Abstract:
:Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of WTAP on pancreatic ductal adenocarcinoma (PDAC) is still unknown. A total of 145 patients who underwent surgical treatment from 2004 to 2008 were enrolled in the present study. The cytoplasmic and nuclear expression of WTAP in tumor and adjacent normal tissues was examined by immunohistochemical analysis in order to investigate the relationship between WTAP and the clinicopathological factors and prognosis of patients with PDAC. The nuclear and cytoplasmic expression of WTAP in tumor tissues was significantly higher compared with non-tumor tissues (P<0.001). High expression of WTAP in the nucleus was significantly associated with gender (P=0.010) and tumor stage (P=0.020), while high expression of WTAP in the cytoplasm was significantly associated with gender (P=0.018), histological grade (P=0.047) and perineural invasion (P=0.028). In addition, a univariate analysis revealed that high nuclear expression of WTAP in tumor tissues was significantly associated with poor overall survival (P<0.001), as well as several clinicopathological variables, including gender and N stage. In a multivariate Cox regression analysis, nuclear WTAP expression was identified as an independent prognostic indicator for PDAC (relative risk, 1.855; 95% confidence interval, 1.033-3.333; P=0.039). The results of the present study indicated that high nuclear expression of WTAP is a valuable molecular biomarker of a poor prognosis among patients with PDAC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Li BQ,Huang S,Shao QQ,Sun J,Zhou L,You L,Zhang TP,Liao Q,Guo JC,Zhao YPdoi
10.3892/ol.2017.5784subject
Has Abstractpub_date
2017-04-01 00:00:00pages
2531-2538issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-5784journal_volume
13pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Regenerating islet-derived family, member 4 (REG4, which encodes Reg IV) is a marker for cancer and inflammatory bowel disease. This study aimed to investigate the diagnostic utility of Reg IV measurement in sera from esophageal cancer patients. Reg IV expression was examined in 269 esophageal cancer samples by immuno...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.239
更新日期:2011-03-01 00:00:00
abstract::Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3789
更新日期:2015-12-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4264
更新日期:2016-04-01 00:00:00
abstract::The aim of the present study was to investigate the effect of HPV16E6 gene integration on the biological behavior of Eca109 and Eca9706 cells. This was evaluated through positive liposome transfection of HPV16E6 into Eca109 cells and Eca9706 cells. The transfection efficiency was evaluated by calculating the ratio of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7469
更新日期:2018-02-01 00:00:00
abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5785
更新日期:2017-04-01 00:00:00
abstract::Ovarian cancer (OC) has the worst prognosis among all malignancy types in females worldwide according to epidemiological studies in 2017. Although radiotherapy, chemotherapy and surgical treatment are the most common treatment methods, their curative effects are not satisfactory. The present study aimed to examine the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10306
更新日期:2019-07-01 00:00:00
abstract::The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8983
更新日期:2018-09-01 00:00:00
abstract::Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10958
更新日期:2019-12-01 00:00:00
abstract::Transcriptional co-activator with PDZ-binding motif (TAZ) is a transcriptional co-activator which binds to a variety of transcription factors. An increasing number of studies have provided evidence that TAZ may be a positive regulator of cell proliferation and tumorigenesis. To reveal the underlying mechanisms by whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6030
更新日期:2017-06-01 00:00:00
abstract::Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7259
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3607
更新日期:2015-10-01 00:00:00
abstract::Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5099
更新日期:2016-11-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6844
更新日期:2017-11-01 00:00:00
abstract::Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3743
更新日期:2015-12-01 00:00:00
abstract::The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3248
更新日期:2015-07-01 00:00:00
abstract::The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7946
更新日期:2018-04-01 00:00:00
abstract::Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcino...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4548
更新日期:2016-06-01 00:00:00
abstract::The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8290
更新日期:2018-05-01 00:00:00
abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.427
更新日期:2012-01-01 00:00:00
abstract::It has been demonstrated that numerous types of metastatic cancer overexpress vacuolar-type H+ (V)-ATPases. It may be possible to inhibit the growth and metastasis of human cancer cells by inhibiting V-ATPases. It was previously reported that diphyllin, a novel V-ATPase inhibitor, can inhibit the migration and invasio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6917
更新日期:2017-11-01 00:00:00
abstract::In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2387
更新日期:2014-10-01 00:00:00
abstract::Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is currently approved in Japan for treatment of breast cancer. However, apart from phase I clinical trials, data regarding Japanese patients are scant. In the present study, the efficacy and safety of nab-paclitaxel therapy were retrospectively analyzed in 22 pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2954
更新日期:2015-04-01 00:00:00
abstract::Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9467
更新日期:2018-11-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6211
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to investigate whether ultrasound combined with microbubbles was able to enhance liposome-mediated transfection of genes into human prostate cancer cells, and to examine the association between autophagy and tumor protein P53 (P53). An MTT assay was used to evaluate cell viability, whi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3946
更新日期:2016-01-01 00:00:00
abstract::Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6235
更新日期:2017-07-01 00:00:00
abstract::It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7651
更新日期:2018-03-01 00:00:00
abstract::The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11799
更新日期:2020-09-01 00:00:00