Evaluating the prognostic value and functional roles of transcription factor AP4 in colorectal cancer.

abstract：:Gastric cancer (GC) is one of the most common malignancies and is the second leading cause of cancer-associated mortality world-wide. In the present study, the prognostic value and antitumor effects of transforming growth factor β1 (TGFβ1) and its receptors in GC were explored. The online Kaplan-Meier plotter database...

journal_title：Oncology letters

authors： Liu F,Wang H,Zhang M

更新日期：2020-09-01 00:00:00

abstract：:The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...

journal_title：Oncology letters

authors： He S,Fan X,Ma H,Xiaerfuhazi H,Rehato A,Feng J,Shi X,He F

更新日期：2019-08-01 00:00:00

abstract：:The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...

journal_title：Oncology letters

authors： Ren HP,Yin XY,Yu HY,Xiao HF

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to analyze potential therapy targets for prostate cancer using integrated analysis of two gene expression profiles. First, gene expression profiles GSE38241 and GSE3933 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between prostate can...

journal_title：Oncology letters

authors： Zhao R,Wang Y,Zhang M,Gu X,Wang W,Tan J,Wei X,Jin N

更新日期：2017-11-01 00:00:00

abstract：:As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...

journal_title：Oncology letters

authors： Zou Y,Yang J,Wu J,Luo C,Huang Y

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...

journal_title：Oncology letters

authors： Sun W,Li C,Liu M,Liu W,Yang C,Cai LI

更新日期：2016-03-01 00:00:00

abstract：:Bone metastasis resulting from breast cancer in pregnancy is rare. In the literature there are few reports regarding osteolytic lesions in pregnancy and no data on the treatment of such femoral fractures. The present study reports a case of a 29-week primigravida presenting with severe lumbosciatica in the left side, ...

journal_title：Oncology letters

authors： Ciavattini A,Mancioli F,Paci E,Politano R

更新日期：2016-01-01 00:00:00

abstract：:The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory exa...

journal_title：Oncology letters

authors： Zhang Z,Zou J,Li Y,Liu Z,Xu R,Tian W,Zhao Z,Sun H,Han J,Wang J,Zhang B,Ju Y

更新日期：2015-05-01 00:00:00

abstract：:Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer. CHD5 expression was evaluated using immunohistochemis...

journal_title：Oncology letters

authors： Hashimoto T,Kurokawa Y,Wada N,Takahashi T,Miyazaki Y,Tanaka K,Makino T,Yamasaki M,Nakajima K,Mori M,Doki Y

更新日期：2020-01-01 00:00:00

abstract：:The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...

journal_title：Oncology letters

authors： Chen S,Wang Y,Ruan W,Wang X,Pan C

更新日期：2014-11-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation and has been associated with numerous high-risk cancers. Previously, our group and others identified LSD1 as an upregulated gene in ovarian cancer, and reported that the upregulation of LSD1 was associated...

journal_title：Oncology letters

authors： Shao G,Wan X,Lai W,Wu C,Jin J,Liu X,Wei Y,Lin Q,Zhang L,Shao Q

更新日期：2018-06-01 00:00:00

abstract：:Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...

journal_title：Oncology letters

authors： Jin S,Xu C,Wang L,Wei J,Wang S

更新日期：2021-02-01 00:00:00

abstract：:Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its unde...

journal_title：Oncology letters

authors： Feng D,Liu M,Liu Y,Zhao X,Sun H,Zheng X,Zhu J,Shang F

更新日期：2020-10-01 00:00:00

abstract：:Gliomas are the most common primary tumors in adult central nervous system and result in disappointing survival outcomes. FOXL1, as a transcription factor, plays an important role in regulating the expression of genes involved in cell metabolism, proliferation and differentiation. In this study, we investigated the re...

journal_title：Oncology letters

authors： Chen A,Zhong L,Lv J

更新日期：2019-07-01 00:00:00

abstract：:Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it unsuitable for operative surgery, and resistant to chemotherapy and radiation therapy. Isochorismatase domain-containing protein 1 (ISOC1) has putative isochorismatase act...

journal_title：Oncology letters

authors： Cheng L,Zhao Y,Tang M,Luo Z,Wang X

更新日期：2019-05-01 00:00:00

abstract：:The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...

journal_title：Oncology letters

authors： Nakajima S,Morii K,Takahashi H,Fujii Y,Yamanaka R

更新日期：2016-03-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00

abstract：:Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T...

journal_title：Oncology letters

authors： Hachiman M,Yoshimitsu M,Ezinne C,Kuroki A,Kozako T,Arima N

更新日期：2018-07-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer-associated mortality in females in the USA. Hsa-miR-599 was demonstrated to function as a tumour suppressor during cancer progression. However, the function and mechanism of the hsa-miR-599 in human breast cancer remain elusive. Thus, the aim of the present study was...

journal_title：Oncology letters

authors： Wang Y,Sui Y,Zhu Q,Sui X

更新日期：2017-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally considered one of the most common gastrointestinal malignant tumors, characterized by high invasiveness and metastatic rate, as well as insidious onset. A relationship between carcinogenicity and aberrant microRNA-139-5p (miR-139-5p) expression has been identified in multipl...

journal_title：Oncology letters

authors： Qin H,Wen DY,Que Q,Zhou CY,Wang XD,Peng YT,He Y,Yang H,Liao BM

更新日期：2019-12-01 00:00:00

abstract：:Death associated protein kinase 1 (DAPK1) is a notable serine/threonine kinase involved in the regulation of multiple cellular pathways, including apoptosis and autophagy. Although DAPK1 is usually considered to be a tumor suppressor, it was previously reported to promote the viability of p53 mutant cancer cell lines ...

journal_title：Oncology letters

authors： Huang Y,Lin M,Chen X,Huang C,Zhang X,Chen L,Wu K,Chen Y,Zhu Y,Lin Y

更新日期：2018-06-01 00:00:00

abstract：:Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...

journal_title：Oncology letters

authors： Takesue T,Kawakubo H,Hayashida T,Tsutsui M,Miyao K,Fukuda K,Nakamura R,Takahashi T,Wada N,Takeuchi H,Kitagawa Y

更新日期：2017-10-01 00:00:00

abstract：:The molecule DRO1 (down‑regulated by oncogenes 1) is a potential tumor suppressor protein that is frequently down‑regulated in primary colorectal cancers and colorectal cancer cell lines. Although the mechanism of DRO1 action has yet to be elucidated, previous data have suggested that DRO1 interferes with tumor growth...

journal_title：Oncology letters

authors： Herbst A,Bayer C,Wypior C,Kolligs FT

更新日期：2011-09-01 00:00:00

abstract：:The detection of epidermal growth factor receptor (EGFR) mutations is necessary for the selection of suitable patients with non-small cell lung cancer (NSCLC) for treatment with EGFR tyrosine kinase inhibitors. Cytology specimens are known to be suitable for EGFR mutation detection, although tissue specimens should be...

journal_title：Oncology letters

authors： Asaka S,Yoshizawa A,Nakata R,Negishi T,Yamamoto H,Shiina T,Shigeto S,Matsuda K,Kobayashi Y,Honda T

更新日期：2018-02-01 00:00:00

abstract：:MicroRNA (miR)-125a-3p is derived from the 3'-end of pre-miR-125a, which is associated with several types of cancer, such as gastric and prostate cancer, and glioma. The aim of the present study was to identify the prognostic significance of miR-125a-3p expression levels in patients with NSCLC. The gene expression omn...

journal_title：Oncology letters

authors： Hou L,Luo P,Ma Y,Jia C,Yu F,Lv Z,Wu C,Fu D

更新日期：2017-10-01 00:00:00

abstract：:Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non...

journal_title：Oncology letters

authors： Liu S,Yang Y,Chen L,Liu D,Dong H

更新日期：2018-06-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is an abundant non-histone nuclear protein that functions as a structural protein of chromatin, regulating genome replication and recombination, mRNA transcription and DNA repair. HMGB1 has been implicated in the tumorigenesis of various cancer types, and the upregulation of HMGB1 has...

journal_title：Oncology letters

authors： Jia L,Song H,Fan W,Song Y,Wang G,Li X,He Y,Yao A

更新日期：2020-01-01 00:00:00

abstract：:Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation ass...

journal_title：Oncology letters

authors： Lee YH,Yang HW,Yang LC,Lu MY,Tsai LL,Yang SF,Huang YF,Chou MY,Yu CC,Hu FW

更新日期：2017-07-01 00:00:00

abstract：:The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as signi...

journal_title：Oncology letters

authors： Yu X,Li Z

更新日期：2015-10-01 00:00:00