Abstract:
:We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings suggested a subarachnoid haemorrhage (SAH) and/or meningeal carcinomatosis. The results of a cytological examination of the CSF showed neoplastic epithelial cells consistent with metastatic melanoma cells. Resection of metastatic posterior fossa lesions is often cited as a risk factor for leptomeningeal dissemination, however, when the resection is limited to the anterior fossa, this complication is relatively rare. In contrast, SAH may be a complication of leptomeningeal dissemination and responsible for acute meningeal syndrome. Treatment with high doses of corticoids did not show any improvement, and intrathecal chemotherapy was not possible due to the patient's poor functional status. She succumbed 1 week after admission.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Moyano MS,Gutiérrez-Gutiérrez G,Rodríguez-Esteban I,Crespo GS,Casado Edoi
10.3892/ol.2010.194subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1101-1104issue
6eissn
1792-1074issn
1792-1082pii
ol-01-06-1101journal_volume
1pub_type
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