Abstract:
:MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell proliferation, migration and invasion. Additionally, upregulated miR-506 increased E-cadherin, and reduced N-cadherin and Vimentin expression levels, as markers of epithelial-to-mesenchymal transition. RWD domain containing 4 (RWDD4) was revealed to be a miR506 target in BCa cells, and the downregulation of RWDD4 was found to suppress BCa cell proliferation, migration and invasion. In summary, miR-506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Hou Ydoi
10.3892/ol.2018.9594subject
Has Abstractpub_date
2019-01-01 00:00:00pages
73-78issue
1eissn
1792-1074issn
1792-1082pii
OL-0-0-9594journal_volume
17pub_type
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