Interaction between regulatory T cells and mast cells via IL-9 and TGF-β production.

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide. The present study investigated the effects of K9(C4H4FN2O2)2Nd(PW11O39)2·25H2O (FNdPW), a chemically synthesized polyoxometalate that contains rare earth elements, on lung cancer growth, and explored the mechanism underlying its actions. The ef...

journal_title：Oncology letters

authors： Xia RY,Zhang RR,Jiang Z,Sun YJ,Liu J,Chen FH

更新日期：2017-03-01 00:00:00

abstract：:A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...

journal_title：Oncology letters

authors： Mantas D,Kostakis ID,Machairas N,Markopoulos C

更新日期：2016-08-01 00:00:00

abstract：:Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...

journal_title：Oncology letters

authors： Zeng C,Wen M,Liu X

更新日期：2018-04-01 00:00:00

abstract：:Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...

journal_title：Oncology letters

authors： Jin S,Xu C,Wang L,Wei J,Wang S

更新日期：2021-02-01 00:00:00

abstract：:The present study analyzed polymorphisms of the 5' flanking region (from nt -840 to +151) of the haptoglobin gene in 120 patients with advanced non-small cell lung cancer (NSCLC) receiving personalized peptide vaccinations. In the region, six single nucleotide polymorphisms (SNPs) were confirmed, of which two, rs5472 ...

journal_title：Oncology letters

authors： Waki K,Yamada T,Yoshiyama K,Terazaki Y,Sakamoto S,Sugawara S,Takamori S,Itoh K,Yamada A

更新日期：2017-02-01 00:00:00

abstract：:The present study evaluated the expression of p53, pRb, hMLH1 and MDM2 prior to preoperative chemoradiotherapy (CRT) in patients with rectal cancer, and attempted to determine any correlation with treatment outcome. Forty-five patients with available pretreatment biopsy tissues and who received preoperative CRT were e...

journal_title：Oncology letters

authors： Nam TK,Lee JS,Kim HR,Ahn SJ,Song JY,Yoon MS

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to present the results of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC), and to clarify patient characteristics by investigating patient background factors. A total of 59 patients with EC, who received MPA as fertility-sparing therapy a...

journal_title：Oncology letters

authors： Fujiwara H,Jobo T,Takei Y,Saga Y,Imai M,Arai T,Taneichi A,Machida S,Takahashi Y,Suzuki M

更新日期：2012-05-01 00:00:00

abstract：:Metastasis remains a notable issue in patients with newly diagnosed colorectal carcinomas (CRC). Although anti-angiogenic therapies target metastatic diseases, hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor (VEGF) status are routinely evaluated in primary tumors as metastatic sites are in...

journal_title：Oncology letters

authors： Yin L,Li J,Ma D,Li D,Sun Y

更新日期：2020-05-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00

abstract：:Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study exami...

journal_title：Oncology letters

authors： Yanai Y,Hayashi T,Akazawa Y,Yatagai N,Tsuyama S,Yao T,Saito T

更新日期：2020-07-01 00:00:00

abstract：:The present study aimed to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two human colon carcinoma cell lines, DLD-1 and WiDr. Colon carcinoma cells were treated with various concentrations of aloe-emodin for different durations. Cell viability was m...

journal_title：Oncology letters

authors： Lin KY,Uen YH

更新日期：2010-05-01 00:00:00

abstract：:Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...

journal_title：Oncology letters

authors： Wu YL,Zhou L,Lu Y

更新日期：2016-08-01 00:00:00

abstract：:The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were p...

journal_title：Oncology letters

authors： Huang J,Chen H,Wei Q,Zhang Z,Zhong Z,Xu Y

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to investigate whether ultrasound combined with microbubbles was able to enhance liposome-mediated transfection of genes into human prostate cancer cells, and to examine the association between autophagy and tumor protein P53 (P53). An MTT assay was used to evaluate cell viability, whi...

journal_title：Oncology letters

authors： Wang YU,Chen YN,Zhang W,Yang YU,Bai WK,Shen E,Hu B

更新日期：2016-01-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72...

journal_title：Oncology letters

authors： Liu Z,Li Y,Yang R

更新日期：2012-10-01 00:00:00

abstract：:Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable p...

journal_title：Oncology letters

authors： Fusco P,Esposito MR,Tonini GP

更新日期：2018-12-01 00:00:00

abstract：:MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...

journal_title：Oncology letters

authors： Wang G,Zhao R,Zhao X,Chen XI,Wang D,Jin Y,Liu XI,Zhao CI,Zhu Y,Ren C,Li M,Jin X,Zhang F,Zhong Z,Wang T,Li X

更新日期：2015-11-01 00:00:00

abstract：:Targeted therapy of non-small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated with improved prognosis. However, there is a shortage on data from real-world clinical practice in management of EGFR-positive NSCLC patients in Poland. The present stu...

journal_title：Oncology letters

authors： Ramlau R,Krawczyk P,Dziadziuszko R,Chmielewska I,Milanowski J,Olszewski W,Stencel K,Ramlau-Piątek K,Segiet A,Skroński M,Grudny J,Chorostowska-Wynimko J

更新日期：2017-11-01 00:00:00

abstract：:Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4...

journal_title：Oncology letters

authors： Zhao JA,Sang MX,Geng CZ,Wang SJ,Shan BE

更新日期：2016-11-01 00:00:00

abstract：:Abnormal glucose metabolism is critical in colorectal cancer (CRC) development. Expression of the pyruvate kinase (PK) M2 isoform, rather than the PKM1 isoform, serves important functions in reprogramming the glucose metabolism of cancer cells. Preferential expression of PKM2 is primarily driven by alternative splicin...

journal_title：Oncology letters

authors： Sun Y,Luo M,Chang G,Ren W,Wu K,Li X,Shen J,Zhao X,Hu Y

更新日期：2017-12-01 00:00:00

abstract：:The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV...

journal_title：Oncology letters

authors： Loizou C,Laurell G,Lindquist D,Öfverman C,Stefansson K,Nylander K,Olofsson K

更新日期：2015-12-01 00:00:00

abstract：:Effects of miR-135a-5p and miR-141 on the biological function of colorectal cancer SW620 cells were investigated. Fifty-four specimens of cancer tissues and 54 specimens of corresponding adjacent tissues in colon cancer patients who were treated in The Central Hospital of Wuhan from March 2014 to March 2015 were colle...

journal_title：Oncology letters

authors： Wang J,Yang J,Zhang H,Liao Y,Xu D,Ma S

更新日期：2020-07-01 00:00:00

abstract：:The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...

journal_title：Oncology letters

authors： Lu CZ,Cao SS,Wang W,Liu J,Fu N,Lu F

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to investigate the expression levels and clinical value of miR-365 and miR-25 in serum of patients with non-small cell lung cancer (NSCLC). Patients (180) diagnosed with NSCLC at the Affiliated Hospital of Guangdong Medical University from July 2011 to December 2013 were used as the experimenta...

journal_title：Oncology letters

authors： Huang D,Ou W,Tong H,Peng M,Ou Y,Song Z

更新日期：2020-11-01 00:00:00

abstract：:Fatty acid-binding protein 5 (FABP5), which participates in mediating the biological properties of tumor cells, has been recognized in several neoplasms. The present study aims to investigate FABP5 transcriptional expression profiles, reveal its underlying biological interaction networks and define its prognostic valu...

journal_title：Oncology letters

authors： Xu Y,Xu WH,Yang XL,Zhang HL,Zhang XF

更新日期：2020-03-01 00:00:00

abstract：:Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability of anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In the present study, using human GCA conjugated with ...

journal_title：Oncology letters

authors： Wu M,Zhai S,Gao J,Wei D,Xue J,Zhou Y,Li N,Hu L

更新日期：2019-03-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is associated with a history of heavy, long-term exposure to asbestos. However, MPM may also be associated with simian virus 40 (SV40), a polyomavirus. The association between SV40 and MPM remains unclear. The present study was conducted in order to investigate the proportion of SV...

journal_title：Oncology letters

authors： Thanh TD,Tho NV,Lam NS,Dung NH,Tabata C,Nakano Y

更新日期：2016-03-01 00:00:00

abstract：:Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...

journal_title：Oncology letters

authors： Guan N,Wang R,Feng X,Li C,Guo W

更新日期：2020-09-01 00:00:00

abstract：:The present study aims to investigate the radiosensitization effect of the migration and invasion inhibitory protein (MIIP) gene on nasopharyngeal carcinoma (NPC) cells. The MIIP gene was transfected into NPC 5-8F and CNE2 cells. The level of MIIP was analyzed by quantitative reverse transcription-polymerase chain rea...

journal_title：Oncology letters

authors： Zhou HP,Qian LX,Zhang N,Gu JJ,Ding K,Wu J,Lu ZW,Du MY,Zhu HM,Wu JZ,He X,Yin L

更新日期：2018-06-01 00:00:00

abstract：:The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microe...

journal_title：Oncology letters

authors： Neagu M,Constantin C,Caruntu C,Dumitru C,Surcel M,Zurac S

更新日期：2019-05-01 00:00:00