Abstract:
:The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant chemotherapy (NAC) for operable breast cancer and were eligible for the analysis. In total, 10 patients (11.1%) had succumbed to their diseases and 20 (22.2%) had succumbed to their diseases or exhibited recurrences. The OS of patients with triple-negative (TN) tumors was significantly lower than that of patients with other disease subtypes (P=0.016). The DFS of patients with luminal tumors was higher than that of patients with other subtypes. Survival was improved with pCR following NAC (P=0.044). Across all subtypes, patients who achieved pCR exhibited a higher DFS than patients who did not, but not significantly. pCR only improved OS and DFS in the TN disease subtype (P=0.022 and P=0.048, respectively). pCR following NAC may have prognostic value in TN breast cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kawajiri H,Takashima T,Aomatsu N,Kashiwagi S,Noda S,Onoda N,Ishikawa T,Hirakawa Kdoi
10.3892/ol.2014.1792subject
Has Abstractpub_date
2014-03-01 00:00:00pages
663-668issue
3eissn
1792-1074issn
1792-1082pii
ol-07-03-0663journal_volume
7pub_type
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