Abstract:
:The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same patient was measured at different time-points (1, 3, 6, 8, 12 and 24 months), and the protein expression levels were determined using western blotting. The results showed that, the mRNA level in MEG-A3 gene of samples of patients with breast cancer was significantly higher than that of normal women (p<0.05). The MEG-A3 gene expression increased apparently with the prolongation and aggravation of the disease. In conclusion, there is a close correlation between MEG-A3 gene and the incidence of breast cancer; thus, MEG-A3 gene contributes to the occurrence and deterioration of breast cancer to some extent. It provides a theoretical basis for later disease treatment.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Hou X,Guo F,Sun Qdoi
10.3892/ol.2016.5325subject
Has Abstractpub_date
2016-12-01 00:00:00pages
4925-4928issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-5325journal_volume
12pub_type
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