary intraocular tumor in adults. Cepharanthine (CEP), a natural alkaloid extracted from the roots of Stephania cepharantha Hayata, has been demonstrated to inhibit the proliferation of various cancer cells. However, its potential anticancer effect in choroidal melanoma has not...

journal_title：Oncology letters

authors： Zhu Q,Guo B,Chen L,Ji Q,Liang H,Wen N,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative com...

journal_title：Oncology letters

authors： Yoon KB,Cho SY,An SJ,Park KR,Lee HJ,Yoon HS,Lee SM,Kim YC,Han SY

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...

journal_title：Oncology letters

authors： Wang N,Bu Q,Liu Q,Yang J,He H,Liu J,Ren X,Lyu J

更新日期：2019-08-01 00:00:00

abstract：:Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases ar...

journal_title：Oncology letters

authors： Panelli Santos KCP,Matsuzaki H,Unetsubo T,Tsuyoshi S,Nagatsuka H,Asaumi JI

更新日期：2017-04-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:The present study describes the case of a 48-year-old man who was diagnosed with lung adenocarcinoma with an epidermal growth factor receptor (EGFR) 21 L858R mutation. The patient received surgery and adjuvant chemotherapy. When multiple lung metastases appeared, icotinib was administered. Following resistance to icot...

journal_title：Oncology letters

authors： Lu H,Chen B,Qin J,Xie F,Han N,Huang Z

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...

journal_title：Oncology letters

authors： Ichinokawa K,Nakanishi Y,Hida Y,Tsuchikawa T,Kato T,Itoh T,Kaji M,Kaga K,Hirano S

更新日期：2019-07-01 00:00:00

abstract：:erbB-2 is amplified or overexpressed in approximately 30% of human breast cancers, and has been associated with poor prognosis and therapeutic resistance. Previous studies have suggested that erbB-2 overexpression in transgenic mice induces genomic instability; however, the patterns of genetic lesions vary with indivi...

journal_title：Oncology letters

authors： Kim YM,Ma Z,Lee S,Lee J,Li S,Yang X

更新日期：2011-11-01 00:00:00

abstract：:Penile cancer is an extremely rare form of urological cancer that usually originates in the epithelium of the inner preputium or glans. Major etiological factors include phimosis, poor penile hygiene and smoking. Nearly 95% of penile cancers are squamous cell carcinomas and usually occur in the sixth decade of life. T...

journal_title：Oncology letters

authors： Öztürk H

更新日期：2015-03-01 00:00:00

abstract：:This study investigated the effects of hyperoside on apoptosis of human thyroid squamous cell carcinoma cells (SW579) and measured changes in the expression of known apoptosis regulatory players Fas/FasL and survivin. SW579 cells were treated with increasing concentrations of hyperoside. The cell proliferation inhibit...

journal_title：Oncology letters

authors： Liu Z,Liu G,Liu X,Li S

更新日期：2017-08-01 00:00:00

abstract：:In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...

journal_title：Oncology letters

authors： Zhang J,Ou Y,Ma Y,Zheng L,Zhang X,Xia R,Kong F,Shen Y,Wang S,Lin L

更新日期：2015-04-01 00:00:00

abstract：:Approximately 34-86% of neoplasms of the salivary glands are located in the parotid gland and parotidectomy is the first-line treatment for parotid gland tumors. Frey syndrome and cosmetic deformity are common complications experienced by patients following parotidectomy and the sternocleidomastoid muscle flap (SCMF) ...

journal_title：Oncology letters

authors： Liu DY,Tian XJ,Li C,Sun SS,Xiong YH,Zeng XT

更新日期：2013-04-01 00:00:00

abstract：:microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

journal_title：Oncology letters

authors： Li L,Jia L,Ding Y

更新日期：2018-09-01 00:00:00

abstract：:In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

journal_title：Oncology letters

authors： Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

更新日期：2013-08-01 00:00:00

abstract：:Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...

journal_title：Oncology letters

authors： Lin M,Li Y,Qin S,Jiao Y,Hua F

更新日期：2020-04-01 00:00:00

abstract：:The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....

journal_title：Oncology letters

authors： Wei S,Yun X,Ruan X,Wei X,Zheng X,Gao M

更新日期：2019-12-01 00:00:00

abstract：:Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce imm...

journal_title：Oncology letters

authors： Song D,Li H,Li H,Dai J

更新日期：2015-08-01 00:00:00

abstract：:Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...

journal_title：Oncology letters

authors： Wu YL,Zhou L,Lu Y

更新日期：2016-08-01 00:00:00

abstract：:The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III...

journal_title：Oncology letters

authors： Cai Y,Zheng M,Zhao Z,Huang H,Fu W,Xu X

更新日期：2017-09-01 00:00:00