Abstract:
:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesions. However, the efficacy of Ophiopogonin D on human laryngocarcinoma remains to be elucidated. The present study therefore investigated whether the anti-cancer effect of Ophiopogonin D inhibits cell proliferation and induces apoptosis of human laryngocarcinoma. In the present study, it was found that Ophiopogonin D inhibited cell proliferation, promoted cytotoxicity, induced apoptosis and increased caspase-3/9 activity in human laryngocarcinoma cells. Ophiopogonin D significantly suppressed cyclin B1 and matrix metalloproteinase-9 (MMP-9) protein expression, and upregulated p-p38 MAPK protein expression in human laryngocarcinoma cells. Together, these results suggest Ophiopogonin D inhibits cell proliferation and induced apoptosis in human laryngocarcinoma cells through downregulation of cyclin B1 and MMP-9 and upregulation of the p38 MAPK signaling pathway. Therefore, Ophiopogonin D may be a potential therapy for the treatment of human laryngocarcinoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Yan Z,Liu G,Liang M,Xu Ydoi
10.3892/ol.2018.9788subject
Has Abstractpub_date
2019-02-01 00:00:00pages
1877-1882issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-9788journal_volume
17pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Peritoneal metastasis is an important prognostic factor for pancreatic cancer. The present study evaluated the possibility of diagnosing peritoneal metastasis by a photodynamic diagnosis using 5-aminolevulinic acid (5-ALA-PDD). In vitro, protoporphyrin IX (PpIX) accumulation was examined in the AsPC-1-GFP cell line fo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8732
更新日期:2018-07-01 00:00:00
abstract::The present study aimed to investigate the effect of gastrin-releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3240
更新日期:2015-07-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. To the best of our knowledge, the present study was the first to examine ADAM9 expression in vestibular schwannomas (VS) from patients with and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11299
更新日期:2020-03-01 00:00:00
abstract::An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1492
更新日期:2013-10-01 00:00:00
abstract::A standard therapeutic approach for advanced malignant thymoma has yet to be defined given the rarity of this condition. We present a patient with advanced thymoma, evaluated as inoperable at diagnosis due to multiple serosal metastases. The strong constitution and determination of the patient allowed treatment with s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.282
更新日期:2011-05-01 00:00:00
abstract::Anesthetic effect of propofol combined with remifentanil or sevoflurane intravenous anesthesia on patients undergoing radical gastrectomy was evaluated. The clinical data of 516 cancer patients who received radical gastrectomy in the First Bethune Hospital of Jilin University between January 2011 and December 2017 wer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10238
更新日期:2019-06-01 00:00:00
abstract::The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltratin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11750
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1407
更新日期:2013-08-01 00:00:00
abstract::The clinical decisions made when treating patients with metastatic cancer require knowledge of the current tumor extent and response to therapy. For the majority of solid tumors, a response assessment, which is based on imaging, is used to guide these decisions. However, measuring serum protein biomarkers (i.e. tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11192
更新日期:2020-02-01 00:00:00
abstract::The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4568
更新日期:2016-07-01 00:00:00
abstract::Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10647
更新日期:2019-09-01 00:00:00
abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7116
更新日期:2017-12-01 00:00:00
abstract::The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.342
更新日期:2011-09-01 00:00:00
abstract::The LIM domain only protein 2 (LMO2) is a key regulator of hematopoietic stem cell development. Expression of LMO2 has been evaluated in B-cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia; however, information concerning its role in breakpoint cluster region/Abelson murine leukemia viral o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4127
更新日期:2016-03-01 00:00:00
abstract::Human ribosomal protein S3 (hRpS3) is a component of the 40S ribosomal subunit that associated in protein synthesis. hRpS3 has additional ribosomal functions such as DNA repair, transcription, metastasis, and apoptosis via interaction with numerous signaling molecules and has different modifications. Cyclin-dependent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5906
更新日期:2017-05-01 00:00:00
abstract::Delta-like ligand 4 (Dll4)-Notch signaling is important in tumor angiogenesis; however, the prognostic value of D114 detection in patients with clear cell renal cell carcinoma (CCRCC) remains unclear. The present study aimed to determine whether the presence of high Dll4 expression levels was correlated with poor prog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2554
更新日期:2014-12-01 00:00:00
abstract::Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8726
更新日期:2018-07-01 00:00:00
abstract::Local adjuvant treatment of giant cell tumours (GCTs) of the bone with phenol has led to a significant reduction in recurrence rates. In the current study, the optimal phenol concentration and duration of intralesional exposure were evaluated. Specimens of GCTs were exposed to various concentrations of phenol solution...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1244
更新日期:2013-05-01 00:00:00
abstract::The novel synthesis of dibenzofluorene has been achieved by a cyclodehydration method. Several derivatives have also been prepared using this hydrocarbon. These compounds have been tested against a number of cancer cell lines in vitro, and useful selectivity has been observed. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000055
更新日期:2010-03-01 00:00:00
abstract::The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000157
更新日期:2010-09-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00
abstract::T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell l...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5855
更新日期:2017-05-01 00:00:00
abstract::Lung cancer is the most frequent cause of cancer-associated mortality among men and women globally. The skeleton is one of the most common metastatic sites. The majority of patients exhibiting bone metastases are treated using systemic therapy or symptom-based palliative approaches without surgery. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4190
更新日期:2016-03-01 00:00:00
abstract::A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1654
更新日期:2014-01-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00
abstract::Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5125
更新日期:2016-11-01 00:00:00
abstract::The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3082
更新日期:2015-06-01 00:00:00
abstract::Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2665
更新日期:2015-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8441
更新日期:2018-06-01 00:00:00