Non-pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial.

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non-small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was t...

journal_title：Oncology letters

authors： Hao L,Du B,Xi X

更新日期：2017-08-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...

journal_title：Oncology letters

authors： Zhang F,Zhu Y,Fan G,Hu S

更新日期：2018-10-01 00:00:00

abstract：:Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...

journal_title：Oncology letters

authors： Chen Q,Zhou Z,Shan L,Zeng H,Hua Y,Cai Z

更新日期：2015-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT. EMT occurred i...

journal_title：Oncology letters

authors： He X,Qian Y,Cai H,Yang S,Cai J,Wang Z

更新日期：2015-08-01 00:00:00

abstract：:Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic ...

journal_title：Oncology letters

authors： Girgis EH,Mahoney JP,Khalil RH,Soliman MR

更新日期：2010-07-01 00:00:00

abstract：:Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...

journal_title：Oncology letters

authors： Zhang X,Fu Z,Gong G,Wei H,Duan J,Chen Z,Chen X,Wang R,Yin Y

更新日期：2017-09-01 00:00:00

abstract：:The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...

journal_title：Oncology letters

authors： Loilome W,Kadsanit S,Muisook K,Yongvanit P,Namwat N,Techasen A,Puapairoj A,Khuntikeo N,Phonjit P

更新日期：2017-02-01 00:00:00

abstract：:Small supernumerary maker chromosome (sSMC) is a type of structurally abnormal chromosome. In order to identify the origin, morphology and other characteristics of sSMCs in children with mos 45,X/46,X,+mar karyotype, 17 patients (16 females and 1 male) were analyzed. All patients underwent general physical examination...

journal_title：Oncology letters

authors： Wang H,Wang T,Yang N,He Y,Chen L,Hong L,Shao X,Li H,Zhu H,Li H

更新日期：2017-06-01 00:00:00

abstract：:Although there is evidence that galectin-9 is a critical factor in health and disease, the upstream regulatory microRNA (miRNA or miR) of the protein remains poorly defined. miR-455-5p is characterized as a tumor-associated miRNA in cancer research. However, the actual role of miR-455-5p with respect to inhibiting or ...

journal_title：Oncology letters

authors： Yang Q,Hou C,Huang D,Zhuang C,Jiang W,Geng Z,Wang X,Hu L

更新日期：2017-03-01 00:00:00

abstract：:The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...

journal_title：Oncology letters

authors： Li J,Xie Y,Wang X,Jiang C,Yuan X,Zhang A,Yang L,Liu C,Zou H,Li F,Hu J

更新日期：2020-11-01 00:00:00

abstract：:Protein tyrosine phosphatase receptor type A (PTPRA), one of the classic protein tyrosine phosphatases, is crucial for modulating tumorigenesis and metastasis in breast cancer; however, its functional mechanism has not fully elucidated. The present study assessed PTPRA expression and estimated its clinical impact on s...

journal_title：Oncology letters

authors： Lin C,Xin S,Huang X,Zhang F

更新日期：2020-11-01 00:00:00

abstract：:Invasive breast carcinoma (BRCA) is a serious disease that threatens the survival time of those affected. Alternative splicing (AS) involved in BRCA pathogenesis may be a potential therapeutic target. However, to the best of our knowledge, a systematic analysis of survival-related alternative splicing events (SREs) ha...

journal_title：Oncology letters

authors： Jia K,Wu Y,Huang J,Chen J,Wei H,Wu H

更新日期：2020-08-01 00:00:00

abstract：:Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylase...

journal_title：Oncology letters

authors： Shi Y,He R,Yang Y,He Y,Zhan L,Wei B

更新日期：2020-11-01 00:00:00

abstract：:Ovarian metastasis from non-small cell lung cancer (NSCLC) is a rare condition. The current study presents the cases of 2 female patients aged 38 and 47 years old, respectively, who were initially diagnosed with NSCLC adenocarcinoma on histology. Both patients initially presented with chest pain and a cough, and subse...

journal_title：Oncology letters

authors： Mushi RT,Yang Y,Cai Q,Zhang R,Wu G,Dong X

更新日期：2016-12-01 00:00:00

abstract：:Several previous studies have shown that mutations in B-Raf proto-oncogene (BRAF) and telomerase reverse transcriptase (TERT) can be used for the diagnosis and prognosis of papillary thyroid carcinoma (PTC). However, whether mutations in BRAF and the TERT promoter may improve the accurate identification and risk strat...

journal_title：Oncology letters

authors： Liu R,Li Y,Chen W,Cong J,Zhang Z,Ma L,Chu L,Xiao H,Zhang Y,Liu Y,Xu Y,Yu Q,Yang X,Sun C

更新日期：2020-10-01 00:00:00

abstract：:Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment. Chemokines are an important factor affecting the tumor immune microenvironme...

journal_title：Oncology letters

authors： Wu B,Wang J,Wang X,Zhu M,Chen F,Shen Y,Zhong Z

更新日期：2020-11-01 00:00:00

abstract：:Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated resto...

journal_title：Oncology letters

authors： Terzidou C,Trivli A,Dalianis G,Apessou D,Spandidos DA,Goulielmos GN

更新日期：2018-07-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowle...

journal_title：Oncology letters

authors： Wei YB,Gao YL,Wu HT,Ou-Yang SF,Xu T,Mao DF,Yang JR

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive...

journal_title：Oncology letters

authors： Ohara G,Miyazaki K,Kurishima K,Kagohashi K,Ishikawa H,Satoh H,Hizawa N

更新日期：2012-02-01 00:00:00

abstract：:Solitary fibrous tumors (SFTs) are uncommon, with the pleura as a site of predilection. Central nervous system SFTs, particularly intracranial SFTs, are extremely rare. The lesions are generally benign and localized, and surgery is the main therapeutic solution. The current study reports the cases of a patient who pre...

journal_title：Oncology letters

authors： Wang ZY,Qiu K,Ma YH,Wang XT,Bao JJ,Zhang ZF,Liu XZ

更新日期：2016-02-01 00:00:00

abstract：:Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...

journal_title：Oncology letters

authors： Iwahashi N,Sakai K,Noguchi T,Yahata T,Toujima S,Nishio K,Ino K

更新日期：2018-11-01 00:00:00

abstract：:Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...

journal_title：Oncology letters

authors： Zhou J,Teng R,Wang Q,Xu C,Guo J,Yuan C,Shen J,Hu W,Wang L,Xie S

更新日期：2013-08-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:Human four-and-a-half LIM domains protein 1 (FHL1) is a member of the FHL protein family, which serves an important role in multiple cellular events by interacting with transcription factors using its cysteine-rich zinc finger motifs. A previous study indicated that FHL1 was downregulated in several types of human can...

journal_title：Oncology letters

authors： Li SZ,Hu YY,Zhao JL,Zang J,Fei Z,Han H,Qin HY

更新日期：2020-06-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common form of bone malignancy in children and adolescents. A class of molecules known as microRNAs (miRNAs) have been routinely associated in the development and progression of OS. The present study was centered on the less well-known miRNA, miRNA (miR)-150, and its role in OS was invest...

journal_title：Oncology letters

authors： Li CH,Yu TB,Qiu HW,Zhao X,Zhou CL,Qi C

更新日期：2017-04-01 00:00:00

abstract：:It has been demonstrated that microRNA-497 (miR-497) acts as a tumor suppressor and is involved in tumor progression, development and metastasis in several types of cancer. However, little is known about the exact role of miR-497 in osteosarcoma (OS). The aim of the current study was to investigate the potential role ...

journal_title：Oncology letters

authors： Ge L,Zheng B,Li M,Niu L,Li Z

更新日期：2016-03-01 00:00:00

abstract：:The present study examined the association between squamous cell carcinoma antigen (SCCA) expression and the response of patients with cervical cancer to docetaxel-carboplatin (DC) combination chemotherapy, in order to determine the prognostic potential of SCCA expression. A total of 21 patients were enrolled with sta...

journal_title：Oncology letters

authors： Chen P,Jiao L,Wang DB

更新日期：2017-03-01 00:00:00

abstract：:Gliomas are the most common primary tumors in adult central nervous system and result in disappointing survival outcomes. FOXL1, as a transcription factor, plays an important role in regulating the expression of genes involved in cell metabolism, proliferation and differentiation. In this study, we investigated the re...

journal_title：Oncology letters

authors： Chen A,Zhong L,Lv J

更新日期：2019-07-01 00:00:00

abstract：:Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. In the present study, TFC was found to potent...

journal_title：Oncology letters

authors： Sheng Y,Zou M,Wang Y,Li Q

更新日期：2015-12-01 00:00:00

abstract：:A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...

journal_title：Oncology letters

authors： Mantas D,Kostakis ID,Machairas N,Markopoulos C

更新日期：2016-08-01 00:00:00