Prognosis and treatment differences between initial and second primary chondrosarcoma.

abstract：:Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...

journal_title：Oncology letters

authors： Liu D,Li R,Guo X,Pang L,Zang Y,Liu K,Chen D

更新日期：2018-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...

journal_title：Oncology letters

authors： Zhang L,Zheng C,Sun Z,Wang H,Wang F

更新日期：2019-10-01 00:00:00

abstract：:The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...

journal_title：Oncology letters

authors： Shiozawa K,Watanabe M,Ikehara T,Kobayashi K,Ochi Y,Suzuki Y,Fuchinoue K,Yoneda M,Kenmochi T,Okubo Y,Mori T,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

更新日期：2016-01-01 00:00:00

abstract：:Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...

journal_title：Oncology letters

authors： Lee SR,Shin JW,Kim HO,Son BH,Yoo CH,Shin JH

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to investigate the safety and efficacy of long intestinal tube placement under fluoroscopic guidance for the treatment of malignant bowel obstruction (MBO). The cases of 74 patients with MBO who underwent long intestinal tube placement under fluoroscopic guidance during the period betw...

journal_title：Oncology letters

authors： Lai H,Wu K,Liu Y,Zeng Z,Zhang B

更新日期：2019-06-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...

journal_title：Oncology letters

authors： Tanaka K,Oshikawa G,Akiyama H,Ishida S,Nagao T,Yamamoto M,Miura O

更新日期：2017-07-01 00:00:00

abstract：:The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...

journal_title：Oncology letters

authors： Zheng Y,Li YF,Wang W,Chen YM,Wang DD,Zhao JJ,Pan QZ,Jiang SS,Zhang XF,Yuan SQ,Qiu HB,Huang CY,Zhao BW,Zhou ZW,Xia JC

更新日期：2015-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in the insulin-like growth factor-1 (IGF-1) receptor signalling pathway during experimental hepatocarcinogenesis. The aim of this study was ...

journal_title：Oncology letters

authors： Aleem E,Elshayeb A,Elhabachi N,Mansour AR,Gowily A,Hela A

更新日期：2012-03-01 00:00:00

abstract：:Linked color imaging (LCI) is a novel endoscopic system used to increase color contrast. As LCI does not decrease luminal brightness, it may improve the detection of colonic neoplasms. However, the extent to which LCI improves the visibility of colonic polyps has not yet been determined. Between December 2016 and May ...

journal_title：Oncology letters

authors： Tanaka Y,Inoue T,Kakimoto K,Nakazawa K,Tawa H,Hirata Y,Okada T,Nouda S,Kawakami K,Takeuchi T,Egashira Y,Higuchi K

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemis...

journal_title：Oncology letters

authors： Pei YY,Li GC,Ran J,Wei FX

更新日期：2017-12-01 00:00:00

abstract：:A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...

journal_title：Oncology letters

authors： Liu LH,Yang XF

更新日期：2016-06-01 00:00:00

abstract：:The Janus kinase (JAK)2 gene, which is located on chromosome 9p24, is involved in the signaling transduction pathways of the hematopoietic and immune system. Mutations in the JAK2 gene have served as disease markers for myeloproliferative neoplasms (MPNs). The aim of the present study was to investigate the occurrence...

journal_title：Oncology letters

authors： Zhang SP,Li H,Lai RS

更新日期：2015-02-01 00:00:00

abstract：:Liver kinase B1 (LKB1) encodes a serine/threonine kinase and functions as a tumor suppressor. LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in L...

journal_title：Oncology letters

authors： Ma Q,Xiao P,Sun L,Wang J,Zhong D

更新日期：2018-07-01 00:00:00

abstract：:Enhancement of antibody-dependent cellular cytotoxicity (ADCC) with some modalities may be a promising approach to enhance the efficacy of therapeutic monoclonal antibodies (mAbs). It has previously been demonstrated that the removal of fucose from antibody oligosaccharides (defucosylation) leads to augmentation of AD...

journal_title：Oncology letters

authors： Nakajima T,Okayama H,Ashizawa M,Noda M,Aoto K,Saito M,Monma T,Ohki S,Shibata M,Takenoshita S,Kono K

更新日期：2018-02-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to s...

journal_title：Oncology letters

authors： Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:The aim of the present study was to investigate the expression and role of microRNA-26a (miR-26a) in lung cancer, and to verify whether differentially expressed in adenocarcinoma of the lung (DAL-1) is the target protein of miR-26a. mRNA expression levels of miR-26a and DAL-1 were detected using reverse transcription-...

journal_title：Oncology letters

authors： Cai T,Guan X,Wang H,Fang Y,Long J,Xie X,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:The role of laparoscopic resection for large gastric gastrointestinal stromal tumors (GISTs), particularly those >5 cm, remains under debate due the possibility of intraoperative tumor rupture. To determine the feasibility and safety of the laparoscopic approach in the treatment of large gastric GISTs, a prospective s...

journal_title：Oncology letters

authors： Cao F,Li A,Li J,Fang YU,Li F

更新日期：2015-10-01 00:00:00

abstract：:K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...

journal_title：Oncology letters

authors： Peng N,Zhao X

更新日期：2014-08-01 00:00:00

abstract：:Nervous system polycomb 1 (NSPc1) is a member of the polycomb group (PcG) family of proteins and has been demonstrated to maintain the differentiation and pluripotency of stem cells. Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the control of pluripotency and differentiation in embryonic and...

journal_title：Oncology letters

authors： Liang Z,Wang Y,Li H,Sun Y,Gong Y

更新日期：2019-06-01 00:00:00

abstract：:The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...

journal_title：Oncology letters

authors： Ikeda S,Naruse K,Nagata C,Kuramochi M,Onuki T,Inagaki M,Suzuki K

更新日期：2015-05-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Polydatin, extracted from Polygonum cuspidatum, is known for its anti-platelet aggregation and anti-inflammatory effects. However, studies on the association of polydatin with cancer are limited, particularly with regards to epithelial-mesenchymal transition (EMT)-associated migration and invasion of cancer cells. The...

journal_title：Oncology letters

authors： Jiang J,Chen Y,Dong T,Yue M,Zhang Y,An T,Zhang J,Liu P,Yang X

更新日期：2019-05-01 00:00:00

abstract：:To determine the radiosensitizing effect of apatinib on esophageal cancer cells, and to preliminarily investigate the underlying mechanism, KYSE-150 cells were treated with apatinib, x-ray or apatinib combined with x-ray, and compared with a blank control. It was observed that apatinib significantly inhibited vascular...

journal_title：Oncology letters

authors： Hu L,Sun F,Sun Z,Ni X,Wang J,Wang J,Zhou M,Feng Y,Kong Z,Hua Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...

journal_title：Oncology letters

authors： Petroni S,Caldarola L,Scamarcio R,Giotta F,Latorre A,Mangia A,Simone G

更新日期：2016-11-01 00:00:00

abstract：:The prognosis following surgical treatment of gastric carcinoma (GC) or gastroesophageal junction (GEJ) adenocarcinoma remains poor. Although adjuvant chemo-radiotherapy with 5-fluorouracil has been shown to be beneficial, a high rate of distant failure has been reported. Thus, the toxicity profile and efficacy of an ...

journal_title：Oncology letters

authors： Shulman K,Haim N,Wollner M,Bernstein Z,Abdah-Bortnyak R,Bar-Sela G

更新日期：2012-05-01 00:00:00

abstract：:The present study aimed to reveal the key long non-coding RNAs (lncRNAs) and the potential molecular mechanisms of XAV939 treatment in non-small cell lung cancer (NSCLC). The NSCLC cell line, NCI-H1299, was cultured with 10 µM XAV939 for 12 h, and NCI-H1299 cells without XAV939 treatment were used as controls. Followi...

journal_title：Oncology letters

authors： Yu H,Han Z,Xu Z,An C,Xu L,Xin H

更新日期：2019-06-01 00:00:00

abstract：:Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-i...

journal_title：Oncology letters

authors： Zhang XY,Zhang PY

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients an...

journal_title：Oncology letters

authors： Al-Muhtaseb SI

更新日期：2014-12-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00