MicroRNA heterogeneity in endometrial cancer cell lines revealed by deep sequencing.

Abstract:

:The aim of the present study was to obtain comprehensive microRNA (miRNA) profiles of type I [Ishikawa (ISK)] and type II (HEC-1B) human endometrial adenocarcinoma cell lines, utilizing the latest high-throughput sequencing techniques. RNA was extracted from ISK and HEC-1B cell lines. Sequencing results were obtained from a next-generation sequencing platform. Using the miRBase database and a series of software pipelines, miRNA expression was analyzed in the ISK and HEC-1B cell lines. It was revealed that the type and quantity of miRNAs in the two cell types varied significantly; 34 miRNAs were upregulated and 105 miRNAs were downregulated in HEC-1B cells compared with those of ISK cells. Furthermore, it was observed that the expression pattern of the miRNA (miR)-17-92 cluster differed between the two cell types, and the expression levels of the miR-200 family in ISK cells were markedly increased compared with those of HEC-1B cells. The present study therefore identified potential novel biomarkers, which may be useful in the differentiation between type I and type II endometrial cancer, and also revealed miRNA alterations that may be associated with endometrial cancer and its underlying pathogenic mechanisms.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Lu J,Zhang X,Zhang R,Ge Q

doi

10.3892/ol.2015.3776

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

3457-3465

issue

6

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-3776

journal_volume

10

pub_type

杂志文章
  • Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9060

    authors: Wang Z,Fu H,Li W

    更新日期:2018-09-01 00:00:00

  • Hemangioendothelioma arising from the spleen: A case report and literature review.

    abstract::Primary hemangioendotheliomas (HEs) of the spleen are rare, low-grade borderline-malignant vascular tumors. To date, only a few splenic HE cases have been reported in adults. In infants, one 9-year-old male patient has previously been reported, and the patient succumbed to the disease shortly following surgery. Curren...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2693

    authors: Wang Z,Zhang L,Zhang B,Mu D,Cui K,Li S

    更新日期:2015-01-01 00:00:00

  • Downregulation of cytochrome c oxidase 1 induced radioresistance in esophageal squamous cell carcinoma.

    abstract::Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another locati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6699

    authors: Takesue T,Kawakubo H,Hayashida T,Tsutsui M,Miyao K,Fukuda K,Nakamura R,Takahashi T,Wada N,Takeuchi H,Kitagawa Y

    更新日期:2017-10-01 00:00:00

  • Restoration of microRNA-130b expression suppresses osteosarcoma cell malignant behavior in vitro.

    abstract::The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8643

    authors: Wu Y,Sun W,Kong Y,Liu B,Zeng M,Wang W

    更新日期:2018-07-01 00:00:00

  • Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed the proliferation of CT26 mouse colon cancer cells.

    abstract::Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6195

    authors: Kadochi Y,Mori S,Fujiwara-Tani R,Luo Y,Nishiguchi Y,Kishi S,Fujii K,Ohmori H,Kuniyasu H

    更新日期:2017-07-01 00:00:00

  • Enhanced expression of hydroxylated ceramide in well-differentiated endometrial adenocarcinoma.

    abstract::Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5410

    authors: Tajima T,Miyazawa M,Hayashi M,Asai S,Ikeda M,Shida M,Hirasawa T,Iwamori M,Mikami M

    更新日期:2017-01-01 00:00:00

  • CXCL12 is associated with FoxP3+ tumor-infiltrating lymphocytes and affects the survival of patients with oral squamous cell carcinoma.

    abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10415

    authors: Zhang B,Wu C,Zhang Z,Yan K,Li C,Li Y,Li L

    更新日期:2019-08-01 00:00:00

  • Hyperthermia and radiation reduce the toxic side-effects of bufadienolides for cancer therapy.

    abstract::Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6256

    authors: Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

    更新日期:2017-07-01 00:00:00

  • Preventive effects of the angiotensin-converting enzyme inhibitor, captopril, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats.

    abstract::Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2136

    authors: Kochi T,Shimizu M,Ohno T,Baba A,Sumi T,Kubota M,Shirakami Y,Tsurumi H,Tanaka T,Moriwaki H

    更新日期:2014-07-01 00:00:00

  • Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum.

    abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8863

    authors: Xu Y,Wang Z,Bi Y,Duan Z,Yue X

    更新日期:2018-08-01 00:00:00

  • BRCA1 regulates insulin-like growth factor 1 receptor levels in ovarian cancer.

    abstract::Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1929

    authors: Liu B,Li D,Guan YF

    更新日期:2014-05-01 00:00:00

  • Characterization of uncommon portosystemic collateral circulations in patients with hepatic cirrhosis.

    abstract::The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and el...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2626

    authors: Wu Q,Shen L,Chu J,Ma X,Jin B,Meng F,Chen J,Wang Y,Wu L,Han J,Zhang W,Ma W,Wang H,Li H

    更新日期:2015-01-01 00:00:00

  • SET and MYND domain-containing protein 3 inhibits tumor cell sensitivity to cisplatin.

    abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11465

    authors: Wang L,Xu ML,Wang C,Dong QQ,Miao Z,Chen XY,Wang N,He HP,Zhang TC,Luo XG

    更新日期:2020-05-01 00:00:00

  • Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells.

    abstract::Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5466

    authors: Huang Z,Zhang N,Li W,Cao J,Zhang L,Chen Y

    更新日期:2017-02-01 00:00:00

  • Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells.

    abstract::The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5406

    authors: Cui L,Song J,Wu L,Cheng L,Chen A,Wang Y,Huang Y,Huang L

    更新日期:2017-01-01 00:00:00

  • Identification of long non-coding RNA CCAT1 as an oncogene in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8969

    authors: Dong Y,Yuan H,Jin G

    更新日期:2018-08-01 00:00:00

  • Characterization of the aminopyridine derivative KRC-180 as a JAK2 inhibitor.

    abstract::Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative com...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6353

    authors: Yoon KB,Cho SY,An SJ,Park KR,Lee HJ,Yoon HS,Lee SM,Kim YC,Han SY

    更新日期:2017-08-01 00:00:00

  • Evaluation of contrast-enhanced ultrasonography for hepatocellular carcinoma prior to and following stereotactic body radiation therapy using the CyberKnife® system: A preliminary report.

    abstract::The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3874

    authors: Shiozawa K,Watanabe M,Ikehara T,Kobayashi K,Ochi Y,Suzuki Y,Fuchinoue K,Yoneda M,Kenmochi T,Okubo Y,Mori T,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

    更新日期:2016-01-01 00:00:00

  • Gamma-irradiation degraded sulfated polysaccharide from a new red algal strain Pyropia yezoensis Sookwawon 104 with in vitro antiproliferative activity.

    abstract::Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11952

    authors: He D,Yan L,Ma X,Cheng Y,Wu S,Zuo J,Park EJ,Liu J,Wu M,Choi JI,Tong H

    更新日期:2020-10-01 00:00:00

  • Overexpression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein in cervical cancer and correlation with squamous cell carcinoma antigen.

    abstract::Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6508

    authors: Wang X,Jiang Y,Yuan M,Chen C,Wang K,Zhang Q,Zuo Y,Ren S

    更新日期:2017-09-01 00:00:00

  • Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor.

    abstract::Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9200

    authors: Liu Y,Liang Y,Li M,Liu D,Tang J,Yang W,Tong D,Jin X

    更新日期:2018-10-01 00:00:00

  • Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature.

    abstract::The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1844

    authors: Chen Z,Xiao HE,Ramchandra P,Huang HJ

    更新日期:2014-04-01 00:00:00

  • Prognostic value of immune cell infiltration in bladder cancer: A gene expression-based study.

    abstract::The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltratin...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11750

    authors: Wang Y,Ba HJ,Liu ZC,Deng XB,Zhou M

    更新日期:2020-08-01 00:00:00

  • Diagnosis and treatment of submucous myoma of the uterus with interventional ultrasound.

    abstract::The value of interventional ultrasound in the diagnosis and treatment of submucous myoma of the uterus was assessed to study the ultrasonographic features of modified sonohysterography for submucous polyp of uterus. A total of 25 patients diagnosed preliminarily as submucous myoma of the uterus via conventional ultras...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8122

    authors: Liang B,Xie YG,Xu XP,Hu CH

    更新日期:2018-05-01 00:00:00

  • In vitro stimulation of calcium overload and apoptosis by sonodynamic therapy combined with hematoporphyrin monomethyl ether in C6 glioma cells.

    abstract::The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2419

    authors: Dai S,Xu C,Tian Y,Cheng W,Li B

    更新日期:2014-10-01 00:00:00

  • Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival.

    abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11310

    authors: Yin SP,Gao Y,Xie XS,Xu DD,Riabov V,Du WD

    更新日期:2020-03-01 00:00:00

  • Advanced choroidal melanoma with a desirable aesthetic outcome after enucleation: A case report.

    abstract::Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated resto...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8661

    authors: Terzidou C,Trivli A,Dalianis G,Apessou D,Spandidos DA,Goulielmos GN

    更新日期:2018-07-01 00:00:00

  • A modified method for the culture of naturally HPV-infected high-grade cervical intraepithelial neoplasia keratinocytes from human neoplastic cervical biopsies.

    abstract::Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4096

    authors: Liu YZ,Wang TT,Zhang YZ

    更新日期:2016-02-01 00:00:00

  • Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue.

    abstract::When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic pre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5240

    authors: Sonohara F,Inokawa Y,Hishida M,Kanda M,Nishikawa Y,Yamada S,Fujii T,Sugimoto H,Kodera Y,Nomoto S

    更新日期:2016-12-01 00:00:00

  • Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A.

    abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11336

    authors: Dong Y,Li Y,Liu R,Li Y,Zhang H,Liu H,Chen J

    更新日期:2020-03-01 00:00:00