Abstract:
:To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reaction. Our results using 31 NSCLC patient samples showed that 67.74% had a low let-7 expression (P<0.05), 64.52% had a high K-ras expression (P<0.05), and a significant correlation was observed between let-7 and K-ras gene expression (r=-0.6336) in tumor tissues. Patients with a low let-7 expression had a significantly shorter survival than those with a moderate let-7 expression (P<0.05). Patients with a high K-ras expression also had a significantly shorter survival than those with a moderate K-ras expression (P<0.05). In conclusion, a low expression of let-7 and a high expression of K-ras are correlated with the pathogenesis and prognosis of NSCLC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xia XM,Jin WY,Shi RZ,Zhang YF,Chen Jdoi
10.3892/ol.2010.164subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1045-1047issue
6eissn
1792-1074issn
1792-1082pii
ol-01-06-1045journal_volume
1pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5706
更新日期:2017-04-01 00:00:00
abstract::The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5-7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells with AnnexinV/propidi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10341
更新日期:2019-07-01 00:00:00
abstract::Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.790
更新日期:2012-10-01 00:00:00
abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to examine the effects of compound Radix Sophorae Flavescentis on the proliferation of esophageal carcinoma TE-8 cells and to elucidate the mechanisms involved. For this purpose, we incubated TE-8 cells in medium containing various concentrations (0, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4 and 0.8...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3607
更新日期:2015-10-01 00:00:00
abstract::MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8443
更新日期:2018-06-01 00:00:00
abstract::Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11363
更新日期:2020-04-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common and malignant type of glioma, with a poor prognosis for patients. The survival time of patients varies greatly due to the complexity of the human genome, which harbors diverse oncogenic drivers. In order to identify the specific driving factors, 325 glioma samples from ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10296
更新日期:2019-07-01 00:00:00
abstract::Ductal adenocarcinoma of the prostate (DAP) is a rare variant of prostate cancer, and has poorly-identified clinical characteristics. Few cases have been previously reported in Chinese males and DAP is more commonly reported in Caucasian males over 70-years of age. In the present study, a 55-year-old Chinese male pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4098
更新日期:2016-02-01 00:00:00
abstract::Survivin is expressed in the nucleus and/or cytoplasm of various malignant cells. Nuclear survivin is critical for the completion of mitosis, while cytoplasmic survivin functions as an inhibitor of apoptosis. The expression of survivin has been reported to be associated with the aggressiveness of certain types of canc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3374
更新日期:2015-09-01 00:00:00
abstract::Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient receiv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5555
更新日期:2017-03-01 00:00:00
abstract::The incidence of intussusception is low in adults, particularly in the descending colon, due to the anatomical attachment of the descending colon to the retroperitoneum. Signet ring cell histology represents ~1% of colon adenocarcinomas and is associated with young patients and a poor clinical outcome. The present stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2805
更新日期:2015-03-01 00:00:00
abstract::Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2059
更新日期:2014-07-01 00:00:00
abstract::Changes in the expression of regulator of G protein signaling 2 (RGS2) are involved in the genesis and development of a number of malignancies. However, the association between changes in the expression of RGS2 and breast invasive carcinoma of no special type (BIC-NST) remains unknown. The present study found that, in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7351
更新日期:2018-01-01 00:00:00
abstract::Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6195
更新日期:2017-07-01 00:00:00
abstract::The present study describes the case of a 48-year-old man who was diagnosed with lung adenocarcinoma with an epidermal growth factor receptor (EGFR) 21 L858R mutation. The patient received surgery and adjuvant chemotherapy. When multiple lung metastases appeared, icotinib was administered. Following resistance to icot...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8040
更新日期:2018-04-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10808
更新日期:2019-11-01 00:00:00
abstract::Adenocarcinoma is one of the most serious diseases that threaten human health. Numerous studies have investigated adenocarcinoma and have obtained a considerable amount of data regarding genes and microRNA (miRNA) in adenocarcinoma. However, studies have only focused on one or a small number of genes and miRNAs, and t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3676
更新日期:2015-11-01 00:00:00
abstract::Although a combination of platinum- and taxane-based chemotherapy is recommended for at least 70% patients with ovarian cancer as treatment subsequent to surgery, the initial response to the chemotherapy is not durable and tumors become resistant. Histone deacetylase and proteasome inhibitors are novel therapeutic age...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6032
更新日期:2017-06-01 00:00:00
abstract::The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB....
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6557
更新日期:2017-09-01 00:00:00
abstract::The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2971
更新日期:2015-04-01 00:00:00
abstract::Determining the resectable region and volume of the liver prior to anatomical resection is important. The synapse Vincent (SV) system is the current method for surgical liver resection that relies on the surgeon's individual experience and skill. Additionally, in cases involving abnormal liver function, the resectable...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11006
更新日期:2019-12-01 00:00:00
abstract::Extraskeletal myxoid chondrosarcoma (EMC) is a relatively rare but well-defined neoplasm. This report describes two patients, one with EMC of the buttock and one with EMC of the knee. The two cases presented with large lobed masses and long T1 and T2 signaling identified by magnetic resonance imaging (MRI). An enhance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1884
更新日期:2014-04-01 00:00:00
abstract::Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10530
更新日期:2019-09-01 00:00:00
abstract::Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.531
更新日期:2012-03-01 00:00:00
abstract::The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3775
更新日期:2015-12-01 00:00:00
abstract::Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9202
更新日期:2018-10-01 00:00:00
abstract::Breast cancer is the most common malignant tumor in women in the majority of countries, such as China, Britain and Australia, and its morbidity and mortality rates remain very high. Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) >200 nucleotides in length that lack open reading frames. LncRNA H19 is a tra...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.11093
更新日期:2020-01-01 00:00:00
abstract::Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.918
更新日期:2012-12-01 00:00:00
abstract::Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9757
更新日期:2019-02-01 00:00:00