Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.


:Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its underlying anticancer mechanism remains to be understood. The present study aimed to investigate the effects of MCL on human glioma U251MG cells and to determine the potential anticancer mechanism of action of MCL. From Cell Counting Kit-8, colony formation assay, apoptosis assay and Confocal immunofluorescence imaging analysis, the results revealed that MCL significantly inhibited cell viability in vitro and induced cell apoptosis via activation of the cytochrome c/caspase-dependent apoptotic pathway. In addition, MCL also suppressed cell invasion and metastasis via the wound healing and Transwell invasion assays. Furthermore, western blot and reverse transcription PCR analyses demonstrated that MCL significantly downregulated cyclooxygenase-2 (COX-2) expression levels, which may have partially occurred through the inactivation of the NF-κB signaling pathway. In conclusion, the results of the present study indicated that MCL may inhibit glioma carcinoma growth by downregulating the NF-κB/COX-2 signaling pathway, which suggested that MCL may be a novel and alternative antitumor agent for the treatment of human glioma carcinoma.


Oncol Lett


Oncology letters


Feng D,Liu M,Liu Y,Zhao X,Sun H,Zheng X,Zhu J,Shang F




Has Abstract


2020-10-01 00:00:00














  • Human wings apart-like gene is specifically overexpressed in cervical cancer.

    abstract::Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Lu X,Cui J,Fu M,Wang W

    更新日期:2016-07-01 00:00:00

  • Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A.

    abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Dong Y,Li Y,Liu R,Li Y,Zhang H,Liu H,Chen J

    更新日期:2020-03-01 00:00:00

  • Homeobox B4 inhibits breast cancer cell migration by directly binding to StAR-related lipid transfer domain protein 13.

    abstract::The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhou G,Liu X,Xiong B,Sun Y

    更新日期:2017-10-01 00:00:00

  • miR-34a inhibits esophageal squamous cell carcinoma progression via regulation of FOXM1.

    abstract::Downregulation of microRNA-34a (miR-34a) has frequently been observed in esophageal squamous cell carcinoma (ESCC). However, the underlying role and molecular mechanism of miR-34a in ESCC remains largely unknown. In the current study, it was demonstrated that miR-34a was downregulated and forkhead box M1 (FOXM1), a ta...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhou H,Yang L,Xu X,Lu M,Guo R,Li D,Huang Q,Liu Y,Deng G,Xu Y

    更新日期:2019-01-01 00:00:00

  • High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma.

    abstract::The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao W,Xu H

    更新日期:2016-08-01 00:00:00

  • Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen.

    abstract::Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang X,Jiang Y,Yuan M,Chen C,Wang K,Zhang Q,Zuo Y,Ren S

    更新日期:2017-09-01 00:00:00

  • Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2.

    abstract::[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...

    journal_title:Oncology letters

    pub_type: 杂志文章,撤回出版物


    authors: Li L,Mao X,Qin X,Zhou M,Xing H,Dong F,Jiang X,Zhuang W

    更新日期:2019-05-01 00:00:00

  • Collecting duct carcinoma of the kidney: Imaging observations of a rare tumor.

    abstract::Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

    更新日期:2014-02-01 00:00:00

  • Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.

    abstract::The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao Z,Li C,Song Y,Wu Q,Qiao F,Fan H

    更新日期:2012-02-01 00:00:00

  • Overexpression of EPAC2 reduces the invasion of glioma cells via MMP-2.

    abstract::Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Jiang M,Zhuang Y,Zu WC,Jiao L,Richard SA,Zhang S

    更新日期:2019-06-01 00:00:00

  • Predictive value of inflammatory indexes on the chemotherapeutic response in patients with unresectable lung cancer: A retrospective study.

    abstract::Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Sun H,Hu P,Du J,Wang X

    更新日期:2018-03-01 00:00:00

  • Successful treatment of quintuple primary cancer, including esophageal cancer: A case report.

    abstract::The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Otowa Y,Nakamura T,Takiguchi G,Urakawa N,Ishida R,Imanishi T,Suzuki S,Tanaka K,Kuroda D,Kakeji Y

    更新日期:2015-06-01 00:00:00

  • lncRNAs are novel biomarkers for differentiating between cisplatin-resistant and cisplatin-sensitive ovarian cancer.

    abstract::Cisplatin-resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin-based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li Q,Zhang J,Zhou J,Yang B,Liu P,Cao L,Jing L,Liu H

    更新日期:2018-06-01 00:00:00

  • Expression of Toll-like receptor-9 is associated with poor progression-free survival in prostate cancer.

    abstract::Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

    更新日期:2013-05-01 00:00:00

  • Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma.

    abstract::The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

    更新日期:2017-03-01 00:00:00

  • Effect of targeted silencing of IL-8 on in vitro migration and invasion of SKOV3 ovarian cancer cells.

    abstract::The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li Y,Liu L,Yin Z,Xu H,Li S,Tao W,Cheng H,Du L,Zhou X,Zhang B

    更新日期:2017-02-01 00:00:00

  • Partial response of liver metastases treated with abiraterone in castration-resistant prostate cancer: A case report.

    abstract::Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Marech I,Vacca A,Sivestris N,Gnoni A,Lorusso V

    更新日期:2013-06-01 00:00:00

  • Cancer stem-like cells persist in established cell lines through autocrine activation of EGFR signaling.

    abstract::Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Kim J,Jung J,Lee SJ,Lee JS,Park MJ

    更新日期:2012-03-01 00:00:00

  • Cleistanthin A inhibits the invasion and metastasis of human melanoma cells by inhibiting the expression of matrix metallopeptidase-2 and -9.

    abstract::It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Pan S,Cai H,Gu L,Cao S

    更新日期:2017-11-01 00:00:00

  • Notable roles of EZH2 and DNMT1 in epigenetic dormancy of the SHP1 gene during the progression of chronic myeloid leukaemia.

    abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Wang J,Hua L,Guo M,Yang L,Liu X,Li Y,Shang X,Luo J

    更新日期:2017-06-01 00:00:00

  • Expression of GLUT1 is associated with increasing grade of malignancy in non-invasive and invasive urothelial carcinomas of the bladder.

    abstract::Glucose Transporter 1 (GLUT1) belongs to the expanding mammalian facilitative glucose transporter family. Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. Whereas malignant cells have an accelerated metabolism with inc...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Reis H,Tschirdewahn S,Szarvas T,Rübben H,Schmid KW,Grabellus F

    更新日期:2011-11-01 00:00:00

  • Endoscopic ultrasonography for pretreatment T-staging of gastric cancer: An in vitro accuracy and discrepancy analysis.

    abstract::In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Yan Y,Wu Q,Li ZY,Bu ZD,Ji JF

    更新日期:2019-03-01 00:00:00

  • Upregulation of miR-375 inhibits human liver cancer cell growth by modulating cell proliferation and apoptosis via targeting ErbB2.

    abstract::microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li L,Jia L,Ding Y

    更新日期:2018-09-01 00:00:00

  • Coexistence of adenomyosis uteri and endometrial cancer is associated with an improved prognosis compared with endometrial cancer only.

    abstract::The present study aimed to identify differences in protein expression in cases of endometrioid endometrial cancer (EEC) with and without coexisting adenomyosis uteri (AM), and to evaluate the histopathological and prognostic distinctions. The total cohort included 22 patients in Group A (patients with concomitant AM a...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Hertlein L,Rath J,Zeder-Göss C,Fürst S,Bayer D,Trillsch F,Mahner S,Burges A,Jeschke U

    更新日期:2017-09-01 00:00:00

  • Bcl-2/Bcl-xL inhibitor ABT-737 sensitizes pancreatic ductal adenocarcinoma to paclitaxel-induced cell death.

    abstract::Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Kasai S,Sasaki T,Watanabe A,Nishiya M,Yasuhira S,Shibazaki M,Maesawa C

    更新日期:2017-07-01 00:00:00

  • Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins.

    abstract::In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Xu XM,Zhang ML,Zhang Y,Zhao L

    更新日期:2016-11-01 00:00:00

  • Identification of candidate drugs for the treatment of metastatic osteosarcoma through a subpathway analysis method.

    abstract::Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Li X,Yan ML,Yu Q

    更新日期:2017-06-01 00:00:00

  • Limb salvage surgery following resection of a melanoma: Foot and ankle reconstruction using cutaneous flaps.

    abstract::Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Liu JF,Zhao LR,Lu LJ,Chen L,Liu ZG,Gong X,Liu B

    更新日期:2014-11-01 00:00:00

  • Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma.

    abstract::Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

    更新日期:2016-12-01 00:00:00

  • Interleukin-6 as a potential molecular target in esophageal squamous cell carcinoma.

    abstract::Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

    journal_title:Oncology letters

    pub_type: 杂志文章


    authors: Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

    更新日期:2016-02-01 00:00:00