Abstract:
:Human four-and-a-half LIM domains protein 1 (FHL1) is a member of the FHL protein family, which serves an important role in multiple cellular events by interacting with transcription factors using its cysteine-rich zinc finger motifs. A previous study indicated that FHL1 was downregulated in several types of human cancer and served a role as a tumor suppressive gene. The overexpression of FHL1 inhibited tumor cell proliferation. However, to the best of our knowledge, there is no evidence to confirm whether FHL1 affected glioma growth, and the molecular mechanisms through which FHL1 represses tumor development remain unclear. In the present study, the expression level of FHL1 was determined using immunohistochemical staining in 114 tumor specimens from patients with glioma. The results indicated that FHL1 expression was negatively associated with the pathological grade of gliomas. Furthermore, Kaplan-Meier survival curves demonstrated that the patients with an increased FHL1 expression exhibited a significantly longer survival time, suggesting that FHL1 may be a prognostic marker for glioma. The protein level of FHL1 was relatively increased in the U251 glioma cell line compared with that in the U87 cell line. Therefore, FHL1 was knocked down in U251 by siRNA and overexpressed in U87, and it was identified that FHL1 significantly decreased the activation of PI3K/AKT signaling by interacting with AKT. Further experiments verified that FHL1 inhibited the growth of gliomas in vivo by modulating PI3K/AKT signaling. In conclusion, the results of the present study demonstrated that FHL1 suppressed glioma development through PI3K/AKT signaling.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Li SZ,Hu YY,Zhao JL,Zang J,Fei Z,Han H,Qin HYdoi
10.3892/ol.2020.11476subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3781-3788issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-11476journal_volume
19pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::[This corrects the article DOI: 10.3892/ol.2019.10030.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11409
更新日期:2020-04-01 00:00:00
abstract::The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8836
更新日期:2018-08-01 00:00:00
abstract::Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10200
更新日期:2019-06-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as a global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the role of SATB1 in gastric cancer, especially in regulating the malignant phenotypes, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.681
更新日期:2012-07-01 00:00:00
abstract::Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7329
更新日期:2018-01-01 00:00:00
abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4146
更新日期:2016-03-01 00:00:00
abstract::5,7-dihydroxy-3',4',6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3563
更新日期:2015-10-01 00:00:00
abstract::The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11308
更新日期:2020-03-01 00:00:00
abstract::Lung cancer is the most common cause of cancer-related mortality in men and women. Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, >50% of patients are >65 years old. Through an improved understanding of the molecular mechanisms involved in lung oncogenesis, molecular-ta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3901
更新日期:2016-01-01 00:00:00
abstract::Percutaneous transluminal angioplasty using balloon catheters for Budd-Chiari syndrome (BCS) and transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (HCC) have become increasingly accepted as alternative therapeutic modalities. However, few studies have investigated the clinical e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1417
更新日期:2013-08-01 00:00:00
abstract::The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.814
更新日期:2012-10-01 00:00:00
abstract::The present study aimed to explore the expression of microRNA (miRNA or miR) in drug-resistant and drug-sensitive ovarian cancer cell lines, and to seek the potential therapeutic target of ovarian cancer drug-resistant mechanism in order to improve drug resistance by altering miRNA levels. The drug-resistant character...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4831
更新日期:2016-09-01 00:00:00
abstract::The present study aims to quantitatively measure adiposity-related image features and to test the feasibility of applying multivariate statistical data analysis-based prediction models to generate a novel clinical marker and predict the benefit of epithelial ovarian cancer (EOC) patients with and without maintenance b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4648
更新日期:2016-07-01 00:00:00
abstract::The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5744
更新日期:2017-04-01 00:00:00
abstract::In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1660
更新日期:2014-01-01 00:00:00
abstract::Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11071
更新日期:2020-01-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is rare in the adult population and even rarer with jaw involvement. The current study presents the case of a 39-year-old male who complained of recurrent pain, swelling of the gingiva and an occasional pus-like discharge in the right mandible for one year. The patient was previousl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2272
更新日期:2014-09-01 00:00:00
abstract::The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3607
更新日期:2015-10-01 00:00:00
abstract::Heterogeneous radiological responses (HRRs) among tumor lesions are usually observed following chemotherapy or radiation treatment in cancer patients. When HRR is observed after chemotherapy or radiation treatment, a change in anticancer treatment is recommended due to the clinically high suspicion of resistance in th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3709
更新日期:2015-11-01 00:00:00
abstract::Esophageal cancer is one of the most common types of malignant tumors located within the digestive system, with >50% of esophageal cancer cases worldwide occurring in China. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer; however, few lncRNAs have been charac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7968
更新日期:2018-04-01 00:00:00
abstract::Pleural effusion (PE) is a common manifestation associated with certain chest diseases. However, there is no effective diagnostic marker with high sensitivity and specificity. The aim of the present study was to evaluate the diagnostic performance of several biomarkers in the use of detecting malignant pleural disorde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8871
更新日期:2018-08-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowle...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2635
更新日期:2015-01-01 00:00:00
abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5785
更新日期:2017-04-01 00:00:00
abstract::Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11423
更新日期:2020-04-01 00:00:00
abstract::Cross-talk between competing endogenous RNAs (ceRNAs) play key roles in tumor development. In this study, we performed exon-level expression profiling on 26 glioblastomas (GBMs) and 6 controls to identify long non-coding RNAs (lncRNAs) of GBM initiation and progression using lncRNA-mediated ceRNA network (LMCN). The m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10114
更新日期:2019-05-01 00:00:00
abstract::Lung adenocarcinoma (LUAD) is a common malignancy; however, the majority of its underlying molecular mechanisms remain unknown. In the present study, weighted gene co-expression network analysis was applied to construct gene co-expression networks for the GSE19804 dataset, in order to screen hub genes associated with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11193
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to discuss the antitumor effect of Tegafur combined with Barbadian on S-180 tumor-bearing mice. A murine tumor model was prepared by subcutaneous injection of S-180 sarcoma cells to the armpit of the right limb of healthy female SPF KM mice. The 24 tumor-bearing mice were randomly divided int...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9373
更新日期:2018-11-01 00:00:00
abstract::Protein tyrosine phosphatase receptor type A (PTPRA), one of the classic protein tyrosine phosphatases, is crucial for modulating tumorigenesis and metastasis in breast cancer; however, its functional mechanism has not fully elucidated. The present study assessed PTPRA expression and estimated its clinical impact on s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11992
更新日期:2020-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5466
更新日期:2017-02-01 00:00:00