Abstract:
:Effects of miR-135a-5p and miR-141 on the biological function of colorectal cancer SW620 cells were investigated. Fifty-four specimens of cancer tissues and 54 specimens of corresponding adjacent tissues in colon cancer patients who were treated in The Central Hospital of Wuhan from March 2014 to March 2015 were collected. RT-PCR was used to detect the expression levels of miR-135a-5p and miR-141 in cancer tissues and adjacent tissues. The miR-135a-5p inhibitor and miR-141 mimic carriers were established. The cell proliferation was detected by CCK8, the invasion ability of cells in vitro was evaluated by Transwell chamber, and cell apoptosis of each group was detected by flow cytometry. The results of RT-qPCR showed that expression levels of miR-135a-5p in colorectal cancer tissues were significantly higher than those in adjacent tissues, the expression levels of miR-141 in colorectal cancer tissues were significantly lower than those in adjacent tissues, and the difference was statistically significant (P<0.001). The cell survival rates of the miR-135a-5p inhibitor group and the miR-141 mimic group were significantly lower than those of the NC group and the blank group 48 and 72 h after transfection (P<0.001). The number of invasive cells in the miR-135a-5p inhibitor group and the miR-141 mimic group was significantly lower than that in the blank group and the NC group (P<0.001). Apoptosis rate was significantly higher than that of the NC group and the blank group (P<0.001). In conclusion, low expression levels of miR-135a-5p and miR-141 in colorectal adenomas suggested that miR-135a-5p and miR-141 could act as tumor suppressors in the development of colorectal adenomas; miR-135a-5p and miR-141 inhibited the proliferation and invasion of colon cancer SW620 cells and promoted apoptosis of colon cancer cells.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang J,Yang J,Zhang H,Liao Y,Xu D,Ma Sdoi
10.3892/ol.2020.11598subject
Has Abstractpub_date
2020-07-01 00:00:00pages
914-920issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-11598journal_volume
20pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β-catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear loca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4958
更新日期:2016-10-01 00:00:00
abstract::Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8359
更新日期:2018-06-01 00:00:00
abstract::The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4541
更新日期:2016-06-01 00:00:00
abstract::The outcomes of matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) remain controversial. The clinical outcome in patients that undergo transplantation following failed IST is typically poorer when compared with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2341
更新日期:2014-10-01 00:00:00
abstract::Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. To the best o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6676
更新日期:2017-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4687
更新日期:2016-08-01 00:00:00
abstract::Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10499
更新日期:2019-08-01 00:00:00
abstract::Mangiferin, a flavonoid extracted from the mango tree, possesses anti-inflammatory, antibacterial, anti-herpes simplex and antitumor activity, and is able to affect immune function. The present study investigated the anticancer effects of mangiferin treatment on PC3 human prostate cancer cells, and the potential under...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3924
更新日期:2016-01-01 00:00:00
abstract::It has been proposed that cancer stem cells (CSCs) are involved in tumor resistance to chemotherapy and tumor relapse. The goal of the present study was to determine the effect of low-dose 5-fluorouracil (5-Fu) on enriched hepatocellular CSC-like cells. Increased cell motility and epithelial-mesenchymal transition wer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4975
更新日期:2016-10-01 00:00:00
abstract::Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7982
更新日期:2018-04-01 00:00:00
abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1725
更新日期:2014-02-01 00:00:00
abstract::The aim of the present study was to evaluate the expression of peroxisome proliferator-activated receptor (PPAR)-γ in inflammatory bowel disease (IBD), and to also identify the association between PPAR-γ and the clinical features of patients with IBD. An azoxymethane (AOM)/dextran sodium sulfate (DSS) animal model of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3397
更新日期:2015-09-01 00:00:00
abstract::Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1904
更新日期:2014-05-01 00:00:00
abstract::The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000055
更新日期:2010-03-01 00:00:00
abstract::Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11008
更新日期:2019-12-01 00:00:00
abstract::Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10783
更新日期:2019-11-01 00:00:00
abstract::The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9510
更新日期:2019-01-01 00:00:00
abstract::The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8388
更新日期:2018-06-01 00:00:00
abstract::Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10802
更新日期:2019-11-01 00:00:00
abstract::The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.814
更新日期:2012-10-01 00:00:00
abstract::In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3289
更新日期:2015-08-01 00:00:00
abstract::The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8669
更新日期:2018-07-01 00:00:00
abstract::Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2089
更新日期:2014-07-01 00:00:00
abstract::The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5325
更新日期:2016-12-01 00:00:00
abstract::Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10737
更新日期:2019-10-01 00:00:00
abstract::The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1000
更新日期:2013-01-01 00:00:00
abstract::Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5154
更新日期:2016-11-01 00:00:00
abstract::The aim of the present study was to investigate the safety and efficacy of long intestinal tube placement under fluoroscopic guidance for the treatment of malignant bowel obstruction (MBO). The cases of 74 patients with MBO who underwent long intestinal tube placement under fluoroscopic guidance during the period betw...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10151
更新日期:2019-06-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most frequent cancer worldwide with a poor 5-year survival. miR-650 acts as an oncogene and regulates tumor progress in various cancers. Molecular mechanisms of miR-650 in NSCLC cell proliferation and invasion was studied. The mRNA levels of miR-650 and special genes were calc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10805
更新日期:2019-11-01 00:00:00
abstract::Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10644
更新日期:2019-09-01 00:00:00