Upregulation of ULK1 expression in PC-3 cells following tumor protein P53 transfection by sonoporation.

abstract：:A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...

journal_title：Oncology letters

authors： Gao H,Huang Z,Shi C,Li H

更新日期：2015-02-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the f...

journal_title：Oncology letters

authors： Al-Khallaf H,Alali H,Alkhatti A

更新日期：2018-11-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...

journal_title：Oncology letters

authors： Tian W,Hu W,Shi X,Liu P,Ma X,Zhao W,Qu L,Zhang S,Shi W,Liu A,Cao J

更新日期：2020-04-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2018.8006.]. ...

journal_title：Oncology letters

authors： Xu F,Zhu Y,Lu Y,Yu Z,Zhong J,Li Y,Pan J

更新日期：2020-11-01 00:00:00

abstract：:Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of...

journal_title：Oncology letters

authors： Li BQ,Huang S,Shao QQ,Sun J,Zhou L,You L,Zhang TP,Liao Q,Guo JC,Zhao YP

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...

journal_title：Oncology letters

authors： Liu F,Qi CL,Kong M,Liu TT,Li L,Li BJ

更新日期：2016-12-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowle...

journal_title：Oncology letters

authors： Wei YB,Gao YL,Wu HT,Ou-Yang SF,Xu T,Mao DF,Yang JR

更新日期：2015-01-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:Studies investigating the effects of microRNA (miR)-155 on the behavior of tumor cells have concentrated primarily on proliferation and apoptosis. The aim of the present study was to investigate the effect of miR-155 inhibitor on the metastatic and invasive ability of gastric carcinoma cells and whether this effect is...

journal_title：Oncology letters

authors： Wei H,Li Y,Ning Q,Suo ZM

更新日期：2018-10-01 00:00:00

abstract：:The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...

journal_title：Oncology letters

authors： Zhou Z,Ware JH,Kennedy AR

更新日期：2011-09-01 00:00:00

abstract：:Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...

journal_title：Oncology letters

authors： Liu JF,Zhao LR,Lu LJ,Chen L,Liu ZG,Gong X,Liu B

更新日期：2014-11-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is associated with a history of heavy, long-term exposure to asbestos. However, MPM may also be associated with simian virus 40 (SV40), a polyomavirus. The association between SV40 and MPM remains unclear. The present study was conducted in order to investigate the proportion of SV...

journal_title：Oncology letters

authors： Thanh TD,Tho NV,Lam NS,Dung NH,Tabata C,Nakano Y

更新日期：2016-03-01 00:00:00

abstract：:Nucleobindin 2 (NUCB-2) is a multifunctional protein that contains several functional domains and is associated with a wide variety of biological processes, such as food intake and energy homeostasis. NUCB-2 has been demonstrated to be associated with worse malignant outcomes and cell migration in breast and prostate ...

journal_title：Oncology letters

authors： Tao R,Niu WB,Dou PH,Ni SB,Yu YP,Cai LC,Wang XY,Li SY,Zhang C,Luo ZG

更新日期：2020-06-01 00:00:00

abstract：:The aim of the present study was to determine the impact of obesity on radiation-induced gastrointestinal (GI) and genitourinary (GU) toxicity. The cases of 54 patients with prostate cancer, treated with three-dimensional conformal radiation therapy (RT), were reviewed. For each patient, the body mass index (BMI), dis...

journal_title：Oncology letters

authors： Doi H,Ishimaru F,Tanooka M,Inoue H,Odawara S,Takada Y,Niwa Y,Fujiwara M,Kamikonya N,Yamamoto S,Hirota S

更新日期：2014-01-01 00:00:00

abstract：:MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...

journal_title：Oncology letters

authors： Yin J,Wang M,Jin C,Qi Q

更新日期：2014-02-01 00:00:00

abstract：:Primary mediastinal extraskeletal Ewing's sarcoma (EES) is quite rare. To the best of our knowledge, only five cases have been reported. Given the paucity of data, there is consequently no optimal treatment strategy available. The current study presents the case of a 51-year-old female with unresectable EES of the pos...

journal_title：Oncology letters

authors： Liu M,Liu B,Dong L,Han T,Zhang L

更新日期：2015-02-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer worldwide. However, operative diagnostic and prognostic systems for ESCC remain to be established. To improve assessment of the prognosis for patients with ESCC, the present study developed an online consensus survival tool for ESCC, t...

journal_title：Oncology letters

authors： Wang Q,Wang F,Lv J,Xin J,Xie L,Zhu W,Tang Y,Li Y,Zhao X,Wang Y,Li X,Guo X

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...

journal_title：Oncology letters

authors： Yuan F,Zhang S,Xie W,Yang S,Lin T,Chen X

更新日期：2020-06-01 00:00:00

abstract：:Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to i...

journal_title：Oncology letters

authors： Zhou W,Zhu W,Ma L,Xiao F,Qian W

更新日期：2015-11-01 00:00:00

abstract：:The chemokine CXCL10 and its receptor CXCR3 have been demonstrated to be implicated in cancer cell proliferation and metastasis. CXCR3 has three splice variants: CXCR3A, CXCR3B and CXCR3-alt. CXCR3A and B serve multiple roles in the growth and invasiveness of a number of cancer types. However, the roles of CXCR3 isofo...

journal_title：Oncology letters

authors： Nozaki E,Kobayashi T,Ohnishi H,Ohtsuka K,Masaki T,Watanabe T,Sugiyama M

更新日期：2020-03-01 00:00:00

abstract：:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...

journal_title：Oncology letters

authors： Wan S,Zhao H

更新日期：2020-11-01 00:00:00

abstract：:Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...

journal_title：Oncology letters

authors： Rath-Wolfson L,Bergman M,Ori Y,Goldman A,Ram E,Koren R,Salman H

更新日期：2013-01-01 00:00:00

abstract：:Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...

journal_title：Oncology letters

authors： He J,Li Y,Wang Y,Zhang H,Ge S,Fan X

更新日期：2018-05-01 00:00:00

abstract：:Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to augmentation of AD...

journal_title：Oncology letters

authors： Nakajima T,Okayama H,Ashizawa M,Noda M,Aoto K,Saito M,Monma T,Ohki S,Shibata M,Takenoshita S,Kono K

更新日期：2018-02-01 00:00:00

abstract：:The Klotho (KL) gene was first identified as a potent aging suppressor. The KL family currently comprises of three proteins: α-Klotho (KLA), β-Klotho (KLB), and γ-Klotho (KLG). Many studies have shown that KLA and KLB participate in tumor progression or suppression, depending on the type of cancer; however, the relati...

journal_title：Oncology letters

authors： Onishi K,Miyake M,Hori S,Onishi S,Iida K,Morizawa Y,Tatsumi Y,Nakai Y,Tanaka N,Fujimoto K

更新日期：2020-03-01 00:00:00

abstract：:Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, whic...

journal_title：Oncology letters

authors： Guan Z,Lan H,Sun D,Wang X,Jin K

更新日期：2019-02-01 00:00:00

abstract：:In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Sueishi M

更新日期：2014-10-01 00:00:00

abstract：:This study investigated the inhibitory effect of vitamin D-binding protein-derived macrophage-activating factor (GcMAF) on carcinogenesis and tumor growth, using a 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster cheek pouch carcinogenesis model, as well as the cytocidal effect of activated macrophages against ...

journal_title：Oncology letters

authors： Toyohara Y,Hashitani S,Kishimoto H,Noguchi K,Yamamoto N,Urade M

更新日期：2011-07-01 00:00:00

abstract：:Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...

journal_title：Oncology letters

authors： Yan C,Wang C,Dong M,Liu S,Qi C,Zhao Y

更新日期：2013-03-01 00:00:00