Application of novel targeted molecular imaging probes in the early diagnosis of upper urinary tract epithelial carcinoma.

abstract：:The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...

journal_title：Oncology letters

authors： Ren HP,Yin XY,Yu HY,Xiao HF

更新日期：2017-04-01 00:00:00

abstract：:In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...

journal_title：Oncology letters

authors： Deng H,Zhen H,Fu Z,Huang X,Zhou H,Liu L

更新日期：2012-01-01 00:00:00

abstract：:Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae) is widely used in traditional Chinese medicine as an antifungal, antibacterial and anti-inflammatory agent. Plumbagin is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. The transcriptional co-fac...

journal_title：Oncology letters

authors： Xue YL,Meng XQ,Ma LJ,Yuan Z

更新日期：2016-08-01 00:00:00

abstract：:Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...

journal_title：Oncology letters

authors： Ning D,Jin M,Xv T,Sun J,Li M

更新日期：2018-09-01 00:00:00

abstract：:Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...

journal_title：Oncology letters

authors： Chen J,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

journal_title：Oncology letters

authors： Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

更新日期：2017-11-01 00:00:00

abstract：:While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...

journal_title：Oncology letters

authors： Svaton M,Fiala O,Krakorova G,Blazek J,Hurdalkova K,Barinova M,Mukensnabl P,Pesek M

更新日期：2020-08-01 00:00:00

abstract：:The histological boundary between benign and malignant vascular tumors is not clear. Thus, the discrepancies between clinical judgement and pathological diagnosis often lead to a difficult clinical decision, and may result in misdiagnosis. In order to develop more effective treatment methods, the clinical and patholog...

journal_title：Oncology letters

authors： Li F,Ma L,Zhang L,Zheng L,Lv X,Fu J

更新日期：2013-02-01 00:00:00

abstract：:Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...

journal_title：Oncology letters

authors： Shen J,Wang Q,Wang J,Su GH,Wang J,Guo SH,Liu YA,Wu Z,Liu RF,Li X,Guo XJ,Cao J,Zhang YH,Wang ZY

更新日期：2015-10-01 00:00:00

abstract：:The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...

journal_title：Oncology letters

authors： Ide H,Jiang G,Mizushima T,Fujita K,Inoue S,Yamaguchi S,Fushimi H,Nonomura N,Miyamoto H

更新日期：2019-01-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...

journal_title：Oncology letters

authors： He J,Mu M,Luo Y,Wang H,Ma H,Guo S,Fang Q,Qian Z,Lu H,Song C

更新日期：2019-03-01 00:00:00

abstract：:In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Sueishi M

更新日期：2014-10-01 00:00:00

abstract：:Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

journal_title：Oncology letters

authors： Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

更新日期：2014-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...

journal_title：Oncology letters

authors： Yamaura T,Muto S,Mine H,Takagi H,Watanabe M,Ozaki Y,Inoue T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2020-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of the heat shock protein (HSP)90 inhibitor AUY922 on the proliferation and migratory ability of renal cell carcinoma (RCC) cells. The expression of HSP90 was measured in vitro using western blotting and quantitative polymerase chain reaction in the ACHN and ...

journal_title：Oncology letters

authors： Zhu J,Zhu Y,Qi W,Qiu W

更新日期：2015-08-01 00:00:00

abstract：:Discovering the underlying signalling pathways that control cancer cells is crucial for understanding their biology and to develop therapeutic regimens. Thus, the aim of the present study was to determine the effect of Cripto-1 on pathways controlling glioblastoma (GBM) cell function. To this end, changes in protein p...

journal_title：Oncology letters

authors： Alowaidi F,Hashimi SM,Alqurashi N,Wood SA,Wei MQ

更新日期：2019-09-01 00:00:00

abstract：:Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...

journal_title：Oncology letters

authors： Köllermann J,Albrecht H,Schlomm T,Huland H,Graefen M,Bokemeyer C,Simon R,Sauter G,Wilczak W

更新日期：2010-07-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

journal_title：Oncology letters

authors： Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

更新日期：2018-07-01 00:00:00

abstract：:The purpose of this study was to evaluate the cytotoxic effect of thalidomide on 4T1 and 4THMpc mouse breast cancer cell lines. Mouse breast cancer cells (4T1) and cells derived from metastatic lesions (4THMpc) were treated with various doses of thalidomide [10(-2)-100 µM dissolved in dimethyl sulfoxide (DMSO) as reco...

journal_title：Oncology letters

authors： Oz ES,Aydemir E,Fışkın K

更新日期：2012-04-01 00:00:00

abstract：:Endostar, a modified recombinant human endostatin, inhibits the growth of a variety of tumors by suppressing neovascularization. Vascular endothelial growth factor (VEGF) has an important role in malignant ascites formation. In order to determine whether Endostar can suppress the formation of ascites and prolong survi...

journal_title：Oncology letters

authors： Wei H,Qin S,Yin X,Chen Y,Hua H,Wang L,Yang N,Chen Y,Liu X

更新日期：2015-06-01 00:00:00

abstract：:A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. To the best of our knowledge, the present study was the first to examine ADAM9 expression in vestibular schwannomas (VS) from patients with and...

journal_title：Oncology letters

authors： Breun M,Schwerdtfeger A,Martellotta DD,Kessler AF,Monoranu CM,Matthies C,Löhr M,Hagemann C

更新日期：2020-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a treatment modality that has clinical applications in both non-neoplastic and neoplastic diseases. PDT involves a light-sensitive compound (photosensitizer), light and molecular oxygen. This procedure may lead to several different cellular responses, including cell death. Alterations in ...

journal_title：Oncology letters

authors： Pacheco-Soares C,Maftou-Costa M,DA Cunha Menezes Costa CG,DE Siqueira Silva AC,Moraes KC

更新日期：2014-08-01 00:00:00

abstract：:Cervical cancer pathogenesis is regulated by numerous factors, including microRNAs. MicroRNA 1246 (miR-1246) has been shown to serve a role in cervical cancer tumorigenesis. However, the mechanisms through which miR-1246 exerts its oncogenic effects are largely unknown. The aim of the current study was to evaluate the...

journal_title：Oncology letters

authors： Du P,Lai YH,Yao DS,Chen JY,Ding N

更新日期：2019-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) and the interleukin (IL)-23/IL-17A axis serve an important role in tumor immunology. In the present study, the activation of the TLR4/myeloid differentiation primary response 88 (MyD88)-mediated signal transduction pathway in human hepatocellular carcinoma (HCC) cells was examined using imm...

journal_title：Oncology letters

authors： Kang Y,Su G,Sun J,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...

journal_title：Oncology letters

authors： Huang JX,Shen SL,Lin M,Xiao W,Chen WC,Lin MS,Yu H,Chen P,Qian RY

更新日期：2012-10-01 00:00:00

abstract：:Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...

journal_title：Oncology letters

authors： Xia Y,Zhang J,Ni X

更新日期：2020-10-01 00:00:00

abstract：:The present study evaluated androgen deprivation methods to determine the approach that most improves the progression-free survival (PFS) of patients with metastatic prostate cancer. Patients had received continuous maximal androgen blockade (MAB) or monotherapy [luteinizing-hormone releasing hormone (LHRH) agonist or...

journal_title：Oncology letters

authors： Min GE,Ahn H

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to assess the expression of microRNA-146a (miR-146a) in human lung adenocarcinoma cells, its effect on cellular behaviors, and the underlying molecular mechanisms. Reverse transcription-quantitative PCR (RT-qPCR) was used to measure miR-146a expression in the human normal lung epitheli...

journal_title：Oncology letters

authors： Yuan F,Zhang S,Xie W,Yang S,Lin T,Chen X

更新日期：2020-06-01 00:00:00

abstract：:Clinical effects of FOLFOX4 and TPF chemotherapy regimen on postoperative gastric cancer patients were investigated. A total of 60 patients admitted to the First People's Hospital of Changzhou receiving gastric cancer operation were selected and they were divided into two groups at random. Thirty patients in the FOLFO...

journal_title：Oncology letters

authors： Xie H,Lu Q,Wang H,Zhu X,Guan Z

更新日期：2019-01-01 00:00:00

abstract：:Nucleobindin 2 (NUCB-2) is a multifunctional protein that contains several functional domains and is associated with a wide variety of biological processes, such as food intake and energy homeostasis. NUCB-2 has been demonstrated to be associated with worse malignant outcomes and cell migration in breast and prostate ...

journal_title：Oncology letters

authors： Tao R,Niu WB,Dou PH,Ni SB,Yu YP,Cai LC,Wang XY,Li SY,Zhang C,Luo ZG

更新日期：2020-06-01 00:00:00