Abstract:
:The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and immunohistochemical staining were performed to measure serum folate levels and CADM1 protein expression, respectively. The results demonstrated that CADM1 expression in LSCC specimens was significantly lower than in adjacent normal tissues (χ2=28.229, P<0.001), which was associated with histological differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of serum folate in patients with LSCC were significantly lower than those observed in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present study determined that decreased CADM1 protein expression and low levels of serum folate were correlated with an increased severity of LSCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Chang H,Ma M,Ma R,Zhang C,Zeng W,Xing LQdoi
10.3892/ol.2016.5264subject
Has Abstractpub_date
2016-12-01 00:00:00pages
4510-4514issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-5264journal_volume
12pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Pristimerin is an active compound isolated from the traditional Chinese herbs Celastraceae and Hippocrateaceae. It has been reported to exert antitumor effects under experimental and clinical conditions; however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been iden...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9903
更新日期:2019-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4687
更新日期:2016-08-01 00:00:00
abstract::Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12275
更新日期:2021-01-01 00:00:00
abstract::Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radio-therapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstrated in vivo. This case report describes a 35-year-old male who s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1247
更新日期:2013-05-01 00:00:00
abstract::Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5832
更新日期:2017-05-01 00:00:00
abstract::Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8368
更新日期:2018-06-01 00:00:00
abstract::A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4760
更新日期:2016-08-01 00:00:00
abstract::The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10293
更新日期:2019-07-01 00:00:00
abstract::Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidenc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1555
更新日期:2013-11-01 00:00:00
abstract::The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5673
更新日期:2017-03-01 00:00:00
abstract::Laparoscopic partial nephrectomy has recently emerged as a minimally invasive treatment for small- to moderate-sized renal tumors. Renal artery pseudoaneurysms (RAPs) have been well-reported in patients with renal trauma or who have undergone percutaneous urological procedures, including biopsy, nephrostomy and percut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2045
更新日期:2014-06-01 00:00:00
abstract::This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11662
更新日期:2020-08-01 00:00:00
abstract::Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11938
更新日期:2020-10-01 00:00:00
abstract::Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3157
更新日期:2015-07-01 00:00:00
abstract::MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8557
更新日期:2018-06-01 00:00:00
abstract::Heterogeneous radiological responses (HRRs) among tumor lesions are usually observed following chemotherapy or radiation treatment in cancer patients. When HRR is observed after chemotherapy or radiation treatment, a change in anticancer treatment is recommended due to the clinically high suspicion of resistance in th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3709
更新日期:2015-11-01 00:00:00
abstract::Approximately 34-86% of neoplasms of the salivary glands are located in the parotid gland and parotidectomy is the first-line treatment for parotid gland tumors. Frey syndrome and cosmetic deformity are common complications experienced by patients following parotidectomy and the sternocleidomastoid muscle flap (SCMF) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1179
更新日期:2013-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12091
更新日期:2020-11-01 00:00:00
abstract::Delta-like ligand 4 (Dll4)-Notch signaling is important in tumor angiogenesis; however, the prognostic value of D114 detection in patients with clear cell renal cell carcinoma (CCRCC) remains unclear. The present study aimed to determine whether the presence of high Dll4 expression levels was correlated with poor prog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2554
更新日期:2014-12-01 00:00:00
abstract::Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5126
更新日期:2016-11-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8688
更新日期:2018-07-01 00:00:00
abstract::Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11293
更新日期:2020-03-01 00:00:00
abstract::Recently, a number of microRNAs (miRNAs) have been reported to play different roles in human cancers, including colorectal cancer (CRC). However, the specific role of miR-758 has not been clarified in CRC. Therefore, the aim of the present study was to explore the role of miR-758 in CRC. RT-qPCR and western blot analy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11516
更新日期:2020-06-01 00:00:00
abstract::The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8975
更新日期:2018-09-01 00:00:00
abstract::Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12358
更新日期:2021-02-01 00:00:00
abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11917
更新日期:2020-10-01 00:00:00
abstract::Ilex kudingcha C.J. Tseng (Kudingcha) is a traditional Chinese drink consumed in East Asia. The present study evaluated the in vitro anticancer effects of Kudingcha in MCF-7 human breast adenocarcinoma cells using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay. At a concentration of 200 μg/...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1253
更新日期:2013-05-01 00:00:00
abstract::Mangiferin, a flavonoid extracted from the mango tree, possesses anti-inflammatory, antibacterial, anti-herpes simplex and antitumor activity, and is able to affect immune function. The present study investigated the anticancer effects of mangiferin treatment on PC3 human prostate cancer cells, and the potential under...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3924
更新日期:2016-01-01 00:00:00
abstract::The aim of the present study was to investigate the immunohistochemical expression of cluster of differentiation (CD) 34 and vascular endothelial growth factor (VEGF) in breast cancer tissue, and their prognostic significance. High CD34 expression levels (microvessel density, >15/HPF) were identified in 27.3% (12/44) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3348
更新日期:2015-08-01 00:00:00
abstract::Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11952
更新日期:2020-10-01 00:00:00