Abstract:
:Leiomyosarcomas account for ~24% of all adult sarcomas, and develop predominantly either in the uterus [uterine leiomyosarcoma (ULMS)] or in deep soft tissue or the retroperitoneum [non-uterine leiomyosarcoma (NULMS)]. Leiomyosarcomas are relatively chemoresistant tumors, and the prognosis of patients with leiomyosarcomas is poor. Cancer-testis (CT) antigens are considered promising immunotherapeutic targets because of their restricted expression in normal tissue, except in the testis. Little is known about the expression of CT antigens in leiomyosarcomas. In the present study, the protein expression of the CT antigens MAGE family member A (MAGEA)1, MAGEA3, MAGEA4, G antigen 7 (GAGE7) and cancer/testis antigen 1 (NY-ESO-1) in ULMS and NULMS were investigated using immunohistochemistry (IHC), and their expression profiles compared. In ULMS and NULMS, positive expression was observed in 11/32 (31%) and 1/31 (3%; MAGEA1), 15/32 (47%) and 5/31 (16%; MAGEA3), 11/32 (34%) and 3/31 (10%; MAGEA4), 23/32 (72%) and 11/31 (35%; GAGE7) and 3/32 (9%) and 0/31 (0%; NY-ESO-1), respectively. The ULMSs demonstrated significantly higher positive expression of MAGEA1 (P=0.0034), MAGEA3 (P=0.0141), MAGEA4 (P=0.0319) and GAGE7 (P=0.0054) compared with the NULMSs. The ULMSs also had significantly higher IHC scores for MAGEA1 (P=0.0023), MAGEA3 (P=0.0474), MAGEA4 (P=0.011), GAGE7 (P=0.0319) and NY-ESO-1 (P=0.0437). The results of the present study support the potential utility of MAGEA1, MAGEA3, MAGEA4 and GAGE7 in ULMS and GAGE7 in NULMS as immunotherapeutic targets.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Iura K,Kohashi K,Yasutake N,Ishii T,Maekawa A,Bekki H,Otsuka H,Yamada Y,Yamamoto H,Ohishi Y,Matsumoto Y,Iwamoto Y,Oda Ydoi
10.3892/ol.2017.7274subject
Has Abstractpub_date
2018-01-01 00:00:00pages
441-446issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-7274journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1904
更新日期:2014-05-01 00:00:00
abstract::Salidroside has a wide range of pharmacological activities, including antitumor, anti-inflammatory, analgesic, antibacterial, antiviral and anti-fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were ex...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8982
更新日期:2018-09-01 00:00:00
abstract::Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.767
更新日期:2012-09-01 00:00:00
abstract::In recent decades, thyroid cancer (TC) has become one of the most common endocrine malignancies. Next-generation sequencing of paired TC and adjacent healthy thyroid tissues demonstrated that polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) may serve as a tumour suppressor gene in thyroid cancer. However, the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10632
更新日期:2019-09-01 00:00:00
abstract::The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1556
更新日期:2013-11-01 00:00:00
abstract::Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5785
更新日期:2017-04-01 00:00:00
abstract::The molecular profile of low-grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low-grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP-2, MMP-7 and MMP-9 was detected by immunohistochemistry in a coho...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_2011.387
更新日期:2011-11-01 00:00:00
abstract::Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. Recently, ARNT has been reported to a play role in pancreatic-islet function in type 2 diabetes. However, the role of ARNT in kidney cancer h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11917
更新日期:2020-10-01 00:00:00
abstract::It has been demonstrated that microRNA-497 (miR-497) acts as a tumor suppressor and is involved in tumor progression, development and metastasis in several types of cancer. However, little is known about the exact role of miR-497 in osteosarcoma (OS). The aim of the current study was to investigate the potential role ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4162
更新日期:2016-03-01 00:00:00
abstract::Previous studies have demonstrated that the chronic administration of valproic acid (VPA) suppresses angiogenesis in vivo; however, the mechanisms implicated in VPA-induced autophagy remain unclear. The current study aimed to assess VPA-induced autophagy in three prostate cancer cell lines (PC3, DU145 and LNCaP), in a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4880
更新日期:2016-09-01 00:00:00
abstract::Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downreg...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9208
更新日期:2018-10-01 00:00:00
abstract::The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6825
更新日期:2017-10-01 00:00:00
abstract::The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6949
更新日期:2017-11-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2017.5668.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,已发布勘误
doi:10.3892/ol.2017.6875
更新日期:2017-11-01 00:00:00
abstract::The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5650
更新日期:2017-03-01 00:00:00
abstract::Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1454
更新日期:2013-09-01 00:00:00
abstract::Breast cancer 1 (BRCA1) and insulin-like growth factor 1 receptor (IGF1R) are critical in ovarian cancer progression. However, the crosstalk between the BRCA1 and IGF1R signaling pathways in ovarian cancer remains largely unknown. The effects of BRCA1 on IGF1R were assessed in 121 serous ovarian cancer patients (BRCA1...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1929
更新日期:2014-05-01 00:00:00
abstract::A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1987
更新日期:2014-06-01 00:00:00
abstract::Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce imm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3295
更新日期:2015-08-01 00:00:00
abstract::We previously reported the case of a 56-year-old male who underwent surgical treatment for gastric hepatoid adenocarcinoma and splenic metastasis. The present study reports the case of the same patient who underwent successful ex vivo hepatectomy and partial liver autotransplantation. Computed tomography scans demonst...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3041
更新日期:2015-05-01 00:00:00
abstract::DNA hypermethylation plays a major role in the regulation of gene expression in differentiation, development and diseases. The DNA mismatch repair system, which includes Mut-S-Homologon-2 (MSH2) protein, is essential to maintain the stability of the genome during repeated duplication. This study aimed to investigate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2482
更新日期:2014-11-01 00:00:00
abstract::Berberine is sourced from multiple medicinal herb resources and is easy to extract. With the advantages of low price, safety and convenience, berberine may have potential for wide clinical use. The present study aimed to investigate whether berberine inhibited the viability of colon cancer and whether it regulated the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7997
更新日期:2018-04-01 00:00:00
abstract::Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10935
更新日期:2019-12-01 00:00:00
abstract::Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-i...
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2016.5093
更新日期:2016-11-01 00:00:00
abstract::Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11293
更新日期:2020-03-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9200
更新日期:2018-10-01 00:00:00
abstract::Scalp angiosarcoma is a rare, extremely aggressive cutaneous malignancy with poor patient prognosis. The present study reviewed the cases of 42 patients who presented scalp angiosarcoma and were treated at the Zhongshan Hospital of Fudan University between January 2002 and December 2013. The clinical characteristics, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10886
更新日期:2019-11-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::Neurotrophins are a family of growth factors that regulate neural survival, development, function and plasticity in the central and the peripheral nervous system. There are four neurotrophins: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Among them, BDNF is the m...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.9854
更新日期:2019-02-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12091
更新日期:2020-11-01 00:00:00