MicroRNA-183-5p promotes the proliferation, invasion and metastasis of human pancreatic adenocarcinoma cells.

abstract：:Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is a major obstacle for successful chemotherapy. The pres...

journal_title：Oncology letters

authors： Liu B,Li LJ,Gong X,Zhang W,Zhang H,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...

journal_title：Oncology letters

authors： Badr MA,Hassan TH,El-Gerby KM,Lamey ME

更新日期：2013-02-01 00:00:00

abstract：:Colon cancer is the second most common type of cancer in females and the third in males, worldwide. The most common sites of colon cancer metastasis are the regional lymph nodes, liver, lung, bone and brain. In this study, an extremely rare case of colon adenocarcinoma with extensive metastasis to the mediastinal lymp...

journal_title：Oncology letters

authors： El-Halabi MM,Chaaban SA,Meouchy J,Page S,Salyers WJ Jr

更新日期：2014-11-01 00:00:00

abstract：:To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reac...

journal_title：Oncology letters

authors： Xia XM,Jin WY,Shi RZ,Zhang YF,Chen J

更新日期：2010-11-01 00:00:00

abstract：:Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...

journal_title：Oncology letters

authors： Wang Y,Qian H,Wang J

更新日期：2015-12-01 00:00:00

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00

abstract：:Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR...

journal_title：Oncology letters

authors： Zhang X,Li H,Mao M,Wang X,Zheng J,Yang S

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...

journal_title：Oncology letters

authors： Komatsu T,Oizumi Y,Kunieda E,Tamai Y,Akiba T,Kogawa A

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to investigate the function of microRNA-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway was a direct target of microRNA-543. When compared with para...

journal_title：Oncology letters

authors： Xiu D,Wang D,Wang J,Ji F,Zhang W

更新日期：2019-02-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence and mortality rates are increasing worldwide. Mortalin is a highly conserved chaperone protein involved in multiple pathological and physiological processes, including anti-apoptosis, carcinogenesis and metastasis. The Bcl-2 famil...

journal_title：Oncology letters

authors： Kang Q,Zou H,Yang X,Cai JB,Liu LX,Xie N,Wang LM,Li YH,Zhang XW

更新日期：2018-02-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the p...

journal_title：Oncology letters

authors： Dumitrascu MC,Mares C,Petca RC,Sandru F,Popescu RI,Mehedintu C,Petca A

更新日期：2020-12-01 00:00:00

abstract：:The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...

journal_title：Oncology letters

authors： Weng W,Zhang P,Ruan J,Zhang Y,Ba D,Tang Y

更新日期：2020-01-01 00:00:00

abstract：:Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...

journal_title：Oncology letters

authors： Yi S,Chen Y,Wen L,Yang L,Cui G

更新日期：2012-11-01 00:00:00

abstract：:The aim of the present study was to investigate the immunohistochemical expression of cluster of differentiation (CD) 34 and vascular endothelial growth factor (VEGF) in breast cancer tissue, and their prognostic significance. High CD34 expression levels (microvessel density, >15/HPF) were identified in 27.3% (12/44) ...

journal_title：Oncology letters

authors： Chen Z,Xu S,Xu W,Huang J,Zhang GU,Lei L,Shao X,Wang X

更新日期：2015-08-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) participate in the detoxification and elimination of electrophilic carcinogens by conjugating them to glutathione. Previous studies have reported a potential association between GSTM1 polymorphism and the risk of developing nasopharyngeal cancer (NPC). However, those findings remain c...

journal_title：Oncology letters

authors： Zhao Y,Wang Y,Wu X,Wang J,Zhang L,Jia Y,Qi W

更新日期：2016-01-01 00:00:00

abstract：:The present study was performed to quantify tumor neo-vessels, macrophages and fibroblasts in the tumor microenvironment of hepatocellular carcinoma (HCC) and explore the prognostic factors of HCC. The distribution of tumor neo-vessels, macrophages and fibroblasts was quantified by immunohistochemistry and inverted mi...

journal_title：Oncology letters

authors： Fang M,Yuan J,Chen M,Sun Z,Liu L,Cheng G,Ying H,Yang S,Chen M

更新日期：2018-04-01 00:00:00

abstract：:Pendred syndrome is a rare genetic disease that causes a disturbance in thyroid hormone synthesis, which results in thyroid dysfunction and the development of goiter and sensorineural deafness. The present report describes the case of a young euthyroid male, who developed a large goiter and hearing impairment, despite...

journal_title：Oncology letters

authors： Hu EW,Liu LB,Jiang RY,He XH

更新日期：2014-11-01 00:00:00

abstract：:Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...

journal_title：Oncology letters

authors： Takesue T,Kawakubo H,Hayashida T,Tsutsui M,Miyao K,Fukuda K,Nakamura R,Takahashi T,Wada N,Takeuchi H,Kitagawa Y

更新日期：2017-10-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...

journal_title：Oncology letters

authors： Xie CQ,Zhou P,Zuo J,Li X,Chen Y,Chen JW

更新日期：2016-11-01 00:00:00

abstract：:Intramuscular myxoma (IM) is a benign intramuscular neoplasm composed of fibroblasts and abundant myxoid stroma. IMs most commonly affect larger skeletal muscles, while those affecting the oral and maxillofacial regions are rare, with a small number of documented cases in the available literature. The aim of the prese...

journal_title：Oncology letters

authors： Li G,Jiang W,Li W,Li J

更新日期：2014-05-01 00:00:00

abstract：:Transcription factors encoded by HOX genes are vital in the determination of cell fate and identity during embryonic development. In certain malignancies, HOX genes also behave as oncogenes. The present study demonstrated suppression of the invasive tendency of glioblastoma multiforme U-118 and U-138 cells by the intr...

journal_title：Oncology letters

authors： Guo YB,Shao YM,Chen J,Xu SB,Zhang XD,Wang MR,Liu HY

更新日期：2016-01-01 00:00:00

abstract：:Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...

journal_title：Oncology letters

authors： Shen J,Wang Q,Wang J,Su GH,Wang J,Guo SH,Liu YA,Wu Z,Liu RF,Li X,Guo XJ,Cao J,Zhang YH,Wang ZY

更新日期：2015-10-01 00:00:00

abstract：:Clear cell sarcoma of soft tissues is a very rare, malignant soft tissue tumor that usually arises in the extremities, with a predilection for the lower limbs. This report presents a 45-year-old male with a painless mass in the right lumbar region for one year. Magnetic resonance imaging showed a 3.6×3.2×1.5-cm soft t...

journal_title：Oncology letters

authors： Yang XL,Lu SJ,Xue J,Wu YF,Shi JL

更新日期：2014-10-01 00:00:00

abstract：:Fibroadenomas are a type of benign tumor that occur in young women below the age of 35 years old. The tumors are the second most common type of tumor after fibrocystic disease. The chance of carcinoma arising in a fibroadenoma is extremely low. To date, <130 such cases have been reported. Previous studies have reporte...

journal_title：Oncology letters

authors： Zheng H,Chen J,Wu X,Jin L,Qi C

更新日期：2015-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2017.6254.]. ...

journal_title：Oncology letters

authors： Sato S,Kato T,Abe K,Hanaoka T,Yano Y,Kurosaki A,Yasuda M,Sekino T,Fujiwara K,Hasegawa K

更新日期：2017-10-01 00:00:00

abstract：:Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was t...

journal_title：Oncology letters

authors： Zhang Q,Luo Q,Yuan X,Chai L,Li D,Liu J,Lv Z

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to analyze potential therapy targets for prostate cancer using integrated analysis of two gene expression profiles. First, gene expression profiles GSE38241 and GSE3933 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between prostate can...

journal_title：Oncology letters

authors： Zhao R,Wang Y,Zhang M,Gu X,Wang W,Tan J,Wei X,Jin N

更新日期：2017-11-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogene...

journal_title：Oncology letters

authors： Yang Y,Shen Z,Yan Y,Wang B,Zhang J,Shen C,Li T,Ye C,Gao Z,Peng G,Ye Y,Jiang K,Wang S

更新日期：2017-05-01 00:00:00

abstract：:Hepatocellular carcinoma is a serious public health problem in China. The mortality rate associated with the majority of cancer types has decreased as a result of targeted therapy. However, the mortality rates associated with hepatocellular carcinoma have not improved; therefore, the identification of new molecular ta...

journal_title：Oncology letters

authors： Yuan B,Bo W,Feng X,Hu Y,Zeng J

更新日期：2020-12-01 00:00:00

abstract：:The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probe...

journal_title：Oncology letters

authors： Ke Z,Lai Y,Ma X,Lil S,Huang W

更新日期：2014-02-01 00:00:00