Abstract:
:Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds to inhibit NF-κB activity in PC-3 cells was also determined. Five out of the six curcumin analogues (A(2)-A(6)) had stronger inhibitory effects compared to curcumin on the growth of cultured PC-3 cells. Compounds A(2)-A(6) also had stronger stimulatory effects on apoptosis in PC-3 cells than curcumin, and these curcumin analogues more potently inhibited NF-κB activity than curcumin. The inhibitory effects of these compounds on NF-κB activity correlated with their effects on growth inhibition and apoptosis stimulation in PC-3 cells. The results of the present study provide a rationale for in vivo studies with A(2)-A(6) using suitable animal models of prostate cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wei X,DU ZY,Cui XX,Verano M,Mo RQ,Tang ZK,Conney AH,Zheng X,Zhang Kdoi
10.3892/ol.2012.710subject
Has Abstractpub_date
2012-08-01 00:00:00pages
279-284issue
2eissn
1792-1074issn
1792-1082pii
ol-04-02-0279journal_volume
4pub_type
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