lncRNAs combine and crosstalk with NSPc1 in ATRA-induced differentiation of U87 glioma cells.

abstract：:The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...

journal_title：Oncology letters

authors： Wang Z,Zhang N,Song R,Fan R,Yang L,Wu L

更新日期：2015-07-01 00:00:00

abstract：:Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...

journal_title：Oncology letters

authors： Yan M,Jing X,Liu Y,Cui X

更新日期：2018-09-01 00:00:00

abstract：:Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...

journal_title：Oncology letters

authors： Sun HF,Jing L,Wu T,Li M,Guo YH,Guo H,Zhao Z,Wang MC,Wang SH,Nan KJ

更新日期：2017-12-01 00:00:00

abstract：:The present study selected and characterized a multidrug-resistant HL-60 human acute promyelocytic leukemia cell line, HL-60/RS, by exposure to stepwise incremental doses of doxorubicin. The drug-resistant HL-60/RS cells exhibited 85.68-fold resistance to doxorubicin and were cross-resistant to other chemotherapeutics...

journal_title：Oncology letters

authors： Chen J,Wei H,Cheng J,Xie B,Wang B,Yi J,Tian B,Liu Z,Wang F,Zhang Z

更新日期：2018-01-01 00:00:00

abstract：:SIRT6, is a member of the NAD-dependent sirtuin family of enzymes, and has been reported as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However, the role of SIRT6 in osteosarcoma has not been investigated. The present study demonstrated that the expression of SIRT6 was downregulated in ...

journal_title：Oncology letters

authors： Gao Y,Qu Y,Zhou Q,Ma Y

更新日期：2019-01-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. Wnt family member 10A (Wnt10a) is an oncogene associated with the carcinogenesis and progression of renal cell carcinoma, and is strongly expressed in the CRC cell line SW480. However, the role of Wnt10a in CRC has been rarely...

journal_title：Oncology letters

authors： Li J,Zhang Z,Wang L,Zhang Y

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...

journal_title：Oncology letters

authors： Su L,Liu M

更新日期：2018-07-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90-95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations...

journal_title：Oncology letters

authors： Asif M,Hussain A,Malik A,Rasool M

更新日期：2015-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) was one of the first cancer types systematically studied at a genomic and transcriptomic level due to its high incidence and aggressivity; however, the detailed mechanism remains unclear, even though it is known that numerous cytokines are involved in the occurrence and development of GBM...

journal_title：Oncology letters

authors： He K,Shi L,Jiang T,Li Q,Chen Y,Meng C

更新日期：2016-10-01 00:00:00

abstract：:Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...

journal_title：Oncology letters

authors： Ning D,Jin M,Xv T,Sun J,Li M

更新日期：2018-09-01 00:00:00

abstract：:The clinical efficiency of bone transport distraction osteogenesis in the reconstruction of large tibial defects following resection of osteosarcoma remains unclear. The current study presents two cases of large tibial defects treated with bone transport distraction using an Orthofix external fixator. Case 1 was a 29-...

journal_title：Oncology letters

authors： Yang Z,Jin L,Tao H,Yang D

更新日期：2016-08-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2012.934.]. ...

journal_title：Oncology letters

authors： Fan L,Wang H,Xia X,Rao Y,Ma X,Ma D,Wu P,Chen G

更新日期：2020-04-01 00:00:00

abstract：:Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...

journal_title：Oncology letters

authors： Liu D,Li R,Guo X,Pang L,Zang Y,Liu K,Chen D

更新日期：2018-06-01 00:00:00

abstract：:Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...

journal_title：Oncology letters

authors： Colombo J,Maciel JM,Ferreira LC,DA Silva RF,Zuccari DA

更新日期：2016-07-01 00:00:00

abstract：:Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...

journal_title：Oncology letters

authors： Xie J,Lin W,Huang L,Xu N,Xu A,Chen B,Watanabe M,Liu C,Huang P

更新日期：2018-09-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:MicroRNA-1470 (miR-1470) is overexpressed in esophageal squamous cell carcinoma (ESCC); however, its role and underlying molecular mechanism remain unknown. The aim of the present study was to explore the tumorigenic role and mechanism of miR-1470 overexpression in ESCC. The expression of miR-1470 in ESCC tissues and ...

journal_title：Oncology letters

authors： Mei LL,Qiu YT,Wang WJ,Bai J,Shi ZZ

更新日期：2017-12-01 00:00:00

abstract：:Glucose Transporter 1 (GLUT1) belongs to the expanding mammalian facilitative glucose transporter family. Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. Whereas malignant cells have an accelerated metabolism with inc...

journal_title：Oncology letters

authors： Reis H,Tschirdewahn S,Szarvas T,Rübben H,Schmid KW,Grabellus F

更新日期：2011-11-01 00:00:00

abstract：:Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...

journal_title：Oncology letters

authors： Wang YD,Chen SX,Ren LQ

更新日期：2016-05-01 00:00:00

abstract：:The response of triple-negative breast cancer (TNBC) to chemotherapy is heterogeneous; particular subtype classifications based on mRNA gene expression analysis have been demonstrated to be associated with a pathological complete response (pCR). The aim of the present study was to investigate additional clinical and p...

journal_title：Oncology letters

authors： Nakashoji A,Matsui A,Nagayama A,Iwata Y,Sasahara M,Murata Y

更新日期：2017-10-01 00:00:00

abstract：:Decreased expression of ten-eleven translocation (TET1, TET2 and TET3) proteins has been reported in various types of cancer. However, the expression levels of TET proteins in cervical cancer (CC) remain to be elucidated. The present study determined the levels of TET1, TET2 and TET3 transcripts in cancerous (n=80) an...

journal_title：Oncology letters

authors： Bronowicka-Kłys DE,Roszak A,Pawlik P,Sajdak S,Sowińska A,Jagodziński PP

更新日期：2017-05-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...

journal_title：Oncology letters

authors： Zhao X,Zhu D,Lu C,Yan D,Li L,Chen Z

更新日期：2016-02-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

journal_title：Oncology letters

authors： Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

更新日期：2018-07-01 00:00:00

abstract：:Gastric cancer is a pathological process of an accumulation of multigene and multistage mutations. A new gene segment, MDSCBC11, has been previously obtained using a gene chip and is negatively associated with gastric cancer. The present study aimed to clone the full cDNA sequence of the MDSCBC11 segment and to detect...

journal_title：Oncology letters

authors： Gan R,Liu X,Zhou Y,Tan Y,Liu H,Li G,Tang Y,Xie H

更新日期：2013-12-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study invest...

journal_title：Oncology letters

authors： Li S,Wang F,Zhai Z,Fu S,Lu J,Zhang H,Guo H,Hu X,Li R,Wang Z,Rodriguez R

更新日期：2017-08-01 00:00:00

abstract：:The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...

journal_title：Oncology letters

authors： You HX,Zhou YH,Tan SY,She TH

更新日期：2014-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...

journal_title：Oncology letters

authors： Li BS,Huang JY,Guan J,Chen LH

更新日期：2018-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogene...

journal_title：Oncology letters

authors： Yang Y,Shen Z,Yan Y,Wang B,Zhang J,Shen C,Li T,Ye C,Gao Z,Peng G,Ye Y,Jiang K,Wang S

更新日期：2017-05-01 00:00:00