Correlations between the MEG-A3 gene and incidence of breast cancer.

Abstract:

:The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same patient was measured at different time-points (1, 3, 6, 8, 12 and 24 months), and the protein expression levels were determined using western blotting. The results showed that, the mRNA level in MEG-A3 gene of samples of patients with breast cancer was significantly higher than that of normal women (p<0.05). The MEG-A3 gene expression increased apparently with the prolongation and aggravation of the disease. In conclusion, there is a close correlation between MEG-A3 gene and the incidence of breast cancer; thus, MEG-A3 gene contributes to the occurrence and deterioration of breast cancer to some extent. It provides a theoretical basis for later disease treatment.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Hou X,Guo F,Sun Q

doi

10.3892/ol.2016.5325

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

4925-4928

issue

6

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-5325

journal_volume

12

pub_type

杂志文章
  • Chromosome instability in neuroblastoma.

    abstract::Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable p...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2018.9545

    authors: Fusco P,Esposito MR,Tonini GP

    更新日期:2018-12-01 00:00:00

  • Prognostic genes of breast cancer revealed by gene co-expression network analysis.

    abstract::The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coeffic...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6779

    authors: Shi H,Zhang L,Qu Y,Hou L,Wang L,Zheng M

    更新日期:2017-10-01 00:00:00

  • Comprehensive genomic profile of cholangiocarcinomas in China.

    abstract::Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11429

    authors: Tian W,Hu W,Shi X,Liu P,Ma X,Zhao W,Qu L,Zhang S,Shi W,Liu A,Cao J

    更新日期:2020-04-01 00:00:00

  • Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literature.

    abstract::No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with a...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1217

    authors: Ye B,Li W,Feng J,Shi JX,Chen Y,Han BH

    更新日期:2013-05-01 00:00:00

  • Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literature.

    abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.900

    authors: Park JH,Choi JY,Hong R,DO NY

    更新日期:2012-12-01 00:00:00

  • Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins.

    abstract::In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5170

    authors: Xu XM,Zhang ML,Zhang Y,Zhao L

    更新日期:2016-11-01 00:00:00

  • Conjunctival lymphomas in Japanese monozygotic twins: A case report.

    abstract::An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9723

    authors: Ishibashi N,Sugaya S,Takahashi H,Nishimaki H,Nakanishi Y,Chinen Y,Maebayashi T

    更新日期:2019-01-01 00:00:00

  • Foot sarcomas: Factors affecting oncological and functional outcomes.

    abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.427

    authors: Kozawa E,Nishida Y,Nakashima H,Tsukushi S,Toriyama K,Kamei Y,Ishiguro N

    更新日期:2012-01-01 00:00:00

  • Serum B-type natriuretic peptide levels as a marker for anthracycline-induced cardiotoxicity.

    abstract::Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4424

    authors: Wang YD,Chen SX,Ren LQ

    更新日期:2016-05-01 00:00:00

  • High expression of HVEM is associated with improved prognosis in intrahepatic cholangiocarcinoma.

    abstract::Herpesvirus entry mediator (HVEM) displays dual signals in T-cell activation according to the ligands and intracytoplasmic effectors it interacts with. High HVEM expression may play an immunosuppressive role in several malignancies. The present study investigated the clinical impact of HVEM on intrahepatic cholangioca...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.12330

    authors: Ma B,Meng H,Tian Y,Wang Y,Song T,Zhang T,Wu Q,Cui Y,Li H,Zhang W,Li Q

    更新日期:2021-01-01 00:00:00

  • Descending colo-colonic intussusception secondary to signet ring cell carcinoma: A case report.

    abstract::The incidence of intussusception is low in adults, particularly in the descending colon, due to the anatomical attachment of the descending colon to the retroperitoneum. Signet ring cell histology represents ~1% of colon adenocarcinomas and is associated with young patients and a poor clinical outcome. The present stu...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2805

    authors: Sun KK,Yang D,Gan M,Wu XY

    更新日期:2015-03-01 00:00:00

  • Multicenter, phase II clinical trial of peptide vaccination with oral chemotherapy following curative resection for stage III colorectal cancer.

    abstract::The safety and immunological responsiveness of a peptide vaccine of ring finger protein 43 and 34-kDa translocase of the outer mitochondrial membrane combined with uracil-tegafur/leucovorin (UFT/LV) was previously demonstrated in metastatic colorectal cancer (CRC) in a phase I clinical trial. To clarify the survival b...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7905

    authors: Kawamura J,Sugiura F,Sukegawa Y,Yoshioka Y,Hida JI,Hazama S,Okuno K

    更新日期:2018-04-01 00:00:00

  • Port-site metastasis as a primary complication following retroperitoneal laparoscopic radical resection of renal pelvis carcinoma or nephron-sparing surgery: A report of three cases and review of the literature.

    abstract::The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4541

    authors: Wang N,Wang K,Zhong D,Liu X,Sun JI,Lin L,Ge L,Yang BO

    更新日期:2016-06-01 00:00:00

  • Inflammatory cytokines, appetite-regulating hormones, and energy metabolism in patients with gastrointestinal cancer.

    abstract::This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11662

    authors: Shinsyu A,Bamba S,Kurihara M,Matsumoto H,Sonoda A,Inatomi O,Andoh A,Takebayashi K,Kojima M,Iida H,Tani M,Sasaki M

    更新日期:2020-08-01 00:00:00

  • Screening and identification of key biomarkers in bladder carcinoma: Evidence from bioinformatics analysis.

    abstract::Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9002

    authors: Yan M,Jing X,Liu Y,Cui X

    更新日期:2018-09-01 00:00:00

  • PET/CT imaging analysis of recurrent sites and patterns of spread following modified radical surgery (type B) for stage Ib-IIa cervical cancer.

    abstract::The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9070

    authors: Cheng S,Li Y,Zhang M,Tong T

    更新日期:2018-09-01 00:00:00

  • Outcome in disappearing colorectal cancer liver metastases during oxaliplatin-based chemotherapy.

    abstract::Some colorectal cancer liver metastases (CLMs) disappear on serial imaging during chemotherapy and the optimal treatment strategy for such lesions remains undetermined. The purpose of this study was to investigate the outcome in disappearing CLMs, as few studies have focused on this topic, with conflicting results. Am...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.842

    authors: Ono T,Ishida H,Kumamoto K,Okada N,Ishibashi K

    更新日期:2012-11-01 00:00:00

  • Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples.

    abstract::Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog (PT...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8626

    authors: Nakamura K,Nakayama K,Ishikawa M,Minamoto T,Ishibashi T,Sato E,Sanuki K,Yamashita H,Ono R,Iida K,Sultana R,Hossain MM,Ishikawa N,Kyo S

    更新日期:2018-07-01 00:00:00

  • Role of wild-type p53-induced phosphatase 1 in cancer.

    abstract::Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response system. It has been reported to dephosphorylate p53, ataxia telangiectasia mutated, che...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6685

    authors: Wang ZP,Tian Y,Lin J

    更新日期:2017-10-01 00:00:00

  • Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer.

    abstract::With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10113

    authors: Jeon YH,Ha M,Kim SW,Kim MJ,Lee CS,Oh CK,Han ME,Oh SO,Kim YH

    更新日期:2019-05-01 00:00:00

  • Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.

    abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.522

    authors: Lee H,Choi SK,Ro JY

    更新日期:2012-03-01 00:00:00

  • Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells.

    abstract::Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5415

    authors: Meng L,Xu G,Li J,Liu W,Jia W,Ma J,Wei D

    更新日期:2017-01-01 00:00:00

  • Prospective evaluation of cisplatin- and carboplatin-mediated ototoxicity in paediatric and adult soft tissue and osteosarcoma patients.

    abstract::Platinum-compound chemotherapy is known to have ototoxic side-effects. However, there is a paucity of literature examining hearing function prospectively and longitudinally in cohorts containing paediatric and adult patients treated within the same cisplatin- or carboplatin-containing treatment trial protocols. In Ger...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.997

    authors: Nitz A,Kontopantelis E,Bielack S,Koscielniak E,Klingebiel T,Langer T,Paulides M

    更新日期:2013-01-01 00:00:00

  • Genetic alterations in epidermal growth factor receptor-tyrosine kinase inhibitor-naïve non-small cell lung carcinoma.

    abstract::Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11524

    authors: Yamaura T,Muto S,Mine H,Takagi H,Watanabe M,Ozaki Y,Inoue T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

    更新日期:2020-06-01 00:00:00

  • Downregulation of cytochrome c oxidase 1 induced radioresistance in esophageal squamous cell carcinoma.

    abstract::Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6699

    authors: Takesue T,Kawakubo H,Hayashida T,Tsutsui M,Miyao K,Fukuda K,Nakamura R,Takahashi T,Wada N,Takeuchi H,Kitagawa Y

    更新日期:2017-10-01 00:00:00

  • An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype.

    abstract::A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, part...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7742

    authors: Yang M,Xu J,Wang Q,Zhang AQ,Wang K

    更新日期:2018-03-01 00:00:00

  • Pharmacokinetics of continuous transarterial infusion of 5-fluorouracil in patients with advanced hepatocellular carcinoma.

    abstract::Numerous studies concerning hepatic arterial infusion chemotherapy (HAIC) have been conducted by adopting regimens containing 5-fluorouracil (FU), with a favourable efficacy compared with conventional transcatheter arterial chemoembolisation (TACE) treatment; however, the detailed mechanism of HAIC remains unclear. Th...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8242

    authors: Gao J,Zhen R,Liao H,Zhuang W,Guo W

    更新日期:2018-05-01 00:00:00

  • Melatonin treatment induces apoptosis through regulating the nuclear factor-κB and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells.

    abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5785

    authors: Li W,Wang Z,Chen Y,Wang K,Lu T,Ying F,Fan M,Li Z,Wu J

    更新日期:2017-04-01 00:00:00

  • Endocrine disruptors from the environment affecting breast cancer.

    abstract::Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2020.11566

    authors: Calaf GM,Ponce-Cusi R,Aguayo F,Muñoz JP,Bleak TC

    更新日期:2020-07-01 00:00:00

  • Advanced prostatic ductal carcinoma in a patient with a long survival time following a total pelvis exenteration: A case report.

    abstract::Ductal adenocarcinoma of the prostate (DAP) is a rare variant of prostate cancer, and has poorly-identified clinical characteristics. Few cases have been previously reported in Chinese males and DAP is more commonly reported in Caucasian males over 70-years of age. In the present study, a 55-year-old Chinese male pati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4098

    authors: Ji C,Zhou M,Gan W,Zheng J,Yan X,Guo H

    更新日期:2016-02-01 00:00:00