Actein inhibits cell proliferation and migration and promotes cell apoptosis in human non-small cell lung cancer cells.

abstract：:Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...

journal_title：Oncology letters

authors： Ueno T,Soh J,Hiraki T,Asano H,Ichimura K,Shibamoto K,Gobara H,Kanazawa S,Toyooka S,Miyoshi S

更新日期：2012-02-01 00:00:00

abstract：:Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...

journal_title：Oncology letters

authors： Song T,Yang H,Ho JC,Tang SC,Sze SC,Lao L,Wang Y,Zhang KY

更新日期：2015-06-01 00:00:00

abstract：:Severe hemorrhage following a prostatectomy is a rare and serious complication. A 63-year-old male with severe hemorrhage following radical prostatectomy which led to hypovolemic shock presented at our department and was treated with superselective internal iliac arterial embolization. At 6 months follow-up, the patie...

journal_title：Oncology letters

authors： Cheng S,Xu L,Li G,Chen Y,Hu H,Zhang Z,Ding G

更新日期：2012-09-01 00:00:00

abstract：:Hypoxia is a critical aspect of tumor biology and has been associated with poor prognosis and resistance to traditional therapy. In the present study, differentially expressed genes and microRNAs (miRNAs/miRs) were screened for in the hepatocellular carcinoma (HCC) cell line Huh7 under hypoxic conditions. On the basis...

journal_title：Oncology letters

authors： Hu B,Tang WG,Fan J,Xu Y,Sun HX

更新日期：2018-01-01 00:00:00

abstract：:Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study invest...

journal_title：Oncology letters

authors： Li S,Wang F,Zhai Z,Fu S,Lu J,Zhang H,Guo H,Hu X,Li R,Wang Z,Rodriguez R

更新日期：2017-08-01 00:00:00

abstract：:Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...

journal_title：Oncology letters

authors： Wang J,Deng Q,Jiang YY,Zhang R,Zhu HB,Meng JX,Li YM

更新日期：2019-11-01 00:00:00

abstract：:The transcription factor AP-2 β (TFAP2B) serves an important role in kidney development. MicroRNAs (miRNAs) regulate carcinogenic pathways and have gained increasing attention owing to their association with human clear cell renal cell carcinoma (ccRCC) tumorigenesis. However, whether miRNAs could affect renal cell tu...

journal_title：Oncology letters

authors： Zhu M,Zou L,Lu F,Ye L,Su B,Yang K,Lin M,Fu J,Li Y

更新日期：2020-12-01 00:00:00

abstract：:Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...

journal_title：Oncology letters

authors： Yu B,Liu X,Cao X,Zhang M,Chang H

更新日期：2017-04-01 00:00:00

abstract：:Previous studies have demonstrated a significant difference in clinical characteristics between patients with non-small cell lung cancer (NSCLC) harboring exon 19 deletion (19-del) and an exon point mutation (21-L858R) in EGFR. The present retrospective study aimed to investigate the differential prognosis in patients...

journal_title：Oncology letters

authors： Hong W,Wu Q,Zhang J,Zhou Y

更新日期：2019-10-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00

abstract：:It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore-associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy...

journal_title：Oncology letters

authors： Makita Y,Teratani M,Murata S,Hoashi Y,Matsumoto S,Kawamata Y

更新日期：2018-04-01 00:00:00

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...

journal_title：Oncology letters

authors： Li J,Wang L,Qiu Z,Su Y

更新日期：2019-03-01 00:00:00

abstract：:Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...

journal_title：Oncology letters

authors： Chuthapisith S,Warnnissorn M,Amornpinyokiat N,Pradniwat K,Angsusinha T

更新日期：2013-09-01 00:00:00

abstract：:This study investigated whether microRNA-183 and microRNA-141 in nasopharyngeal carcinoma (NPC) lesions are potential risk factors for poor prognosis. A total of 317 NPC patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2010 to March 2015 were included. Reverse transcripti...

journal_title：Oncology letters

authors： Lian J,Li Y,Yu M

更新日期：2019-01-01 00:00:00

abstract：:Cell migration potency is essential in cancer metastasis and is often regulated by extracellular stimuli. Oral squamous cell carcinoma cell lines include those that are sensitive, as well as resistant, to the effects of the epidermal growth factor receptor (EGFR) inhibitor cetuximab on cell migration. In the present s...

journal_title：Oncology letters

authors： Ohnishi Y,Yasui H,Kakudo K,Nozaki M

更新日期：2017-02-01 00:00:00

abstract：:The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...

journal_title：Oncology letters

authors： Cao F,Li A,Li J,Fang YU,Li F

更新日期：2015-10-01 00:00:00

abstract：:Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...

journal_title：Oncology letters

authors： Iwahashi N,Sakai K,Noguchi T,Yahata T,Toujima S,Nishio K,Ino K

更新日期：2018-11-01 00:00:00

abstract：:The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non-cancerous tissues, and 16 normal liver tissues were collected. ZNF689 exp...

journal_title：Oncology letters

authors： Yi PS,Wu B,Deng DW,Zhang GN,Li JS

更新日期：2018-10-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...

journal_title：Oncology letters

authors： Yang L,Wang Y,Wang H

更新日期：2019-12-01 00:00:00

abstract：:The aim of the current study was to investigate the potential role of microRNA-183-5p (miR-183-5p) in the proliferation, invasion and metastasis of pancreatic cancer, and to identify promising target genes of oncogenic miR-183-5p. Western blotting and quantitative polymerase chain reaction (qPCR) were used to investig...

journal_title：Oncology letters

authors： Miao F,Zhu J,Chen Y,Tang N,Wang X,Li X

更新日期：2016-01-01 00:00:00

abstract：:Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated the functional role of miR-525 in CHS tissues and cells. In the present study, it was discovered that miR-525 levels were decreased in CHS tissues ...

journal_title：Oncology letters

authors： Liu B,Song X,Yan Z,Yang H,Shi Y,Wu J

更新日期：2019-01-01 00:00:00

abstract：:In our previous study, we demonstrated that type II cGMP-dependent protein kinase (PKG II) was expressed at lower levels in different human cancer cell lines and that exogenous PKG II inhibited epidermal growth factor (EGF)-induced MAPK/ERK signaling. In order to investigate its functions further in this signaling pat...

journal_title：Oncology letters

authors： Tao Y,Gu YJ,Cao ZH,Bian XJ,Lan T,Sang JR,Jiang L,Wang Y,Qian H,Chen YC

更新日期：2012-11-01 00:00:00

abstract：:WNT1-inducible-signaling pathway protein-1 (WISP-1) belongs to the family of cysteine rich 61/connective tissue growth factor/nephroblastoma overexpressed matricellular proteins, which are involved in various biological processes, including cell adhesion, proliferation, differentiation, angiogenesis and carcinogenesis...

journal_title：Oncology letters

authors： Jung EK,Kim SA,Yoon TM,Lee KH,Kim HK,Lee DH,Lee JK,Chung IJ,Joo YE,Lim SC

更新日期：2017-08-01 00:00:00

abstract：:A standard therapeutic approach for advanced malignant thymoma has yet to be defined given the rarity of this condition. We present a patient with advanced thymoma, evaluated as inoperable at diagnosis due to multiple serosal metastases. The strong constitution and determination of the patient allowed treatment with s...

journal_title：Oncology letters

authors： Bergonzi M,Orlandoni G,Corbella F,Gobbi PG

更新日期：2011-05-01 00:00:00

abstract：:Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...

journal_title：Oncology letters

authors： Liu M,Xing LQ

更新日期：2017-08-01 00:00:00

abstract：:Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...

journal_title：Oncology letters

authors： Shen A,Ma J,Hu X,Cui X

更新日期：2020-06-01 00:00:00

abstract：:The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...

journal_title：Oncology letters

authors： Xiang L,Dong W,Wang R,Wei J,Qiu G,Cen J,Chen Z,Zheng X,Hu S,Xie X,Cao X,Gu W

更新日期：2014-07-01 00:00:00

abstract：:In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...

journal_title：Oncology letters

authors： Yan Y,Wu Q,Li ZY,Bu ZD,Ji JF

更新日期：2019-03-01 00:00:00

abstract：:The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...

journal_title：Oncology letters

authors： Gu F,Ma Y,Fan Y,Lang R,Ding T,Hao X,Gong Y,Kobayahsi H,Fang Z,Fu L

更新日期：2010-09-01 00:00:00