Abstract:
:Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non-metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Dong G,Mao Q,Xia W,Xu Y,Wang J,Xu L,Jiang Fdoi
10.3892/ol.2016.4168subject
Has Abstractpub_date
2016-03-01 00:00:00pages
1980-1986issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-4168journal_volume
11pub_type
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