Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma.

abstract：:Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous report...

journal_title：Oncology letters

authors： Fujii T,Sakai E,Takahashi H,Yamada E,Ohkubo H,Higurashi T,Nakajima A

更新日期：2017-06-01 00:00:00

abstract：:Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds ...

journal_title：Oncology letters

authors： Wei X,DU ZY,Cui XX,Verano M,Mo RQ,Tang ZK,Conney AH,Zheng X,Zhang K

更新日期：2012-08-01 00:00:00

abstract：:The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...

journal_title：Oncology letters

authors： Tong N,Zhang J,Chen Y,Li Z,Luo Y,Zuo H,Zhao X

更新日期：2012-06-01 00:00:00

abstract：:MicroRNA (miR)-29a has been associated with carcinogenesis in humans; however, its functional significance in esophageal squamous cell carcinoma (ESCC) is yet to be determined. In the present study, the expression of miR-29a was markedly downregulated in ESCC tissue and the ESCC TE-1 cell line, compared with normal es...

journal_title：Oncology letters

authors： Liu C,Duan P,Li B,Huang C,Jing Y,Yan W

更新日期：2015-01-01 00:00:00

abstract：:Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...

journal_title：Oncology letters

authors： Nishihara K,Suekane S,Ueda K,Nakiri M,Matsuo M,Igawa T

更新日期：2019-06-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the p...

journal_title：Oncology letters

authors： Dumitrascu MC,Mares C,Petca RC,Sandru F,Popescu RI,Mehedintu C,Petca A

更新日期：2020-12-01 00:00:00

abstract：:This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...

journal_title：Oncology letters

authors： Shinsyu A,Bamba S,Kurihara M,Matsumoto H,Sonoda A,Inatomi O,Andoh A,Takebayashi K,Kojima M,Iida H,Tani M,Sasaki M

更新日期：2020-08-01 00:00:00

abstract：:Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...

journal_title：Oncology letters

authors： Pan X,Yang X,Zang J,Zhang S,Huang N,Guan X,Zhang J,Wang Z,Li X,Lei X

更新日期：2017-06-01 00:00:00

abstract：:Individuals >65 years old account for a large proportion of cancer patients, and usually have poor prognoses due to relative weaker physiological function and lower drug tolerance. To characterize the efficacy and safety of dendritic cell (DC)-activated cytokine-induced killer cell (CIK)-mediated treatment, and develo...

journal_title：Oncology letters

authors： Liu Y,Liu H,Liu H,He P,Li J,Liu X,Chen L,Wang M,Xi J,Wang H,Zhang H,Zhu Y,Zhu W,Ning J,Guo C,Sun C,Zhang M

更新日期：2016-12-01 00:00:00

abstract：:In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and...

journal_title：Oncology letters

authors： Xu XM,Zhang ML,Zhang Y,Zhao L

更新日期：2016-11-01 00:00:00

abstract：:The Janus kinase (JAK)2 gene, which is located on chromosome 9p24, is involved in the signaling transduction pathways of the hematopoietic and immune system. Mutations in the JAK2 gene have served as disease markers for myeloproliferative neoplasms (MPNs). The aim of the present study was to investigate the occurrence...

journal_title：Oncology letters

authors： Zhang SP,Li H,Lai RS

更新日期：2015-02-01 00:00:00

abstract：:Renal oncocytoma is one of the most unusual benign lesion, which are usually diagnosed postoperatively, since their differentiation from renal cell carcinoma is challenging. The present study reports two cases of renal oncocytoma in a 60-year-old woman and a 46-year-old man. Relevant clinical and pathological data on ...

journal_title：Oncology letters

authors： Wang Y,Hu YU,Zhai X,Wang W,Dong B,Zhou H

更新日期：2016-07-01 00:00:00

abstract：:Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...

journal_title：Oncology letters

authors： Sun L,Liu M,Luan S,Shi Y,Wang Q

更新日期：2019-09-01 00:00:00

abstract：:Berberine is sourced from multiple medicinal herb resources and is easy to extract. With the advantages of low price, safety and convenience, berberine may have potential for wide clinical use. The present study aimed to investigate whether berberine inhibited the viability of colon cancer and whether it regulated the...

journal_title：Oncology letters

authors： Lü Y,Han B,Yu H,Cui Z,Li Z,Wang J

更新日期：2018-04-01 00:00:00

abstract：:Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...

journal_title：Oncology letters

authors： Lee SR,Shin JW,Kim HO,Son BH,Yoo CH,Shin JH

更新日期：2013-02-01 00:00:00

abstract：:Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in orde...

journal_title：Oncology letters

authors： Li D,Wei X,Ma M,Jia H,Zhang Y,Kang W,Wang T,Shi X

更新日期：2017-04-01 00:00:00

abstract：:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

journal_title：Oncology letters

authors： Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

更新日期：2018-08-01 00:00:00

abstract：:For individualized bevacizumab-based therapy, non-invasive biomarkers are necessary. This study assessed the predictive value of plasma vascular endothelial growth factor (VEGF)-A, soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 levels as biomarkers for clinical response and survival in advanced colorectal cancer (CRC) ...

journal_title：Oncology letters

authors： Aoyagi Y,Iinuma H,Horiuchi A,Shimada R,Watanabe T

更新日期：2010-03-01 00:00:00

abstract：:Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...

journal_title：Oncology letters

authors： Xie H,Lu Q,Wang H,Zhu X,Guan Z

更新日期：2019-01-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:Numerous genetic alterations have been implicated in the development of prostate cancer (PCa). DNA and protein microarrays have enabled the identification of genes associated with apoptosis, which is important in PCa development. Despite the molecular mechanisms are not entirely understood, inhibition of apoptosis is ...

journal_title：Oncology letters

authors： Salemi M,Barone N,La Vignera S,Condorelli RA,Recupero D,Galia A,Fraggetta F,Aiello AM,Pepe P,Castiglione R,Vicari E,Calogero AE

更新日期：2016-10-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...

journal_title：Oncology letters

authors： Zou B,Guan X,Zhang W,Wang D,Xu K,Yuan DY,Meng Z,Zhang B

更新日期：2019-12-01 00:00:00

abstract：:Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...

journal_title：Oncology letters

authors： Gamoh S,Wato M,Akiyama H,Tsuji K,Ishikawa H,Naruse K,Yoshida H,Morita S,Tanaka A,Shimizutani K

更新日期：2017-12-01 00:00:00

abstract：:The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC ...

journal_title：Oncology letters

authors： Aoun F,Kourie HR,El Rassy E,van Velthoven R

更新日期：2016-09-01 00:00:00

abstract：:Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...

journal_title：Oncology letters

authors： Tan KT,Chen PW,Li S,Ke TM,Lin SH,Yang CC

更新日期：2019-08-01 00:00:00

abstract：:With the continuous advancement of clinical diagnostic techniques, including imaging technology, the incidence of confirmed multiple primary cancers or double primary carcinoma increases yearly. However, studies reporting synchronization surgery performed for primary dual esophageal gastric cancer are rare. The presen...

journal_title：Oncology letters

authors： Zhang XT,Wang W,Zhu Q,Cao M,Jiang ZM,Zang QI

更新日期：2015-08-01 00:00:00

abstract：:Gliomas are the most common primary tumors in adult central nervous system and result in disappointing survival outcomes. FOXL1, as a transcription factor, plays an important role in regulating the expression of genes involved in cell metabolism, proliferation and differentiation. In this study, we investigated the re...

journal_title：Oncology letters

authors： Chen A,Zhong L,Lv J

更新日期：2019-07-01 00:00:00

abstract：:The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...

journal_title：Oncology letters

authors： Zong Z,Luo Y,Ying H,Wang A,Li H,Yi C

更新日期：2018-11-01 00:00:00

abstract：:No evidence currently exists to demonstrate the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with unresectable colorectal cancer liver metastases (CRLM). Therefore, we retrospectively investigated the correlation between serum CEA and CA19-9 levels and ove...

journal_title：Oncology letters

authors： Mitsuyama Y,Shiba H,Haruki K,Fujiwara Y,Furukawa K,Iida T,Hayashi T,Ogawa M,Ishida Y,Misawa T,Kashiwagi H,Yanaga K

更新日期：2012-04-01 00:00:00

abstract：:The endogenous lipid metabolism network is associated with the occurrence and progression of malignancies. Endocannabinoids and ceramides have demonstrated their anti-proliferative and pro-apoptotic properties in a series of cancer studies. The aim of the present study was to evaluate the expression patterns of endoca...

journal_title：Oncology letters

authors： Yang J,Tian Y,Zheng R,Li L,Qiu F

更新日期：2019-08-01 00:00:00