Abstract:
:We experienced a rare case of primary intracranial choriocarcinoma treated successfully with synchronous chemotherapy and radiotherapy followed by three consecutive courses of chemotherapy without surgery. A 19-year-old male patient presented with a two-week history of diplopia, headache, nausea and vomiting. Neurological examination revealed visual disturbance, bilateral hearing loss, bilateral sixth nerve palsy, left skew deviation, downgaze limitation and clockwise torsional nystagmus on the left upgaze. During image evaluation, the patient suddenly presented with a confused mental status, bradycardia and decreased respiration. An emergency third ventriculostomy was conducted, followed by synchronous ifosfamide, cisplatin and etoposide chemotherapy (ICE; I, 900 mg/m(2); C, 20 mg/m(2); and E, 60 mg/m(2)) on days 1-5, and external radiotherapy (whole brain, 30 Gy/15 Fxs; local boost, 30 Gy/15 Fxs) followed again by three consecutive courses of chemotherapy. This therapy resulted in tumor regression by 63% and full improvement in the patient's neurological condition. However, it was difficult to remove the remaining tumor using a surgical approach due to the risk of postoperative hemorrhage and limited access. We planned to observe the remaining mass without surgery. This patient is now alive and the mass size has not changed for 18 months since treatment. This is the first report of the effectiveness of synchronous chemotherapy and radiotherapy followed by consecutive chemotherapy without surgery in a patient with primary intracranial choriocarcinoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kim M,Yun J,Hur SM,Moon JJ,Nam JH,Kim SH,Kim HJ,Kim CK,Park SK,Hong DSdoi
10.3892/ol.2012.901subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1389-1391issue
6eissn
1792-1074issn
1792-1082pii
ol-04-06-1389journal_volume
4pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9677
更新日期:2019-01-01 00:00:00
abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.427
更新日期:2012-01-01 00:00:00
abstract::The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow-up. Due to the rapid growth of the lesion, further examinations were performed. Comput...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3718
更新日期:2015-11-01 00:00:00
abstract::Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human e...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3311
更新日期:2015-08-01 00:00:00
abstract::Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9111
更新日期:2018-09-01 00:00:00
abstract::The present study aimed to investigate the impact of overexpression of long noncoding RNA PEG10 (lncRNA PEG10) on the proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma (HSCC). Quantitative reverse transcription polymerase chain reaction was used to quantify lncRNA PEG10 expression levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6498
更新日期:2017-09-01 00:00:00
abstract::In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9616
更新日期:2019-01-01 00:00:00
abstract::Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative com...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6353
更新日期:2017-08-01 00:00:00
abstract::Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4605
更新日期:2016-07-01 00:00:00
abstract::Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3422
更新日期:2015-09-01 00:00:00
abstract::The aim of the present study was to investigate the expression of transactivation response RNA-binding protein (TARBP)1 and its clinical significance in human non-small-cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8202
更新日期:2018-05-01 00:00:00
abstract::Stromal cell-derived factor 1α (SDF1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric cancer (GC) cells through the CXCR4 axis in a h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12299
更新日期:2021-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8688
更新日期:2018-07-01 00:00:00
abstract::There is a growing body of evidence indicating that several melanoma-associated antigen-A (MAGE-A) subgroups contribute to the malignancy of head and neck cancer. The present study retrospectively analyzed the expression of all known MAGE-A subgroups in the tumor front and center of 38 head and neck cancer patients (U...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4945
更新日期:2016-10-01 00:00:00
abstract::Few studies on cervical intraepithelial neoplasia (CIN) keratinocyte cultures are available due to the numerous technical and methodological problems associated with the in vitro cultivation of these cells. The present study investigated an applicable and effective method for the in vitro cultivation of high-grade CIN...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4096
更新日期:2016-02-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00
abstract::In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1763
更新日期:2014-03-01 00:00:00
abstract::The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000034
更新日期:2010-01-01 00:00:00
abstract::Angioleiomyoma of the nasal cavity is extremely rare. There are only a small number of studies in the literature that demonstrate that the estrogen receptor (ER) and progesterone receptor (PR) are expressed in angioleiomyoma, and the results from these studies are inconsistent. The present study identified 6 patients ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4230
更新日期:2016-04-01 00:00:00
abstract::The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3248
更新日期:2015-07-01 00:00:00
abstract::Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6983
更新日期:2017-11-01 00:00:00
abstract::The aim of the present study is to investigate if rapamycin is a radiosensitizer of nasopharyngeal carcinoma (NPC), and to identify which pathways are involved in radiation sensitization. In vitro, using untreated cells as the control, NPC cells were treated with rapamycin, ionizing radiation (IR) or both. Differences...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6208
更新日期:2017-07-01 00:00:00
abstract::Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5415
更新日期:2017-01-01 00:00:00
abstract::Previous studies have demonstrated that the chronic administration of valproic acid (VPA) suppresses angiogenesis in vivo; however, the mechanisms implicated in VPA-induced autophagy remain unclear. The current study aimed to assess VPA-induced autophagy in three prostate cancer cell lines (PC3, DU145 and LNCaP), in a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4880
更新日期:2016-09-01 00:00:00
abstract::The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannomas (VS) measuring 5.25 and 2.54 cm3 on the left and right, respectively. His cap...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4347
更新日期:2016-05-01 00:00:00
abstract::Docetaxel is a well-known causative agent of nail alterations. The aim of this study was to reveal the impact of nail alterations associated with low-dose metronomic (LDM) docetaxel chemotherapy on the survival of non-small cell lung cancer (NSCLC) patients. Clinical information, survival data and nail alterations in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1178
更新日期:2013-04-01 00:00:00
abstract::Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10178
更新日期:2019-06-01 00:00:00
abstract::MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8443
更新日期:2018-06-01 00:00:00
abstract::The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1676
更新日期:2014-01-01 00:00:00
abstract::Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNA that have gained attention from researchers for their involvement in multiple biological processes. circRNAs are ubiquitously expressed in eukaryotic cells and regulate gene expression at the transcriptional or post-transcriptional level by interac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7118
更新日期:2017-12-01 00:00:00