Abstract:
:Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective of the present study was to determine the protein expression levels and clinical significance of EHD1, EGFR, caveolin-1 (CAV-1) and RAB11 family interacting protein 3 (RAB11FIP3) in PTC. PTC specimens were analyzed for EHD1, EGFR, CAV-1 and RAB11FIP3 expression via immunohistochemistry and western blotting. The associations between protein expression and clinicopathological features were assessed. EHD1, EGFR, CAV-1 and RAB11FIP3 expression levels were increased in human PTC. Additionally, the expression level of EHD1 protein was significantly associated with tumor size, lymph node metastasis and EGFR expression (P<0.05). CAV-1 was associated with tumor size and EGFR expression (P<0.05). EGFR was only associated with lymph node metastasis (P=0.027) and RAB11FIP3 was not associated with any clinicopathological characteristics. The correlations between EHD1 and EGFR (r=0.564, P<0.05), CAV-1 (r=0.865, P<0.01) and RAB11FIP3 (r=0.504, P<0.05) were statistically significant. Overall, EHD1, CAV-1 and RAB11FIP3, which are key proteins in endocytotic recycling, promote PTC tumorigenesis through the regulation of the transport of EGFR.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Liu Y,Liang Y,Li M,Liu D,Tang J,Yang W,Tong D,Jin Xdoi
10.3892/ol.2018.9200subject
Has Abstractpub_date
2018-10-01 00:00:00pages
4263-4270issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-9200journal_volume
16pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Famitinib (SHR1020), a novel multi-targeted tyrosine kinase inhibitor, has antitumor activity against several solid tumors via targeting vascular endothelial growth factor receptor 2, c-Kit and platelet-derived growth factor receptor β. The present study investigated famitinib's activity against human gastric cancer c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4909
更新日期:2016-09-01 00:00:00
abstract::Small cell carcinoma of the rectum is extremely rare. The present study aimed to improve the recognition of computed tomography (CT) and magnetic resonance imaging (MRI) features observed in patients with small cell carcinoma of the rectum. A total of 4 cases of patients with histologically confirmed small cell carcin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4136
更新日期:2016-03-01 00:00:00
abstract::Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10783
更新日期:2019-11-01 00:00:00
abstract::Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9474
更新日期:2018-11-01 00:00:00
abstract::Previous studies have demonstratedf that heat stress can induce injury of the central nervous system and lead to neuronal cell apoptosis. However, the molecular mechanisms underlying these cellular changes remain unclear. In the present study, flow cytometry was used to investigate heat-stress-induced apoptosis, and c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7360
更新日期:2018-01-01 00:00:00
abstract::Lung is one of the most common sites for bladder cancer to metastasize. Although the involvement of the epithelial-to-mesenchymal transition (EMT) in bladder cancer progression has been established, the mechanism of EMT induction remains unclear. In order to investigate this, T24-parental (P) and T24-lung (L) bladder ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7764
更新日期:2018-03-01 00:00:00
abstract::Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8369
更新日期:2018-06-01 00:00:00
abstract::Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7386
更新日期:2018-01-01 00:00:00
abstract::A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1447
更新日期:2013-09-01 00:00:00
abstract::Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10178
更新日期:2019-06-01 00:00:00
abstract::Breast cancer is the most common malignant tumor in women in the majority of countries, such as China, Britain and Australia, and its morbidity and mortality rates remain very high. Long non-coding RNAs (lncRNAs) are non-coding RNAs (ncRNAs) >200 nucleotides in length that lack open reading frames. LncRNA H19 is a tra...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.11093
更新日期:2020-01-01 00:00:00
abstract::Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11938
更新日期:2020-10-01 00:00:00
abstract::Sarcomatoid carcinomas exhibit features that are common to epithelial and mesenchymal tumors. These carcinomas are rare, particularly in the small intestine. In the current case report, we describe a case of an intestinal sarcomatoid carcinoma in a 70-year-old Chinese female. Sarcomatoid carcinoma was confirmed based ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1378
更新日期:2013-08-01 00:00:00
abstract::Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.518
更新日期:2012-03-01 00:00:00
abstract::The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6692
更新日期:2017-10-01 00:00:00
abstract::The role of tumor-infiltrating lymphocytes (TILs) suggests that cancer is a disease with not only a genetic, but also an immunological basis. Additionally, immune cell infiltration is an important feature of oral cancer. C-X-C motif chemokine ligand 12 (CXCL12) serves an important role in immune suppression in the tum...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10415
更新日期:2019-08-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8472
更新日期:2018-06-01 00:00:00
abstract::A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2736
更新日期:2015-02-01 00:00:00
abstract::Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000127
更新日期:2010-07-01 00:00:00
abstract::Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6473
更新日期:2017-09-01 00:00:00
abstract::Death associated protein kinase 1 (DAPK1) is a notable serine/threonine kinase involved in the regulation of multiple cellular pathways, including apoptosis and autophagy. Although DAPK1 is usually considered to be a tumor suppressor, it was previously reported to promote the viability of p53 mutant cancer cell lines ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8439
更新日期:2018-06-01 00:00:00
abstract::Nanoparticle albumin-bound (nab)-paclitaxel appears to exhibit better response rates in patients with metastatic urothelial cancer of the bladder whom are pretreated with nab-paclitaxel compared with conventional paclitaxel. Paclitaxel may induce multidrug resistance in patients with cancer, while the mechanisms of re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5986
更新日期:2017-06-01 00:00:00
abstract::Distant metastases from colorectal cancer (CRC) most frequently spread to the liver and lungs. CRC metastasis to the kidney is extremely rare and may be generally associated with an unfavorable prognosis. Thus, patients with metastatic CRC and kidney metastasis are a diagnostic and therapeutic challenge. The present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3290
更新日期:2015-08-01 00:00:00
abstract::Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.471
更新日期:2012-02-01 00:00:00
abstract::Acute myeloid leukemia (AML) is a highly heterogeneous disease that remains untreatable. MicroRNAs (miRNAs or miRs) play important roles in the pathogenesis of leukemia. miR-21 is highly expressed in multiple types of human cancer and displays oncogenic activities; however, the clinical significance of miR-21 in AML r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12380
更新日期:2021-02-01 00:00:00
abstract::Nucleobindin 2 (NUCB-2) is a multifunctional protein that contains several functional domains and is associated with a wide variety of biological processes, such as food intake and energy homeostasis. NUCB-2 has been demonstrated to be associated with worse malignant outcomes and cell migration in breast and prostate ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11526
更新日期:2020-06-01 00:00:00
abstract::Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9677
更新日期:2019-01-01 00:00:00
abstract::Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce imm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3295
更新日期:2015-08-01 00:00:00
abstract::The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion and metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this invasion and metastasis, and transient receptor potential polycystic 2 (TRPP2) enhances metastasis and invasion by regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9752
更新日期:2019-02-01 00:00:00
abstract::Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7437
更新日期:2018-01-01 00:00:00