Abstract:
:Newcastle disease virus (NDV) has been reported to selectively duplicate in and then destroy tumor cells, whilst sparing normal cells. However, the effect of NDV on lung cancer has yet to be elucidated. In the present study, recombinant NDV (rl-RVG) was applied to lung adenocarcinoma A549 cell tumor-bearing mice to explore its effect on the proliferation of the cells and the immune response of the mice. Following rl-RVG transfection, RVG and NDV gene expression, decreased tumor growth, subcutaneous tumor necrosis, tumor apoptosis and an increased number of cluster of differentiation (CD)3-/CD49+ natural killer cells were more evident in the rl-RVG group. The present study demonstrated that rl-RVG transfection effectively restrained lung adenocarcinoma A549 cell growth in vivo, which may have been accomplish by inducing tumor cell apoptosis and regulating the cell immune response.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Yan Y,Jia L,Zhang J,Liu Y,Bu Xdoi
10.3892/ol.2014.2562subject
Has Abstractpub_date
2014-12-01 00:00:00pages
2569-2576issue
6eissn
1792-1074issn
1792-1082pii
ol-08-06-2569journal_volume
8pub_type
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