Abstract:
:Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae) is widely used in traditional Chinese medicine as an antifungal, antibacterial and anti-inflammatory agent. Plumbagin is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. The transcriptional co-factor four and a half LIM domains 2 (FHL2) is a multifunctional adaptor protein that is involved in the regulation of gene expression, signal transduction and cell proliferation and differentiation, and also acts as a tumor suppressor or oncoprotein depending on the tissue microenvironment. The present study investigated the effect of plumbagin on FHL2 expression, Wnt/β-catenin signalling and its anti-proliferative activity in various human osteosarcoma cell lines, including SaOS2, MG63, HOS and U2OS. The cells were exposed to plumbagin and the expression of FHL2 was evaluated using western blot analysis. Furthermore, the anti-proliferative effect of plumbagin was evaluated using a 3-(4,5 dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, since FHL2 is involved in Wnt/β-catenin signaling, the effect of plumbagin on β-catenin and its primary target genes, including v-myc avian myelocytomatosis viral oncogene homolog (c-Myc) and WNT1 inducible signaling pathway protein-1 (WISP-1), was evaluated using western blot analysis. It was observed that plumbagin suppressed the expression of FHL2 and exhibited significant anti-proliferative activity in osteosarcoma cells. It also attenuated Wnt/β-catenin signalling by downregulating β-catenin and its target genes, including c-Myc and WISP-1. In conclusion, plumbagin demonstrated anti-proliferative activity in osteosarcoma cells by downregulating FHL2 and interfering with Wnt/β-catenin signalling.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xue YL,Meng XQ,Ma LJ,Yuan Zdoi
10.3892/ol.2016.4725subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1095-1100issue
2eissn
1792-1074issn
1792-1082pii
OL-0-0-4725journal_volume
12pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.644
更新日期:2012-06-01 00:00:00
abstract::The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3720
更新日期:2015-11-01 00:00:00
abstract::Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3193
更新日期:2015-07-01 00:00:00
abstract::Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5410
更新日期:2017-01-01 00:00:00
abstract::Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6329
更新日期:2017-08-01 00:00:00
abstract::The use of 5α-reductase inhibitors (5α-RIs) as prostate cancer chemoprevention agents is controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial, have both shown a decreased incidence of prostate cancer in patient...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2388
更新日期:2014-10-01 00:00:00
abstract::The endogenous lipid metabolism network is associated with the occurrence and progression of malignancies. Endocannabinoids and ceramides have demonstrated their anti-proliferative and pro-apoptotic properties in a series of cancer studies. The aim of the present study was to evaluate the expression patterns of endoca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10399
更新日期:2019-08-01 00:00:00
abstract::The present study aimed to examine whether serum microRNA (miR)-22 may be considered a potential biomarker to differentiate patients with papillary thyroid cancer (PTC) from healthy controls. Reverse transcription-quantitative polymerase chain reaction demonstrated that serum miR-22 expression was significantly enhanc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10011
更新日期:2019-03-01 00:00:00
abstract::Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5572
更新日期:2017-03-01 00:00:00
abstract::The basic helix-loop-helix transcription factor AP4 (TFAP4) gene serves an important function in the genesis and progression of tumors. However, few studies to date have defined the role of this gene in colorectal cancer (CRC). The aim of the present study was to assess the expression of TFAP4 in CRC and its impact on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8290
更新日期:2018-05-01 00:00:00
abstract::Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9448
更新日期:2018-11-01 00:00:00
abstract::The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1744
更新日期:2014-02-01 00:00:00
abstract::The downregulation of farnesoid X receptor (FXR; gene name, nuclear receptor subfamily 1 group h member 4), an enteric nuclear bile acid receptor, has been reported in colorectal carcinoma (CRC), and FXR expression has been inversely correlated with CRC stage and clinical outcome. FXR knockdown in chronic colitis mous...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11545
更新日期:2020-07-01 00:00:00
abstract::Epigenetic regulatory mechanisms are a current focus in studies investigating cancer. Chromatin remodeling alters chromatin structure and regulates gene expression, and aberrant chromatin remodeling is involved in carcinogenesis. AT-rich interactive domain-containing protein 1A (ARID1A) and SWItch/sucrose non-fermenta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6891
更新日期:2017-11-01 00:00:00
abstract::Askin tumors are rare malignant neoplasms that are localized in the thoracopulmonary region and mainly occur in children and adolescents. Further investigation with regard to the effective treatment of this disease is required, since the disease has a low incidence and limited knowledge is available on the biological ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1488
更新日期:2013-10-01 00:00:00
abstract::The aim of the present study was to evaluate the utility of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis of common renal tumors. Conventional magnetic resonance imaging and DWI were performed on 85 patients with renal lesions (54 renal carcinoma and 31 renal angiomyolipoma cases). The apparent ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3605
更新日期:2015-10-01 00:00:00
abstract::Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves an important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression of RACK1 in gastric cancer (GC), and its association with the occurrence and development of GC. In ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6741
更新日期:2017-10-01 00:00:00
abstract::A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endotheli...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2104
更新日期:2014-07-01 00:00:00
abstract::Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10178
更新日期:2019-06-01 00:00:00
abstract::The aim of the present study was to identify genes that may serve as markers for breast cancer prognosis by constructing a gene co-expression network and mining modules associated with survival. Two gene expression datasets of breast cancer were downloaded from ArrayExpress and genes from these datasets with a coeffic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6779
更新日期:2017-10-01 00:00:00
abstract::Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8572
更新日期:2018-06-01 00:00:00
abstract::The aim of this study was to investigate the correlation between Girdin and PI3K in breast cancer stem cells and the clinical implications of the co-expression of these two proteins in breast cancer patients. CD44+/CD24- tumor cells from the MD-231 cell line were sorted by flow cytometry. The expression status of Gird...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1249
更新日期:2013-05-01 00:00:00
abstract::Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNA that have gained attention from researchers for their involvement in multiple biological processes. circRNAs are ubiquitously expressed in eukaryotic cells and regulate gene expression at the transcriptional or post-transcriptional level by interac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7118
更新日期:2017-12-01 00:00:00
abstract::No evidence currently exists to demonstrate the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with unresectable colorectal cancer liver metastases (CRLM). Therefore, we retrospectively investigated the correlation between serum CEA and CA19-9 levels and ove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.574
更新日期:2012-04-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2738
更新日期:2015-02-01 00:00:00
abstract::Exosomes derived from tumor cells are essential for processes involved in tumor progression, including angiogenesis, tumor cell proliferation and immunoregulation. In addition, exosome secretion may contribute to the mechanisms of hypoxia-induced angiogenesis and metastasis of tumors. In the present study, as it is on...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3841
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2017.6254.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,已发布勘误
doi:10.3892/ol.2017.6794
更新日期:2017-10-01 00:00:00
abstract::The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4541
更新日期:2016-06-01 00:00:00
abstract::The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5673
更新日期:2017-03-01 00:00:00