Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer.

abstract：:The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...

journal_title：Oncology letters

authors： Komatsu T,Oizumi Y,Kunieda E,Tamai Y,Akiba T,Kogawa A

更新日期：2011-09-01 00:00:00

abstract：:Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...

journal_title：Oncology letters

authors： Hong R,Lee G,Kim H,Kim CS,Kee KH

更新日期：2012-03-01 00:00:00

abstract：:The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differen...

journal_title：Oncology letters

authors： Gao H,Yang M,Zhang X

更新日期：2018-04-01 00:00:00

abstract：:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...

journal_title：Oncology letters

authors： Yan Z,Liu G,Liang M,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...

journal_title：Oncology letters

authors： Yan HC,Xu J,Fang LS,Qiu YY,Lin XM,Huang HX,Han QY

更新日期：2015-04-01 00:00:00

abstract：:Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...

journal_title：Oncology letters

authors： Shi Y,Li X,Chen X,Xu Y,Bo G,Zhou H,Liu Y,Zhou G,Wang Z

更新日期：2017-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-β (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effec...

journal_title：Oncology letters

authors： Kim JB,Lee S,Kim HR,Park SY,Lee M,Yoon JH,Kim YJ

更新日期：2018-06-01 00:00:00

abstract：:Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...

journal_title：Oncology letters

authors： Lee SS,Min H,Ha JY,Kim BH,Choi MS,Kim S

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant che...

journal_title：Oncology letters

authors： Kawajiri H,Takashima T,Aomatsu N,Kashiwagi S,Noda S,Onoda N,Ishikawa T,Hirakawa K

更新日期：2014-03-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affi...

journal_title：Oncology letters

authors： Göstring L,Lindegren S,Gedda L

更新日期：2016-10-01 00:00:00

abstract：:Melanomas affect the foot and ankle region and are associated with a poor prognosis. The aim of the current study was to evaluate the functional and oncological outcomes of salvage surgery using cutaneous flaps for soft tissue reconstruction of the foot and ankle following the extended resection of a melanoma. A retro...

journal_title：Oncology letters

authors： Liu JF,Zhao LR,Lu LJ,Chen L,Liu ZG,Gong X,Liu B

更新日期：2014-11-01 00:00:00

abstract：:1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD), a diamantane derivative, was previously noted as an anticancer compound through anticancer drug screening with NCI-60 human tumor cells. Irinotecan (CPT-11), a semisynthetic derivative of camptothecin, is clinically active in the treatment of colorectal can...

journal_title：Oncology letters

authors： Yang PS,Wang JJ,Wang YH,Jan WC,Cheng SP,Hsu YC

更新日期：2016-05-01 00:00:00

abstract：:Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...

journal_title：Oncology letters

authors： Sun HF,Jing L,Wu T,Li M,Guo YH,Guo H,Zhao Z,Wang MC,Wang SH,Nan KJ

更新日期：2017-12-01 00:00:00

abstract：:In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

journal_title：Oncology letters

authors： Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

更新日期：2013-08-01 00:00:00

abstract：:When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic pre...

journal_title：Oncology letters

authors： Sonohara F,Inokawa Y,Hishida M,Kanda M,Nishikawa Y,Yamada S,Fujii T,Sugimoto H,Kodera Y,Nomoto S

更新日期：2016-12-01 00:00:00

abstract：:Lonidamine, 6-Diazo-5-oxo-L-norleucine (DON) and orlistat are well known inhibitors of glycolysis, glutaminolysis and of de novo fatty acid synthesis, respectively. Although their antitumor effects have been explored in detail, the potential inhibition of the malignant metabolic phenotype and its influence on the expr...

journal_title：Oncology letters

authors： Schcolnik-Cabrera A,Dominguez-Gómez G,Chávez-Blanco A,Ramírez-Yautentzi M,Morales-Bárcenas R,Chávez-Díaz J,Taja-Chayeb L,Dueáas-González A

更新日期：2019-12-01 00:00:00

abstract：:The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected fro...

journal_title：Oncology letters

authors： Chang H,Ma M,Ma R,Zhang C,Zeng W,Xing LQ

更新日期：2016-12-01 00:00:00

abstract：:Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells remains unknown. The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human na...

journal_title：Oncology letters

authors： Liu B,Liu L,Zang A,Song Z,Yang H,Wang Z,Shang Y,Ma T,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...

journal_title：Oncology letters

authors： Yao J,Xu M,Liu Z

更新日期：2020-04-01 00:00:00

abstract：:Clinical application value was investigated of transvaginal color Doppler ultrasound (TV-CDS) combined with serum tumor markers carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF) and osteopontin (OPN) in the diagnosis of ovarian cancer (OC). One hundred and six patients with OC [malignant tumo...

journal_title：Oncology letters

authors： Yu C,Dou T,Liu Y,Liu R

更新日期：2020-08-01 00:00:00

abstract：:The present study reported three rare cases of multicystic vestibular schwannoma with fluid-fluid levels. These three tumors exhibited apparent fluid-fluid levels that demonstrated a radiological appearance of two fluid levels in the cystic area. Two cases had an acute history, whereas one case presented with a chroni...

journal_title：Oncology letters

authors： Li P,Bi Z,Hao S,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:Newcastle disease virus (NDV) has been reported to selectively duplicate in and then destroy tumor cells, whilst sparing normal cells. However, the effect of NDV on lung cancer has yet to be elucidated. In the present study, recombinant NDV (rl-RVG) was applied to lung adenocarcinoma A549 cell tumor-bearing mice to ex...

journal_title：Oncology letters

authors： Yan Y,Jia L,Zhang J,Liu Y,Bu X

更新日期：2014-12-01 00:00:00

abstract：:The present study aimed to investigate the effects of overexpression of interferon-induced transmembrane protein 5 (IFITM5) and IFITM5 c.-14C>T mutation on osteogenic differentiation, and the proliferation, migration and invasion of SaOS2 cells. SaOS2 cells were transfected with plasmids containing wild type IFITM5 (W...

journal_title：Oncology letters

authors： Liu BY,Lu YQ,Han F,Wang Y,Mo XK,Han JX

更新日期：2017-01-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...

journal_title：Oncology letters

authors： Ishida M,Okabe H

更新日期：2012-09-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to s...

journal_title：Oncology letters

authors： Sun J,Lu Y,Yu C,Xu T,Nie G,Miao B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Glucagonoma is an extremely rare pancreatic α-islet cell tumor and is often accompanied by certain clinical symptoms including necrotizing migratory erythema (NME), diabetes, weight loss and anemia. The objectives of the current review were to discern the clinical features, diagnosis, treatment and prognosis of glucag...

journal_title：Oncology letters

authors： Song X,Zheng S,Yang G,Xiong G,Cao Z,Feng M,Zhang T,Zhao Y

更新日期：2018-03-01 00:00:00

abstract：:Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation be...

journal_title：Oncology letters

authors： Jiang P,Yu G,Zhang Y,Xiang Y,Zhu Z,Feng W,Lee W,Zhang Y

更新日期：2014-05-01 00:00:00

abstract：:In the present study, the anti-tumor effects of combination treatment with an siRNA targeting B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E and phosphoinositide 3-kinase (PI3K) signaling pathway inhibitors was investigated in melanoma cell lines harboring BRAFV600E. Human melanoma A375 and WM115 cells were ...

journal_title：Oncology letters

authors： He H,Nan X,Liu S,Zhang L,Yang Z,Wu Y,Zhang L

更新日期：2018-07-01 00:00:00

abstract：:Liver kinase B1 (LKB1) encodes a serine/threonine kinase and functions as a tumor suppressor. LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in L...

journal_title：Oncology letters

authors： Ma Q,Xiao P,Sun L,Wang J,Zhong D

更新日期：2018-07-01 00:00:00