Abstract:
:The present study aimed to analyse the relationship between tumour-infiltrating immune cells (TIICs) and the prognosis of bladder cancer (BC). In the present study, an established computational method (CIBERSORT) was used to analyse the gene expression profile of BC from 409 patients to infer the number of infiltrating immune cells among 22 immune cell subsets. The relationship between each cell type and overall survival (OS) was further analysed. Single-sample GSEA and ESTIMATE algorithms were performed to evaluate the composition of immune microenvironment in each immune cluster. A significant difference in immune cell infiltration between BC and bladder tissue was observed. Increased natural killer and CD8+ T cell infiltration was associated with longer OS, whereas a higher percentage of M0 macrophages among the total immune cells was associated with shorter OS. The number of M0 macrophages increased with increasing BC stage, whereas the percentage of activated memory CD4+ and CD8+ T cells decreased. Patients with BC were divided into three subgroups by hierarchical cluster analysis of immune cells, and each cluster was associated with distinct survival and immune characteristics. The data indicated differences in the cellular composition of TIICs in patients with BC. Moreover, these TIICs were shown to be potential drug targets and reliable prognostic indicators.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang Y,Ba HJ,Liu ZC,Deng XB,Zhou Mdoi
10.3892/ol.2020.11750subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1677-1684issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-11750journal_volume
20pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in cervical carcinogenesis remains unclear. I...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3143
更新日期:2015-06-01 00:00:00
abstract::Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12358
更新日期:2021-02-01 00:00:00
abstract::Acute myeloid leukaemia (AML) is a type of heterogeneous disease derived from haematopoietic stem cells. Cytogenetic characterisation is essential for diagnosis and prognosis stratification. Here, we present the case of a 43-year-old female diagnosed with leukaemia, who demonstrated a rare chromosomal change of t(11; ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3511
更新日期:2015-10-01 00:00:00
abstract::RNA interference (RNAi) is a powerful technology for suppressing gene function. In most studies, small interfering RNAs (siRNAs) consist of one short hairpin RNA (shRNA) and, therefore, are often unable to achieve loss-of-function of their target genes. In the current study, an RNAi vector containing three shRNAs unde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5672
更新日期:2017-03-01 00:00:00
abstract::Linked color imaging (LCI) is a novel endoscopic system used to increase color contrast. As LCI does not decrease luminal brightness, it may improve the detection of colonic neoplasms. However, the extent to which LCI improves the visibility of colonic polyps has not yet been determined. Between December 2016 and May ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10917
更新日期:2019-11-01 00:00:00
abstract::Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8051
更新日期:2018-04-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::HER2 amplification occurs in ~20% of gastric cancer (GC) cases; however, in gastric and gastroesophageal junction cancer with HER2 gene amplification, trastuzumab in combination with cisplatin (DDP)-based chemotherapy has been reported to improve the oncological outcome. The aim of the present study was to evaluate th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2793
更新日期:2015-02-01 00:00:00
abstract::Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2089
更新日期:2014-07-01 00:00:00
abstract::The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8479
更新日期:2018-06-01 00:00:00
abstract::Salidroside has a wide range of pharmacological activities, including antitumor, anti-inflammatory, analgesic, antibacterial, antiviral and anti-fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were ex...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8982
更新日期:2018-09-01 00:00:00
abstract::The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6443
更新日期:2017-08-01 00:00:00
abstract::Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.918
更新日期:2012-12-01 00:00:00
abstract::The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5477
更新日期:2017-02-01 00:00:00
abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11897
更新日期:2020-10-01 00:00:00
abstract::Management of multinodular hepatocellular carcinoma (HCC) in the intermediate Barcelona Clinic Liver Cancer (BCLC)-B stage is controversial. The aim of the present study as to identify the subgroup of patients with BCLC-B HCC who could benefit from liver resection. The present study retrospectively analyzed the outcom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9420
更新日期:2018-11-01 00:00:00
abstract::The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000014
更新日期:2010-01-01 00:00:00
abstract::Secretory breast carcinoma is a very rare and distinct subtype of breast cancer, characterized by the presence of intracellular and extracellular secretory material. Secretory breast carcinoma has a good clinical outcome and systemic involvement is rare. The majority of studies of this tumor have been case reports or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2213
更新日期:2014-08-01 00:00:00
abstract::Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1275
更新日期:2013-06-01 00:00:00
abstract::The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9119
更新日期:2018-09-01 00:00:00
abstract::[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,撤回出版物
doi:10.3892/ol.2019.10108
更新日期:2019-05-01 00:00:00
abstract::Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4628
更新日期:2016-07-01 00:00:00
abstract::Xeroderma pigmentosum group C (XPC) is a DNA-damage-recognition gene active at the early stage of DNA repair. XPC also participates in regulation of cell-cycle checkpoint and DNA-damage-induced apoptosis. In the present study, the expression levels of genes involved in nucleotide excision repair (NER) were assessed in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8127
更新日期:2018-05-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7884
更新日期:2018-04-01 00:00:00
abstract::The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3874
更新日期:2016-01-01 00:00:00
abstract::The occurrence of primary carcinoma of the ureteral stump following radical nephrectomy for renal cell carcinoma is extremely rare; 7 patients with the disease have been reported previously. All these patients were males with transitional cell carcinoma. The current study reports the case of a 61-year-old woman, who p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4426
更新日期:2016-05-01 00:00:00
abstract::Choroidal melanoma is the most common primary intraocular tumor in adults. Cepharanthine (CEP), a natural alkaloid extracted from the roots of Stephania cepharantha Hayata, has been demonstrated to inhibit the proliferation of various cancer cells. However, its potential anticancer effect in choroidal melanoma has not...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5945
更新日期:2017-05-01 00:00:00
abstract::Overexpression of adenosine triphosphate-binding cassette (ABC) transport protein is emerging as a critical contributor to anticancer drug resistance. The eukaryotic translation initiation factor (eIF) 4F complex, the key modulator of mRNA translation, is regulated by the phosphoinositide 3-kinase-AKT-mammalian target...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6049
更新日期:2017-06-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6211
更新日期:2017-07-01 00:00:00
abstract::Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.710
更新日期:2012-08-01 00:00:00