Abstract:
:The aim of the present study was to obtain comprehensive microRNA (miRNA) profiles of type I [Ishikawa (ISK)] and type II (HEC-1B) human endometrial adenocarcinoma cell lines, utilizing the latest high-throughput sequencing techniques. RNA was extracted from ISK and HEC-1B cell lines. Sequencing results were obtained from a next-generation sequencing platform. Using the miRBase database and a series of software pipelines, miRNA expression was analyzed in the ISK and HEC-1B cell lines. It was revealed that the type and quantity of miRNAs in the two cell types varied significantly; 34 miRNAs were upregulated and 105 miRNAs were downregulated in HEC-1B cells compared with those of ISK cells. Furthermore, it was observed that the expression pattern of the miRNA (miR)-17-92 cluster differed between the two cell types, and the expression levels of the miR-200 family in ISK cells were markedly increased compared with those of HEC-1B cells. The present study therefore identified potential novel biomarkers, which may be useful in the differentiation between type I and type II endometrial cancer, and also revealed miRNA alterations that may be associated with endometrial cancer and its underlying pathogenic mechanisms.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Lu J,Zhang X,Zhang R,Ge Qdoi
10.3892/ol.2015.3776subject
Has Abstractpub_date
2015-12-01 00:00:00pages
3457-3465issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-3776journal_volume
10pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9060
更新日期:2018-09-01 00:00:00
abstract::Primary hemangioendotheliomas (HEs) of the spleen are rare, low-grade borderline-malignant vascular tumors. To date, only a few splenic HE cases have been reported in adults. In infants, one 9-year-old male patient has previously been reported, and the patient succumbed to the disease shortly following surgery. Curren...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2693
更新日期:2015-01-01 00:00:00
abstract::Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6699
更新日期:2017-10-01 00:00:00
abstract::The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8643
更新日期:2018-07-01 00:00:00
abstract::Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6195
更新日期:2017-07-01 00:00:00
abstract::Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5410
更新日期:2017-01-01 00:00:00
abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10415
更新日期:2019-08-01 00:00:00
abstract::Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6256
更新日期:2017-07-01 00:00:00
abstract::Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2136
更新日期:2014-07-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1929
更新日期:2014-05-01 00:00:00
abstract::The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2626
更新日期:2015-01-01 00:00:00
abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11465
更新日期:2020-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5466
更新日期:2017-02-01 00:00:00
abstract::The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5406
更新日期:2017-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative com...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6353
更新日期:2017-08-01 00:00:00
abstract::The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3874
更新日期:2016-01-01 00:00:00
abstract::Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11952
更新日期:2020-10-01 00:00:00
abstract::Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6508
更新日期:2017-09-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9200
更新日期:2018-10-01 00:00:00
abstract::The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1844
更新日期:2014-04-01 00:00:00
abstract::The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltratin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11750
更新日期:2020-08-01 00:00:00
abstract::The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultras...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8122
更新日期:2018-05-01 00:00:00
abstract::The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2419
更新日期:2014-10-01 00:00:00
abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11310
更新日期:2020-03-01 00:00:00
abstract::Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated resto...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8661
更新日期:2018-07-01 00:00:00
abstract::Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4096
更新日期:2016-02-01 00:00:00
abstract::When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5240
更新日期:2016-12-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00