Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...

journal_title：Oncology letters

authors： Dong Y,Li Y,Liu R,Li Y,Zhang H,Liu H,Chen J

更新日期：2020-03-01 00:00:00

abstract：:The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...

journal_title：Oncology letters

authors： Zhou G,Liu X,Xiong B,Sun Y

更新日期：2017-10-01 00:00:00

abstract：:Downregulation of microRNA-34a (miR-34a) has frequently been observed in esophageal squamous cell carcinoma (ESCC). However, the underlying role and molecular mechanism of miR-34a in ESCC remains largely unknown. In the current study, it was demonstrated that miR-34a was downregulated and forkhead box M1 (FOXM1), a ta...

journal_title：Oncology letters

authors： Zhou H,Yang L,Xu X,Lu M,Guo R,Li D,Huang Q,Liu Y,Deng G,Xu Y

更新日期：2019-01-01 00:00:00

abstract：:The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...

journal_title：Oncology letters

authors： Zhao W,Xu H

更新日期：2016-08-01 00:00:00

abstract：:Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level ...

journal_title：Oncology letters

authors： Wang X,Jiang Y,Yuan M,Chen C,Wang K,Zhang Q,Zuo Y,Ren S

更新日期：2017-09-01 00:00:00

abstract：:[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...

journal_title：Oncology letters

authors： Li L,Mao X,Qin X,Zhou M,Xing H,Dong F,Jiang X,Zhuang W

更新日期：2019-05-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...

journal_title：Oncology letters

authors： Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

更新日期：2014-02-01 00:00:00

abstract：:The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...

journal_title：Oncology letters

authors： Zhao Z,Li C,Song Y,Wu Q,Qiao F,Fan H

更新日期：2012-02-01 00:00:00

abstract：:Exchange proteins directly activated by cAMP (EPACs) are crucial cyclic adenosine 3',5'-monophosphate- determined signaling pathway intercessors, which are associated with the pathogenesis of neurological disorders and numerous human diseases. To the best of our knowledge, the role of EPAC2 signaling via matrix metall...

journal_title：Oncology letters

authors： Jiang M,Zhuang Y,Zu WC,Jiao L,Richard SA,Zhang S

更新日期：2019-06-01 00:00:00

abstract：:Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...

journal_title：Oncology letters

authors： Sun H,Hu P,Du J,Wang X

更新日期：2018-03-01 00:00:00

abstract：:The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...

journal_title：Oncology letters

authors： Otowa Y,Nakamura T,Takiguchi G,Urakawa N,Ishida R,Imanishi T,Suzuki S,Tanaka K,Kuroda D,Kakeji Y

更新日期：2015-06-01 00:00:00

abstract：:Cisplatin-resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin-based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of ...

journal_title：Oncology letters

authors： Li Q,Zhang J,Zhou J,Yang B,Liu P,Cao L,Jing L,Liu H

更新日期：2018-06-01 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

journal_title：Oncology letters

authors： Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

更新日期：2013-05-01 00:00:00

abstract：:The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...

journal_title：Oncology letters

authors： Scapulatempo-Neto C,Veo C,Fregnani JHTG,Lorenzi A,Mafra A,Melani AGF,Loaiza EAA,Rosa LAR,de Oliveira CM,Levi JE,Longatto-Filho A

更新日期：2017-03-01 00:00:00

abstract：:The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...

journal_title：Oncology letters

authors： Li Y,Liu L,Yin Z,Xu H,Li S,Tao W,Cheng H,Du L,Zhou X,Zhang B

更新日期：2017-02-01 00:00:00

abstract：:Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...

journal_title：Oncology letters

authors： Marech I,Vacca A,Sivestris N,Gnoni A,Lorusso V

更新日期：2013-06-01 00:00:00

abstract：:Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...

journal_title：Oncology letters

authors： Kim J,Jung J,Lee SJ,Lee JS,Park MJ

更新日期：2012-03-01 00:00:00

abstract：:It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...

journal_title：Oncology letters

authors： Pan S,Cai H,Gu L,Cao S

更新日期：2017-11-01 00:00:00

abstract：:Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...

journal_title：Oncology letters

authors： Wang J,Hua L,Guo M,Yang L,Liu X,Li Y,Shang X,Luo J

更新日期：2017-06-01 00:00:00

abstract：:Glucose Transporter 1 (GLUT1) belongs to the expanding mammalian facilitative glucose transporter family. Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. Whereas malignant cells have an accelerated metabolism with inc...

journal_title：Oncology letters

authors： Reis H,Tschirdewahn S,Szarvas T,Rübben H,Schmid KW,Grabellus F

更新日期：2011-11-01 00:00:00

abstract：:In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...

journal_title：Oncology letters

authors： Yan Y,Wu Q,Li ZY,Bu ZD,Ji JF

更新日期：2019-03-01 00:00:00

abstract：:microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...

journal_title：Oncology letters

authors： Li L,Jia L,Ding Y

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to identify differences in protein expression in cases of endometrioid endometrial cancer (EEC) with and without coexisting adenomyosis uteri (AM), and to evaluate the histopathological and prognostic distinctions. The total cohort included 22 patients in Group A (patients with concomitant AM a...

journal_title：Oncology letters

authors： Hertlein L,Rath J,Zeder-Göss C,Fürst S,Bayer D,Trillsch F,Mahner S,Burges A,Jeschke U

更新日期：2017-09-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...

journal_title：Oncology letters

authors： Kasai S,Sasaki T,Watanabe A,Nishiya M,Yasuhira S,Shibazaki M,Maesawa C

更新日期：2017-07-01 00:00:00

abstract：:In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and...

journal_title：Oncology letters

authors： Xu XM,Zhang ML,Zhang Y,Zhao L

更新日期：2016-11-01 00:00:00

abstract：:Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....

journal_title：Oncology letters

authors： Li X,Yan ML,Yu Q

更新日期：2017-06-01 00:00:00

abstract：:Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...

journal_title：Oncology letters

authors： Liu JF,Zhao LR,Lu LJ,Chen L,Liu ZG,Gong X,Liu B

更新日期：2014-11-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

journal_title：Oncology letters

authors： Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

更新日期：2016-12-01 00:00:00

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00