Metaplastic carcinoma of the breast with transformation from adenosquamous carcinoma to osteosarcomatoid and spindle cell morphology.

abstract：:Acute myeloid leukemia (AML) is a highly heterogeneous disease that remains untreatable. MicroRNAs (miRNAs or miRs) play important roles in the pathogenesis of leukemia. miR-21 is highly expressed in multiple types of human cancer and displays oncogenic activities; however, the clinical significance of miR-21 in AML r...

journal_title：Oncology letters

authors： Zhang L,Yu L,Liu Y,Wang S,Hou Z,Zhou J

更新日期：2021-02-01 00:00:00

abstract：:The monolocular cystic formation associated with gallbladder carcinoma is an extremely rare condition. A 79-year-old female suffering from upper abdominal pain and distention was admitted to our hospital. Ultrasonography and computed tomography revealed a monolocular cyst with an irregular wall thickness of 15 cm in d...

journal_title：Oncology letters

authors： Hiraki M,Yakushiji H,Hashiguchi K,Harada S,Kohya N,Kai K,Yamaguchi K,Mori D,Irie K,Tokunaga O,Noshiro H,Miyazaki K

更新日期：2010-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common malignancy of the head and neck. The aim of the present study was to conduct an integrated bioinformatics analysis of differentially expressed genes (DEGs) and to explore the molecular mechanisms of NPC. Two profiling datasets, GSE12452 and GSE34573, were downloaded from the ...

journal_title：Oncology letters

authors： Zou Z,Gan S,Liu S,Li R,Huang J

更新日期：2019-07-01 00:00:00

abstract：:Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide. In the present study, a prostate SFT case, which was initially misdiagnosed as benign pros...

journal_title：Oncology letters

authors： Yang W,Sun F,Liu H,Wang G,Shi P,Shao Z,Guo F

更新日期：2015-09-01 00:00:00

abstract：:Over the latest decade, the role of microRNAs (miRNAs/miRs) has received more attention. miRNAs are small non-coding RNAs that may serve a role as oncogenes or tumor suppressor genes. Certain miRNAs regulate the apoptosis pathway by influencing pro- or anti-apoptotic genes. We hypothesized that increases in the expres...

journal_title：Oncology letters

authors： Ostadrahimi S,Fayaz S,Parvizhamidi M,Abedi-Valugerdi M,Hassan M,Kadivar M,Teimoori-Toolabi L,Asgari M,Shahrokh H,Abolhasani M,Mahdian R,Fard-Esfahani P

更新日期：2018-05-01 00:00:00

abstract：:Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...

journal_title：Oncology letters

authors： Matsuda Y,Fujii Y,Matsukawa M,Ishiwata T,Nishimura M,Arai T

更新日期：2019-10-01 00:00:00

abstract：:Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...

journal_title：Oncology letters

authors： Jiang L,Liu M,Cai X,Xie L,She F,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:Although hepatocellular carcinoma (HCC) is associated with poor prognosis worldwide, the molecular mechanisms underlying the carcinogenesis and progression of this disease remain unclear. Several tumor characteristics have previously been demonstrated to be prognostic factors of survival following hepatic resection, o...

journal_title：Oncology letters

authors： Inokawa Y,Inaoka K,Sonohara F,Hayashi M,Kanda M,Nomoto S

更新日期：2016-11-01 00:00:00

abstract：:MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...

journal_title：Oncology letters

authors： Yin J,Wang M,Jin C,Qi Q

更新日期：2014-02-01 00:00:00

abstract：:Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine-platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 201...

journal_title：Oncology letters

authors： Dano D,Delteil C,Boissier R,Delaporte V,Habert P,Salas S,Duffaud F,Deville JL

更新日期：2019-03-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell ...

journal_title：Oncology letters

authors： Kita H,Okamoto K,Kushima R,Kawauchi A,Chano T

更新日期：2015-08-01 00:00:00

abstract：:Phospholipase C (PLC) is a membrane-associated enzyme that regulates several cellular behaviors including cell motility, growth, transformation and differentiation. PLC is involved in cancer migration, invasion and drug resistance. However, the expression status and prognostic role of PLCB4 in acute myeloid leukemia (...

journal_title：Oncology letters

authors： Wu S,Zhang W,Shen D,Lu J,Zhao L

更新日期：2019-12-01 00:00:00

abstract：:The purpose of the present study was to evaluate the recent trend of diagnosing appendiceal diseases through the analysis of appendectomy materials, stressing the importance of their pathological examination. A clinicopathological assessment of patients undergoing an appendectomy was conducted, based on the pathologic...

journal_title：Oncology letters

authors： Tajima T,Tajiri T,Mukai M,Sugiyama T,Hasegawa S,Yamamoto S,Sadahiro S,Shimada H,Makuuchi H

更新日期：2018-05-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, including head and neck squamous cell carcinoma (HNSCC). Previously, TGFβ ligands were al...

journal_title：Oncology letters

authors： Bae WJ,Lee SH,Rho YS,Koo BS,Lim YC

更新日期：2016-12-01 00:00:00

abstract：:The transcription factor AP-2 β (TFAP2B) serves an important role in kidney development. MicroRNAs (miRNAs) regulate carcinogenic pathways and have gained increasing attention owing to their association with human clear cell renal cell carcinoma (ccRCC) tumorigenesis. However, whether miRNAs could affect renal cell tu...

journal_title：Oncology letters

authors： Zhu M,Zou L,Lu F,Ye L,Su B,Yang K,Lin M,Fu J,Li Y

更新日期：2020-12-01 00:00:00

abstract：:There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (U...

journal_title：Oncology letters

authors： Hartmann S,Brisam M,Rauthe S,Driemel O,Brands RC,Rosenwald A,Kübler AC,Müller-Richter UD

更新日期：2016-10-01 00:00:00

abstract：:Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients ...

journal_title：Oncology letters

authors： Zhu G,Xiao D,Sun P

更新日期：2016-04-01 00:00:00

abstract：:Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human e...

journal_title：Oncology letters

authors： Teng C,Li LI,Shen W,Li J,Liu Y,Jiang Q,Xin T,Huang D,Song X,Lv Y,Jin Y

更新日期：2015-08-01 00:00:00

abstract：:Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...

journal_title：Oncology letters

authors： Ma J,Liang L,Liu H

更新日期：2012-09-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analys...

journal_title：Oncology letters

authors： Liu W,Liang Y,Bian C,Jiang L,Zheng G,Dong J

更新日期：2018-01-01 00:00:00

abstract：:Aberrant promoter methylation of tumor relevant genes frequently occurs in early steps of carcinogenesis and during tumor progression. Epigenetic alterations could be used as potential biomarkers for early detection and for prediction of prognosis and therapy response in lung cancer. The present study quantitatively a...

journal_title：Oncology letters

authors： Duppel U,Woenckhaus M,Schulz C,Merk J,Dietmaier W

更新日期：2016-10-01 00:00:00

abstract：:The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...

journal_title：Oncology letters

authors： Zhao Y,Jiang H,Gu M,Zu C,Zheng X

更新日期：2020-11-01 00:00:00

abstract：:The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vit...

journal_title：Oncology letters

authors： Jiao H,Zeng L,Zhang J,Yang S,Lou W

更新日期：2020-03-01 00:00:00

abstract：:Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...

journal_title：Oncology letters

authors： Guan N,Wang R,Feng X,Li C,Guo W

更新日期：2020-09-01 00:00:00

abstract：:In the present study, the effect of immunophenotyping on the prognoses of patients with multiple myeloma (MM) treated with bortezomib plus dexamethasone was investigated. The study involved 46 patients with MM, and analyzed the prognostic significance of the expression of cluster of differentiation (CD)45, CD56 and ma...

journal_title：Oncology letters

authors： Iriyama N,Miura K,Hatta Y,Kobayashi S,Uchino Y,Kurita D,Sakagami H,Takahashi H,Sakagami M,Kobayashi Y,Nakagawa M,Ohtake S,Iizuka Y,Takei M

更新日期：2017-05-01 00:00:00

abstract：:The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...

journal_title：Oncology letters

authors： Sugiyama T,Iwaizumi M,Kaneko M,Tani S,Yamade M,Hamaya Y,Furuta T,Miyajima H,Osawa S,Baba S,Maekawa M,Sugimoto K

更新日期：2020-09-01 00:00:00

abstract：:Docking protein 2 (Dok2) and Ras p21 protein activator 1 (RASA1) are tumor suppressors which have been identified in numerous solid tumors; however, the association between their expression in breast cancer and patient prognosis remains unclear. A total of 285 consecutive patients diagnosed histopathologically with br...

journal_title：Oncology letters

authors： Huang J,Peng X,Zhang K,Li C,Su B,Zhang Y,Yu W

更新日期：2017-11-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...

journal_title：Oncology letters

authors： He J,Mu M,Luo Y,Wang H,Ma H,Guo S,Fang Q,Qian Z,Lu H,Song C

更新日期：2019-03-01 00:00:00

abstract：:The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...

journal_title：Oncology letters

authors： Yin SP,Gao Y,Xie XS,Xu DD,Riabov V,Du WD

更新日期：2020-03-01 00:00:00