Abstract:
:Recently, a number of microRNAs (miRNAs) have been reported to play different roles in human cancers, including colorectal cancer (CRC). However, the specific role of miR-758 has not been clarified in CRC. Therefore, the aim of the present study was to explore the role of miR-758 in CRC. RT-qPCR and western blot analysis were used to quantify the expression of miR-758 and genes. The function of miR-758 in CRC was investigated using Transwell, CCK-8 and luciferase reporter assays. According to the results, the downregulation of miR-758 expression was associated with aggressive behavior and poor prognosis in CRC patients. miR-758 was shown to restrain the cell viability and metastasis in CRC. In addition, it was confirmed that miR-758 directly targets PAX6 and inhibits CRC progression through targeting PAX6. The results also revealed that miR-758 blocked EMT and PI3K/AKT pathway in CRC. In conclusion, miR-758 acts as a tumor suppressor in CRC by downregulating PAX6.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Zhang X,Xu J,Zhang H,Sun J,Li N,Huang Xdoi
10.3892/ol.2020.11516subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3923-3930issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-11516journal_volume
19pub_type
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