Abstract:
:It has been proposed that cancer stem cells (CSCs) are involved in tumor resistance to chemotherapy and tumor relapse. The goal of the present study was to determine the effect of low-dose 5-fluorouracil (5-Fu) on enriched hepatocellular CSC-like cells. Increased cell motility and epithelial-mesenchymal transition were observed by migration assay in human hepatoblastoma PLC/RAF/5 cells following 5-Fu treatment, as well as a significant enhancement in their sphere-forming abilities. CSC-like cells were identified by side population cell analysis. The percentage of CSC-like cells in the surviving cells was greatly increased in response to 5-Fu. These findings indicate that low-dose 5-Fu treatment may efficiently enrich the CSC-like cell population in PLC/RAF/5 cells.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhan Y,Mou L,Cheng K,Wang C,Deng X,Chen J,Fan Z,Ni Ydoi
10.3892/ol.2016.4975subject
Has Abstractpub_date
2016-10-01 00:00:00pages
2511-2516issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-4975journal_volume
12pub_type
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