Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies.

abstract：:In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected i...

journal_title：Oncology letters

authors： Kong LL,Man DM,Wang T,Zhang GA,Cui W

更新日期：2015-12-01 00:00:00

abstract：:Glioblastomas are the most common primary and malignant brain tumors. The standard therapy includes surgery and radiotherapy plus chemotherapy, with additional bevacizumab to block the angiogenesis in tumors. However, the ever-growing tolerance of glioblastomas to chemotherapeutic drugs impairs the clinical outputs of...

journal_title：Oncology letters

authors： Huang H,Song J,Liu Z,Pan L,Xu G

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...

journal_title：Oncology letters

authors： Ichinokawa K,Nakanishi Y,Hida Y,Tsuchikawa T,Kato T,Itoh T,Kaji M,Kaga K,Hirano S

更新日期：2019-07-01 00:00:00

abstract：:The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coeffic...

journal_title：Oncology letters

authors： Shi H,Zhang L,Qu Y,Hou L,Wang L,Zheng M

更新日期：2017-10-01 00:00:00

abstract：:The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...

journal_title：Oncology letters

authors： Wang S,Liu X,Huang J,Zhang Y,Sang C,Li T,Yuan J

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to discuss the antitumor effect of Tegafur combined with Barbadian on S-180 tumor-bearing mice. A murine tumor model was prepared by subcutaneous injection of S-180 sarcoma cells to the armpit of the right limb of healthy female SPF KM mice. The 24 tumor-bearing mice were randomly divided int...

journal_title：Oncology letters

authors： Zhang E,Fu A,Chen W,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...

journal_title：Oncology letters

authors： Chen J,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...

journal_title：Oncology letters

authors： Schcolnik-Cabrera A,Dominguez-Gómez G,Chávez-Blanco A,Ramírez-Yautentzi M,Morales-Bárcenas R,Chávez-Díaz J,Taja-Chayeb L,Dueáas-González A

更新日期：2019-12-01 00:00:00

abstract：:Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...

journal_title：Oncology letters

authors： Sun H,Hu P,Du J,Wang X

更新日期：2018-03-01 00:00:00

abstract：:Significant antitumor activity of Momordica anti-human immunodeficiency virus protein of 30 kDa (MAP30) purified from Momordica charantia has been the subject of previous research. However, the effective mechanism of MAP30 on malignant glioma cells has not yet been clarified. The aim of the present study was to invest...

journal_title：Oncology letters

authors： Jiang Y,Miao J,Wang D,Zhou J,Liu B,Jiao F,Liang J,Wang Y,Fan C,Zhang Q

更新日期：2018-04-01 00:00:00

abstract：:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...

journal_title：Oncology letters

authors： Yan Z,Liu G,Liang M,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...

journal_title：Oncology letters

authors： Al-Muhtaseb SI

更新日期：2014-12-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from Garcinia hanburyi, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties...

journal_title：Oncology letters

authors： Boueroy P,Hahnvajanawong C,Boonmars T,Saensa-Ard S,Anantachoke N,Vaeteewoottacharn K,Reutrakul V

更新日期：2016-12-01 00:00:00

abstract：:Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...

journal_title：Oncology letters

authors： Gong LI,Zhang WD,Mu XR,Han XJ,Yao LI,Zhu SJ,Zhang FQ,Li YH,Zhang W

更新日期：2015-09-01 00:00:00

abstract：:A 56-year-old male patient with locally advanced mucinous rectal cancer underwent neoadjuvant chemoradiotherapy. Follow-up imaging with positron emission tomography-computed tomography (PET-CT) revealed a local response to chemoradiotherapy, whereas diffusion-weighted magnetic resonance imaging (DW-MRI) showed newly p...

journal_title：Oncology letters

authors： Bozkurt M,Okutur K,Aydin K,Namal E,Oztürk A,Balci C,Demir G

更新日期：2012-06-01 00:00:00

abstract：:While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...

journal_title：Oncology letters

authors： Svaton M,Fiala O,Krakorova G,Blazek J,Hurdalkova K,Barinova M,Mukensnabl P,Pesek M

更新日期：2020-08-01 00:00:00

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to assess the feasibility, safety and efficiency of ultrasound-guided percutaneous microwave ablation (MWA) on liver metastases from colon or rectal cancer. Patients who received MWA therapy for liver metastases from colon or rectal cancer between June 2009 and May 2012 were enrolled in the stu...

journal_title：Oncology letters

authors： Wang J,Liang P,Yu J,Yu MA,Liu F,Cheng Z,Yu X

更新日期：2014-07-01 00:00:00

abstract：:Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...

journal_title：Oncology letters

authors： Cui L,Xu L,Wang G,Wen J,Luo L,Zhao H,Chen S,Zheng M,Sun C,Jin X,Yang L

更新日期：2020-10-01 00:00:00

abstract：:Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of...

journal_title：Oncology letters

authors： Li BQ,Huang S,Shao QQ,Sun J,Zhou L,You L,Zhang TP,Liao Q,Guo JC,Zhao YP

更新日期：2017-04-01 00:00:00

abstract：:Long non-coding (lnc)RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1), an lncRNA antisense transcript adjacent to the heart and neural crest derivatives expressed 2 protein (HAND2), inhibits the development of several types of cancer; however, its role in melanoma is currently unknown. In...

journal_title：Oncology letters

authors： Liu P,Du R,Yu X

更新日期：2019-08-01 00:00:00

abstract：:A standard therapeutic approach for advanced malignant thymoma has yet to be defined given the rarity of this condition. We present a patient with advanced thymoma, evaluated as inoperable at diagnosis due to multiple serosal metastases. The strong constitution and determination of the patient allowed treatment with s...

journal_title：Oncology letters

authors： Bergonzi M,Orlandoni G,Corbella F,Gobbi PG

更新日期：2011-05-01 00:00:00

abstract：:A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...

journal_title：Oncology letters

authors： Liu LH,Yang XF

更新日期：2016-06-01 00:00:00

abstract：:The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...

journal_title：Oncology letters

authors： Wang C,Chen L,Huang Y,Li K,Jinye A,Fan T,Zhao R,Xia X,Shen B,Du J,Liu Y

更新日期：2019-02-01 00:00:00

abstract：:The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. Pancreatic carcinoma is one of the most malignant human cancer type...

journal_title：Oncology letters

authors： Zhi D,Zhao X,Dong M,Yan C

更新日期：2017-12-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...

journal_title：Oncology letters

authors： Gao X,Wang M,Zhang Y,Xu Z,Ding J,Tang J

更新日期：2019-09-01 00:00:00

abstract：:Hepatitis B virus × protein (HBx) serves an important role in the pathogenesis of the hepatitis B virus infection. Previous studies have reported that the interaction between HBx and hepatocyte mitochondria is an important factor leading to liver cell injury and apoptosis, ultimately inducing the formation of liver ca...

journal_title：Oncology letters

authors： Ling LR,Zheng DH,Zhang ZY,Xie WH,Huang YH,Chen ZX,Wang XZ,Li D

更新日期：2020-04-01 00:00:00

abstract：:Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...

journal_title：Oncology letters

authors： Chen Q,Zhou Z,Shan L,Zeng H,Hua Y,Cai Z

更新日期：2015-07-01 00:00:00

abstract：:Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...

journal_title：Oncology letters

authors： Chen X,Zhang Y,Wang F,Wang M,Teng W,Lin Y,Han X,Jin F,Xu Y,Cao P,Fang J,Zhu P,Tong C,Liu H

更新日期：2017-11-01 00:00:00